PARP

作品数：278被引量：845H指数：13
导出分析报告
相关领域：医药卫生更多>>
相关作者：王娅兰陈德风蔡莉陈雅文郝兰香更多>>
相关机构：重庆医科大学吉林大学武汉大学中国医科大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金重庆市自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
血管生成抑制剂和PARP抑制剂治疗复发性卵巢癌有效性评价的网状meta分析
《中国医师杂志》2025年第1期11-17,共7页苏秋源 谭佳佳 赵玲 况燕 
国家自然科学基金(82260566,81960466)。
目的运用网状meta系统,分析血管生成抑制剂和聚ADP核糖聚合酶(PARP)抑制剂在治疗复发性卵巢癌中的有效性。方法采用主题词检索Pubmed、Embase、the Cochrane Library和web of science数据库,收集血管生成抑制剂和PARP抑制剂治疗复发性...
关键词：血管生成抑制剂 聚ADP核糖聚合酶抑制剂 卵巢肿瘤 肿瘤复发 
靶向铁死亡调控卵巢癌细胞对PARP抑制剂敏感性的机制研究
《湖南师范大学学报(医学版)》2024年第6期5-10,共6页蔡立 杨银河 张秀 李贝 刘晓亭 吴娜怡园 
湖南省自然科学基金“CSF-1R抑制剂促进铁死亡增强卵巢癌PARP抑制剂敏感性的作用与分子机制”(2023JJ60016)
目的:多聚腺苷二磷酸核糖聚合酶抑制剂(poly ADP-ribose polymerase inhibitors,PARP inhibitors)已成为卵巢癌维持治疗的重要手段,可显著延长患者生存期。然而,随着治疗的深入,部分患者逐渐表现出对PARP抑制剂的耐药性,这限制了其临床...
关键词：卵巢癌 PARP抑制剂 铁死亡 CSF-1R SLCO2B1 
Synergistic effect of poly(ADP-ribose)polymerase(PARP)inhibitor with chemotherapy on CXorf67-elevated posterior fossa group A ependymoma
《Chinese Medical Journal》2024年第22期2770-2772,共3页Jichang Han Jianzhong Yu Meng Yu Yachao Liu Xiaomin Song Hao Li Lin Li 
supported by grants from the National Natural Science Foundation of China(Nos.92253303,92053201,and 82103123);the National Key Research and Development Program of China(No.2019YFA0802002);the China Postdoctoral Science Foundation(No.2021M703208).
To the Editor:Posterior fossa group A(PFA)ependymoma is one of the most common and aggressive pediatric tumors,which currently lacks effective chemotherapies.[1,2]Previously,we revealed CXorf67,which is specially unre...
关键词：drugs ELEVATED RENDER 
PARP7 and nucleic acid-driven oncosuppression
《Cellular & Molecular Immunology》2024年第11期1177-1179,共3页Flavie Naulin Emma Guilbaud Lorenzo Galluzzi 
supported(as a PI,unless otherwise indicated)by one NIH R01 grant(#CA271915);by two Breakthrough Level 2 grants from the US DoD BCRP(#BC180476P1,#BC210945);by a grant from the STARR Cancer Consortium(#I16-0064);by a Transformative Breast Cancer Consortium Grant from the US DoD BCRP(#W81XWH2120034,PI:Formenti);by a U54 grant from NIH/NCI(#CA274291,PIs:Deasy,Formenti,Weichselbaum);by the 2019 Laura Ziskin Prize in Translational Research(#ZP-6177,PI:Formenti)from the Stand Up to Cancer(SU2C)Foundation;by a Mantle Cell Lymphoma Research Initiative(MCL-RI,PI:Chen-Kiang)grant from the Leukemia and Lymphoma Society(LLS);by a Rapid Response Grant from the Functional Genomics Initiative(New York,US);by a pre-SPORE grant(PIs:Demaria,Formenti);a Collaborative Research Initiative Grant and a Clinical Trials Innovation Grant from the Sandra and Edward Meyer Cancer Center(New York,US);by startup funds from the Dept.of Radiation Oncology at Weill Cornell Medicine(New York,US);by industrial collaborations with Lytix Biopharma(Oslo,Norway),Promontory(New York,US)and Onxeo(Paris,France);by donations from Promontory(New York,US);the Luke Heller TECPR2 Foundation(Boston,US),Sotio a.s.(Prague,Czech Republic);Lytix Biopharma(Oslo,Norway);Onxeo(Paris,France);Ricerchiamo(Brescia,Italy);Noxopharm(Chatswood,Australia).
TCDD-inducible poly(ADP-ribose)polymerase(TIPARP,best known as PARP7)has previously been shown to promote oncogenesis by limiting the cytosolic accumulation of potentially interferogenic nucleic acids in malignant cel...
关键词：INDUCIBLE PARP MONO 
PARP抑制剂治疗转移性去势抵抗性前列腺癌有效性及安全性的Meta分析
《海南医学院学报》2024年第20期1570-1578,共9页刘琳 盛佳丽 卢彦达 郑少江 
海南省临床医学研究中心资助项目(QWYH2022341);海南省院士团队创新中心项目(YSPTZX202208)。
目的:系统评价PARPi治疗转移性去势抵抗性前列腺癌(mCRPC)的有效性及安全性,以期为临床决策供循证医学证据。方法:依据纳入和排除标准,网络检索2015年1月~2023年6月PubMed、Web of Science、Embace、Clinicial.gov中有关PARPi治疗mCRPC...
关键词：多聚腺苷二磷酸核糖聚合酶抑制剂 转移性去势抵抗性前列腺癌 有效性 安全性 META分析 
HPLC法检查奥拉帕利原料中有关物质被引量：1
《药物分析杂志》2024年第8期1379-1386,共8页邹艳 吴海龙 邓丽 胡川 李宏名 
目的:建立高效液相色谱法检测奥拉帕利原料中的有关物质。方法:采用YMC-Pack pro C_(18)AS(150 mm×4.6 mm,3μm)色谱柱,以0.05 mol·L^(-1)的磷酸二氢钾(用稀磷酸调pH至3.0)-甲醇-乙腈(90∶5∶5)为流动相A,甲醇-乙腈-水(45∶45∶10)为...
关键词：奥拉帕利 聚腺苷二磷酸核糖聚合酶(PARP)抑制剂 有关物质 方法研究 质量控制 高效液相色谱 
Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts
《Signal Transduction and Targeted Therapy》2024年第8期3163-3164,共2页Marina Kolesnichenko Claus Scheidereit 
This work was supported in part by DFG grant KO6390/1-1,C3R,and Fritz Thyssen Foundation 80003214-01 to M.K.;by general support of Max Delbruck Center for Molecular Medicine in the Helmholtz Association(MDC)to C.S.
In a landmark study recently published in Nature,Petropoulous et al.demonstrated that synthetic lethality of poly(ADP-ribose)polymerase(PARP)inhibitors in cells with defective homologous recombination repair(HR)result...
关键词：PARP MECHANISM 
PARP抑制剂治疗卵巢癌的耐药机制及应对策略
《中华临床医师杂志(电子版)》2024年第6期584-588,共5页徐靖亭 孔璐 
首都医科大学长学制导师科研训练项目(CXZDS2022038)
卵巢癌致死率居妇科肿瘤之首,DNA损伤修复缺陷是卵巢癌发生的重要原因之一。乳腺癌易感基因(BRCA)1和2缺失突变的频发,导致卵巢癌中同源重组修复(HRR)机制障碍。近年研究指出,作为DNA损伤修复的关键酶,多聚ADP-核糖聚合酶1(PARP1)的基因...
关键词：卵巢癌 多聚ADP-核糖聚合酶1 多聚ADP-核糖聚合酶抑制剂 耐药机制 
HDAC-driven mechanisms in anticancer resistance:epigenetics and beyond
《Cancer Drug Resistance》2024年第1期166-188,共23页Martina Minisini Martina Mascaro Claudio Brancolini 
Research work in the CB lab is supported by AIRC under IG 2021-ID.26200 project;Interreg Italia Osterreich ITAT11-018 SENECA,CIB“Modelli innovativi per applicazioni di scienze omiche avanzate-Tecnologie innovative per le scienze omiche avanzate in modelli umani e vegetali”.
The emergence of drug resistance leading to cancer recurrence is one of the challenges in the treatment of cancer patients.Several mechanisms can lead to drug resistance,including epigenetic changes.Histone deacetylas...
关键词：HDACS chemotherapy hormone deprivation ACETYLATION palbociclib PARP DNA damage 
Mechanism of PARP inhibitor resistance and potential overcoming strategies
《Genes & Diseases》2024年第1期306-320,共15页Xiaoyu Fu Ping Li Qi Zhou Ruyuan He Guannan Wang Shiya Zhu Amir Bagheri Gary Kupfer Huadong Pei Juanjuan Li 
PARP inhibitors(PARPi)are a kind of cancer therapy that targets poly(ADP-ribose)polymerase.PARPi is the first clinically approved drug to exert synthetic lethality by obstruct-ing the DNA single-strand break repair pr...
关键词：Drug resistance Homologous recombination PARP PARP inhibitor Poly(ADP-ribose)polymerase 
全选清除导出
共28页<12345678910>
检索报告 对象比较 聚类工具 使用帮助 返回顶部