中药干预乳腺癌氧化磷酸化的研究进展  

Research Progress in the Effect of Chinese Medicine on Oxidative Phosphorylation of Breast Cancer

作　　者：唐苏媛 孙有智[1] 刘振豪 赵益[3] TANG Suyuan;SUN Youzhi;LIU Zhenhao;ZHAO Yi(Formula-Syndrome Research Center,Jiangxi University of Chinese Medicine,Nanchang 330004;School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004;Research Center of Differentiation and Development of TCM Basic Theory,Jiangxi University of Chinese Medicine,Nanchang 330004)

机构地区：[1]江西中医药大学方-证研究中心,南昌330004 [2]江西中医药大学药学院,南昌330004 [3]江西中医药大学中医基础理论分化发展研究中心,江西330004

出　　处：《中药药理与临床》2024年第5期115-122,共8页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金项目(编号:82060868);江西省自然科学基金项目(编号:20202BABL206127);江西省教育厅科技项目(编号:GJJ2200907);江西省中医药骨干人才培养项目(赣中医药科教字[2021]4号);江西中医药大学校级科技创新团队发展计划(编号:CXTD22007);熊墨年国医名师传承工作室建设项目(赣中医药综合字[2021]12号)。

摘　　要：氧化磷酸化(OXPHOS)对肿瘤细胞的能量代谢起着重要的调节作用,近年来中药对其干预作用的研究越来越多。为更好地梳理中药对肿瘤细胞氧化磷酸化的影响,本文就近年来中药对乳腺癌氧化磷酸化代谢方式的干预研究进行综述。发现有19个中药成分可影响乳腺癌细胞的OXPHOS,涉及清热解毒、疏肝理气、活血化瘀、清热化湿等中药,其作用机理与调控线粒体复合物Ⅰ、Ⅱ活力,增加细胞内活性氧水平,调节AKT/mTOR、ERK/AKT、SIRT6/NF-κB等信号通路,从而影响线粒体功能有关。这些研究为未来中医药在该领域的研究提供了有益的探索,具有重要的参考价值。Oxidative phosphorylation(OXPHOS)plays an important regulatory role in the energy metabolism of tumor cells,and in recent years,there have been an increasing number of studies of the intervention effect of Chinese medicine on OXPHOS.In order to summarize the effect of Chinese medicine on OXPHOS of tumor cells,this article reviewed the recent studies of the intervention of Chinese medicine in metabolic patterns of OXPHOS in breast cancer.The results showed that there were 19 Chinese medicine components affecting OXPHOS of breast cancer cells,involving Qingre(清热)and Jiedu(解毒)drugs,Shugan(疏肝)and Liqi(理气)drugs,Huoxue(活血)and Huayu(化瘀)drugs,and Qingre and Huashi(化湿)drugs.The underlying mechanism was attributed to the influence on mitochondrial function by regulating the activity of mitochondrial complexes I and II,increasing the level of reactive oxygen species in cells,regulating signaling pathways such as AKT/mTOR,ERK/Akt,and SIRT6/NF-κB.These studies can support the exploration of future research in this field of traditional Chinese medicine with an important reference value.

关 键 词：乳腺癌 氧化磷酸化 OXPHOS 中药 

分 类 号：R273[医药卫生—中西医结合]