DIINDOLYLMETHANE

作品数：9被引量：8H指数：2
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相关领域：医药卫生更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Journal of Chinese Pharmaceutical Sciences》《Chinese Journal of Chemistry》更多>>
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Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway
《Acta Pharmacologica Sinica》2023年第6期1262-1276,共15页Qi-qi Song Li-ping Lin Ya-li Chen Jia-cheng Qian Ke Wei Jian-wei Su Jian-hua Ding Ming Lu Yang Liu Ren-xiang Tan Gang Hu 
supported by grants from the National Key R&D Program of China(Nos.2021ZD0202901,2018YFC1706205);the National Natural Science Foundation of China(Nos.81991523,82073721).
Malignant glioma is the most fatal,invasive brain cancer with limited treatment options.Our previous studies show that 2-(indol-3-ylmethyl)-3,3′-diindolylmethane(LTr1),a major metabolite of indole-3-carbinol(I3C)deri...
关键词：malignant glioma 2-(indol-3-ylmethyl)-33′-diindolylmethane(LTr1) TRKA reactive oxygen species S phase cell cycle arrest mitochondrial pathway PACLITAXEL cruciferous vegetables 
Antibiofilm activity of 3,3'-diindolylmethane on Staphylococcus aureus and its disinfection on common food-contact surfaces
《Food Science and Human Wellness》2022年第5期1222-1232,共11页Hui Zhang Xiaomei Guo Lei Tian Na Wang Yuqing Li Ariel Kushmaro Robert Marks Qun Sun 
supported by the National Key Research and Development Projects(2019YFE0103800);Sichuan Science and Technology Program(2019YFH0113,2021YFH0060,2021YFH0072,2021ZHFP0045,2021YFN0092);the Fundamental Research Funds for the Central Universities(2018CDLZ-07,2018CDPZH-9,2019CDPZH-23,2020CDLZ-17)。
This study explored the antibiofilm efficacy of 3,3’-diindolylmethane(DIM)on Staphylococcus aureus and its disinfection on common food-contact surfaces.The minimum biofilm inhibitory concentration(MBIC)of DIM on S.au...
关键词：Biofilm inhibition 3 3’-Diindolylmethane Extracellular DNA Extracellular polysaccharide Food-contact surfaces 
Post-ingestion conversion of dietary indoles into anticancer agents
《National Science Review》2022年第4期123-133,共11页Li Ping Lin Dan Liu Jia Cheng Qian Liang Wu Quan Zhao Ren Xiang Tan 
supported by the National Natural Science Foundation of China (81991524 and 82073721);the National Key Research and Development Program of China(2018YFC1706200);the Jiangsu Provincial Natural Science Foundation (BK20180159)。
There are health benefits from consuming cruciferous vegetables that release indole-3-carbinol(I3 C), but the in vivo transformation of I3 C-related indoles remains underinvestigated. Here we detail the post-ingestion...
关键词：INDOLE-3-CARBINOL reaction flux derailing(RFD)approach 2-(indol-3-ylmethyl)-3 3′-diindolylmethane(LTr1) ANTICANCER Lactobacillus acidophilus 
Development and validation of a rapid UPLC/MS method for the simultaneous determination of I3C, DIM, and related metabolites and its application to pharmacokinetics studies
《Journal of Chinese Pharmaceutical Sciences》2016年第7期477-488,共12页Yury Gomez Hu Wang Ah-Ng Tony Kong 
R01 CA118947;R01 CA152826 from National Cancer Institute(NCI);R01AT007065 from the National Center for Complementary and Alternative Medicines(NCCAM);the Office of Dietary Supplements(ODS);the National Institute of Health Grant R01 CA073674
Indole-3-carbinol(I3C) and diindolylmethane(DIM) are naturally derived dietary phytochemicals with promising anti-cancer properties that have been demonstrated both in vitro and in vivo. Using reversed-phase ultra-per...
关键词：UPLC/MS INDOLE-3-CARBINOL DIINDOLYLMETHANE PHARMACOKINETICS SINGLE-DOSE administration SPRAGUE-DAWLEY Rats 
Modulation of signal transduction pathways by natural compounds in cancer被引量：2
《Chinese Journal of Natural Medicines》2015年第10期730-742,共13页Alok Ranjan Neel M.Fofaria Sung-Hoon Kim Sanjay K.Srivastava 
supported in part by NIH/National Cancer Institute R01 grant CA129038(to S.K.S);MEST grant 2012–0005755(to S.H.K)
Cancer is generally regarded as the result of abnormal growth of cells. According to World Health Organization, cancer is the leading cause of mortality worldwide. Mother nature provides a large source of bioactive co...
关键词：Natural compounds CAPSAICIN Curcumin Diindolylmethane(DIM) ISOTHIOCYANATE PIPERINE DEGUELIN Cucurbitacin B CANCER 
Multiple therapeutic and preventive effects of 3,3'-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia被引量：1
《The Journal of Biomedical Research》2014年第5期339-348,共10页William Weiben Zhang Zhenqing Feng Steven A Narad 
Cruciferous vegetables belong to the plant family that has flowers with four equal-sized petals in the pattern of a crucifer cross.These vegetables are an abundant source of dietary phytochemicals,including glucosinol...
关键词：cruciferous vegetables 3 3＇-diindolylmethane（DIM） indole-3-carbinol（I3C） prostate cancer high grade prostatic intraepithelial neoplasia（HGPIN） 
Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals
《Acta Pharmacologica Sinica》2007年第9期1274-1304,共31页Lynne M HOWELLS Elena P MOISEEVA Christopher PNEAL Bethany EFOREMAN Catherine KANDREADI Yi-yang SUN E Ann HUDSON Margaret M MANSON 
The corresponding author's laboratory is supported by the UK Medical Research Council and the EU Network of Excellence,ECNIS.
There is growing interest in the ability of phytochemicals to prevent chronic diseases, such as cancer and heart disease. However, some of these agents have poor bioavailability and many of the in-depth studies into t...
关键词：bioavailability cancer chemoprevention curcumin diet DIINDOLYLMETHANE epigallocatechin-3-gallate INDOLE-3-CARBINOL RESVERATROL 
Anticarcinogenic and antioxidant activity of diindolylmethane derivatives被引量：4
《Acta Pharmacologica Sinica》2004年第5期666-671,共6页SakinaHayatBENABADJI RenWEN Jian-binZHENG Xiao-chunDONG Shen-gangYUAN 
Project supported by the National Natural Science Foundationof China (No 29872029) and International Cooperation (No20010140417).
AIM: To investigate the synthesis methods and the bioactivity of diindolylmethane (DIM) derivatives. METHODS:1) A 3D-Quantitative Structure-Active Relationships (QSAR) Comparative Molecular Field Analysis (CoMFA) stu...
关键词：INDOLE-3-CARBINOL DIINDOLYLMETHANE CoMFA analysis ANTIOXIDANTS free radical scavengers 1 1-DPPH carotenoids antitumor drug screening assay 
3D-QSAR Study on Diindolylmethane and Its Analogues with Comparative Molecular Field Analysis (CoMFA)被引量：1
《Chinese Journal of Chemistry》2003年第1期20-24,共5页BENABADJI Sakin Hayat 陈海峰 袁身刚 闻韧 
ProjectsupportedbytheMajorStateBasicResearchDevelopmentProgram (No .G19980 5 1115 )andtheNationalNaturalScienceFoundationofChina (Nos .2 9832 0 5 0 ,2 9872 0 48,2 9872 0 2 9and 2 0 0 730 5 8)
Comparative molecular field analysis (CoMFA), a three dimensional quantitative structure-activity relationship (3D-QSAR) method was applied to a series of diindolylmethane (DIM) analogs to study the relationship betwe...
关键词：D-QSAR COMFA DIINDOLYLMETHANE CYP 1A1 
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