High-frequency terahertz waves disrupt Alzheimer’s β-amyloid fibril formation  

作　　者：Wenyu Peng Zhi Zhu Jing Lou Kun Chen Yuanming Wu Chao Chang 

机构地区：[1]Department of Biochemistry and Molecular Biology,Shaanxi Provincial Key Laboratory of Clinic Genetics,School of Basic Medicine,Air Force Medical University,Xi’an 710032,China [2]Innovation Laboratory of Terahertz Biophysics,National Innovation Institute of Defense Technology,Beijing 100071,China [3]Key Laboratory of Optical Technology and Instrument for Medicine,Ministry of Education,College of Optical-Electrical and Computer Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China [4]Department of Anatomy,Histology and Embryology and K.K.Leung Brain Research Centre,School of Basic Medicine,Air Force Medical University,Xi’an 710032,China [5]School of Physics,Peking University,Beijing 100871,China

出　　处：《eLight》2023年第1期85-93,共9页e光学（英文）

基　　金：supported by Innovation Laboratory of Terahertz Biophysics;financially supported by the National Natural Science Foundation of China(Grants No.12225511,T2241002);the key innovative project in Shaanxi(No.2021ZDLSF02-02,2022KXJ-123);sponsored by Shanghai Rising-Star Program(No.23QA1404200).

摘　　要：The accumulation and deposition of amyloid can cause a variety of neurodegenerative diseases,including Alzheimer’s and Parkinson’s disease.The degradation or clearance of this accumulation is currently the most widely accepted therapeutic strategy for intervention in these pathologies.Our study on amyloid-β(Aβ)oligomers in vitro revealed that high-frequency terahertz(THz)waves at a specific frequency of 34.88 THz could serve as a physical,efficient,non-thermal denaturation technique to delay the fibrotic process by 80%,as monitored by a thioflavine T(ThT)binding assay and Fourier transform infrared(FTIR)spectroscopy.Additionally,THz waves of this frequency have been shown to have no side effects on normal cells,as confirmed by cell viability and mitochondrial membrane potential assays.Furthermore,molecular dynamic(MD)simulations revealed that the THz waves could resonate with Aβ fibrils,disrupting the dense conformation by breaking the β-sheet structure and promoting the formation of abundant coil and bend structures.This study uses the amyloid of Aβ as an example,and the results will further guide interventions for the accumulation of other amyloids,which may provide new ideas for the remission of related diseases.

关 键 词：AMYLOID ALZHEIMER AΒ 

分 类 号：R749.16[医药卫生—神经病学与精神病学]