Synergistic effect of poly(ADP-ribose)polymerase(PARP)inhibitor with chemotherapy on CXorf67-elevated posterior fossa group A ependymoma  

作　　者：Jichang Han Jianzhong Yu Meng Yu Yachao Liu Xiaomin Song Hao Li Lin Li 

机构地区：[1]State Key Laboratory of Molecular Biology,CAS Center for Excellence in Molecular Cell Science,Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China [2]Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,Zhejiang 310024,China [3]Department of Neurosurgery,Children’s Hospital of Fudan University,Shanghai 201102,China [4]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《Chinese Medical Journal》2024年第22期2770-2772,共3页中华医学杂志(英文版)

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.92253303,92053201,and 82103123);the National Key Research and Development Program of China(No.2019YFA0802002);the China Postdoctoral Science Foundation(No.2021M703208).

摘　　要：To the Editor:Posterior fossa group A(PFA)ependymoma is one of the most common and aggressive pediatric tumors,which currently lacks effective chemotherapies.[1,2]Previously,we revealed CXorf67,which is specially unregulated in PFA ependymoma,as a negative regulator of DNA homologous recombination(HR)repair,rendered PFA tumors highly sensitive to poly(ADP-ribose)polymerase(PARP)inhibitors combined with radiotherapy through a mechanism of synthetic lethality.[3]However,PFA ependymoma mostly occurs in infants and young children,to whom ionizing radiation may pose great risks.Therefore,there is still an urgent need in the treatment of PFA ependymoma patients who could not or are reluctant to receive radiotherapy.Given that platinum-based drugs(cisplatin and carboplatin),as DNA damaging agents,are widely used as anticancer drugs.This study aimed to investigate whether the combination of PARP inhibitors and DNA-damaging chemotherapy could efficiently kill CXorf67-expressing tumor cells.

关 键 词：drugs ELEVATED RENDER 

分 类 号：R73[医药卫生—肿瘤]