Digesting gluten with oral endopeptidases to improve the management of celiac disease  

作　　者：Katelin Durham Mirac Nedim Ince 

机构地区：[1]Department of Internal Medicine,Division of Gastroenterology and Hepatology,University of Iowa,Carver College of Medicine,and the Iowa City Veterans Affairs Medical Center,Iowa City,IA 52242,United States

出　　处：《World Journal of Gastroenterology》2024年第26期3201-3205,共5页世界胃肠病学杂志（英文版）

基　　金：Supported by the VA Merit Award,2I01BX002906-05.

摘　　要：In our editorial,we want to comment on the article by Stefanolo et al titled“Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet”.Celiac disease is an immune-mediated disorder triggered by dietary gluten in genetically predisposed individuals.Although avoiding gluten can permit patients to live symptom-free,ongoing voluntary or involuntary exposure to gluten is common and associated with persistent villous atrophy in small bowel mucosa.As villous atrophy predisposes patients to life threatening complications,such as osteoporotic fractures or malignancies,therapeutic adjuncts to gluten-free diet become important to improve patients’quality of life and,if these adjuncts can be shown to improve villous atrophy,avoid complications.Oral administration of enzyme preparations,such as endopeptidases that digest gluten and mitigate its antigenicity to trigger inflam-mation,is one clinical strategy under investigation.The article is about the utility of one endopeptidase isolated from Aspergillus niger.We critique findings of this clinical trial and also summarize endopeptidase-based as well as other strategies and how they can complement gluten-free diet in the management of celiac disease.

关 键 词：Celiac disease Gluten-free diet ENDOPEPTIDASE Villous atrophy Aspergillus niger Adjunct therapy 

分 类 号：R57[医药卫生—消化系统]