C/EBPβ/AEP Signaling Drives Alzheimer's Disease Pathogenesis  

作　　者：Jing Xiong Zhentao Zhang Keqiang Ye 

机构地区：[1]Department of Neurology,Renmin Hospital of Wuhan University,Wuhan 430060,China [2]Faculty of Life and Health Sciences,Shenzhen Institute of Advanced Technology(SIAT),Shenzhen 518034,China

出　　处：《Neuroscience Bulletin》2023年第7期1173-1185,共13页神经科学通报（英文版）

基　　金：supported by start-up funding from Shenzhen Institute of Advanced Technology;the National Natural Science Foundation of China(No.82271446).

摘　　要：Alzheimer’s disease(AD)is the most common type of dementia.Almost two-thirds of patients with AD are female.The reason for the higher susceptibility to AD onset in women is unclear.However,hormone changes during the menopausal transition are known to be associated with AD.Most recently,we reported that follicle-stimulating hormone(FSH)promotes AD pathology and enhances cognitive dysfunctions via activating the CCAAT-enhancer-binding protein(C/EBPβ)/asparagine endopeptidase(AEP)pathway.This review summarizes our current understanding of the crucial role of the C/EBPβ/AEP pathway in driving AD pathogenesis by cleaving multiple critical AD players,including APP and Tau,explaining the roles and the mechanisms of FSH in increasing the susceptibility to AD in postmenopausal females.The FSH-C/EBPβ/AEP pathway may serve as a novel therapeutic target for the treatment of AD.

关 键 词：Alzheimer's disease C/EBPΒ Asparagine endopeptidase PATHOGENESIS Follicle stimulating hormone 

分 类 号：R749.16[医药卫生—神经病学与精神病学]