BaTiO_(3)@Au nanoheterostructure suppresses triple-negative breast cancer by persistently disrupting mitochondrial energy metabolism  

作　　者：Yanlin Feng Jianlin Wang Xin Ning Aiyun Li Qing You Wanzhen Su Deping Wang Jianyun Shi Lan Zhou Fangfang Cao Xiaoyuan Chen Jimin Cao 

机构地区：[1]Key Laboratory of Cellular Physiology at Shanxi Medical University,Ministry of Education,and the Department of Physiology,Shanxi Medical University,Taiyuan 030001,China [2]Departments of Diagnostic Radiology,Surgery,Chemical and Biomolecular Engineering,and Biomedical Engineering,Yong Loo Lin School of Medicine and Faculty of Engineering,National University of Singapore,Singapore 119074,Singapore [3]Clinical Imaging Research Centre,Centre for Translational Medicine,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 117599,Singapore [4]Nanomedicine Translational Research Program,NUS Center for Nanomedicine,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 117597,Singapore

出　　处：《Nano Research》2023年第2期2775-2785,共11页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22007063 and 82002063);Shanxi Medical Key Science and Technology Project Plan of China(No.2020XM01);the National University of Singapore Start-up Grant(No.NUHSRO/2020/133/Startup/08);NUS School of Medicine Nanomedicine Translational Research Program(No.NUHSRO/2021/034/TRP/09/Nanomedicine);the Science Research Start-up Fund for Doctor of Shanxi Province(No.XD1809 and XD2011);the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2019L0414);Shanxi Province Science Foundation for Youths(No.201901D211316).

摘　　要：Abnormal metabolism has become a potential target for highly malignant and invasive triple-negative breast cancer(TNBC)due to its relatively low response to traditional therapeutics.The existing metabolic interventions demonstrated unsatisfactory therapeutic outcomes and potential systemic toxicity,resulting from the metabolic instability and limited targeting ability of inhibitors as well as complex tumor microenvironment.To address these limitations,here we developed a robust pyroelectric BaTiO_(3)@Au core–shell nanostructure(BTO@Au)to selectively and persistently block energy generation of tumor cells.Stimulated by near-infrared(NIR)laser,the Au shell could generate heat to activate the BaTiO_(3)core to produce reactive oxygen species(ROS)regardless of the constrained microenvironment,thus prominently inhibits mitochondrial oxidative phosphorylation(OXPHOS)and reduces ATP production to induce TNBC cell apoptosis.The therapeutic effects have been well demonstrated in vitro and in vivo,paving a new way for the development of metabolic interventions.

关 键 词：pyroelectric nanoheterostructure reactive oxidative species(ROS) metabolic interventions mitochondrial oxidative phosphorylation(OXPHOS) triple-negative breast cancer(TNBC) 

分 类 号：R730[医药卫生—肿瘤] TB383[医药卫生—临床医学]