EXCITOTOXICITY

作品数：71被引量：272H指数：7
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相关领域：医药卫生更多>>
相关作者：于洋杨柳马春蕾孙晖王天佑更多>>
相关机构：滨州医学院北京市神经外科科研究所山东大学华东师范大学更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Frontiers in Biology》《Acta Pharmacologica Sinica》《International Journal of Ophthalmology(English edition)》更多>>
相关基金：国家自然科学基金国家教育部博士点基金国家重点基础研究发展计划湖北省自然科学基金更多>>
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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease
《Neural Regeneration Research》2025年第7期1981-1988,共8页Shan Ping Yu Emily Choi Michael QJiang Ling Wei 
supported by National Health Institute(NIH)grant NS099596(to LW and SPY),NS114221(to LW and SPY);Veterans Affair(VA)SPiRE grant RX003865(to SPY);supported by the O.Wayne Rollins Endowment Fund(to SPY);John E.Steinhaus Endowment Fund(to LW)。
Stroke and Alzheimer's disease are common neurological disorders and often occur in the same individuals.The comorbidity of the two neurological disorders represents a grave health threat to older populations.This rev...
关键词：Ca^(2+)hypothesis cognitive deficits HYPERACTIVITY late-onset Alzheimer's disease NEURODEGENERATION N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment 
Rodent ischemic stroke models and their relevance in preclinical research
《Neuroprotection》2024年第4期296-309,共14页Maria Thaysen Emil Westi Andrew N.Clarkson Petrine Wellendorph Mie Kristensen 
funded by the Independent Research Fund Denmark supporting work by Mie Kristensen and Maria Thaysen(grant no.2101-00013B);the Lundbeck Foundation,Neuroscience Academy Denmark supporting work by Petrine Wellendorph and Emil Westi(grant no.R389-2021-1596).
Stroke is a leading cause of death and disability worldwide,with ischemic stroke caused by an occluded vessel accounting for the majority of cases.Current treatments are limited to recanalization,either through thromb...
关键词：animal models endothelin-1 induced stroke EXCITOTOXICITY ischemic stroke middle cerebral artery occlusion photothrombotic stroke thromboembolic stroke 
Ruxolitinib improves the inflammatory microenvironment,restores glutamate homeostasis,and promotes functional recovery after spinal cord injury被引量：1
《Neural Regeneration Research》2024年第11期2499-2512,共14页Jiang Cao Xiao Yu Jingcheng Liu Jiaju Fu Binyu Wang Chaoqin Wu Sheng Zhang Hongtao Chen Zi Wang Yinyang Xu Tao Sui Jie Chang Xiaojian Cao 
supported by the National Natural Science Foundation of China,No.82272484(to XC).
The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord injury.Ruxolitinib,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arth...
关键词：astrocytes EAAT2 EXCITOTOXICITY glutamate homeostasis JAK-STAT pathway locomotor function NEUROTOXICITY RUXOLITINIB spinal cord injury transcriptome analysis 
p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model被引量：2
《Neural Regeneration Research》2024年第10期2299-2309,共11页Lemeng Feng Chao Wang Cheng Zhang Wulong Zhang Weiming Zhu Ye He Zhaohua Xia Weitao Song 
supported by the National Natural Science Foundation of China,Nos.81974132,81770927;Hunan Provincial Health Commission,No.20220702839;the Natural Science Foundation of Hunan Province of China,No.2022JJ30076;National Key R&D Program of China,No.2021YFA1101202(all to WS)。
Glutamate excitotoxicity has been shown to play an important role in glaucoma, and glutamate can induce ferroptosis. The p38 mitogenactivated protein kinase(MAPK) pathway inhibitor SB202190 has a potential ability to ...
关键词：ferroptosis GLAUCOMA glutamate excitotoxicity p38 MAPK retinal ganglion cell SB202190 
On implications of somatostatin in diabetic retinopathy
《Neural Regeneration Research》2024年第9期1984-1990,共7页Yanhong Fang Qionghua Wang Youjian Li Li Zeng Jian Liu Kepeng Ou 
supported by the Natural Science Foundation of Chongqing of China,Nos.cstc2020jcyj-msxmX0698(to YF),cstc2021jcyjbshX0147(to KO);a grant from Chongqing Jiangjin District Bureau of Science and Technology,No.Y2022017(to YF).
Somatostatin,a naturally produced neuroprotective peptide,depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina.In this review,we summarize the progress of so...
关键词：diabetes retinopathy EXCITOTOXICITY growth hormone insulin like growth factor irisin NEURODEGENERATION NEUROINFLAMMATION neuroprotection neurovascular unit OCTREOTIDE oxidative stress SOMATOSTATIN 
Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy:an overview of pathophysiology,pharmacological targets and candidate drugs focusing on excitotoxicity and free radical被引量：2
《Stroke & Vascular Neurology》2024年第4期351-359,共9页Xiumei Xu Mingyu Chen Dongya Zhu 
supported by grants from the National Natural Science Foundation of China(82090042);the National Key Research and Development Program of China(2021YFA1101803).
Stroke is the second-leading cause of death and the leading cause of disability in much of the world.In particular,China faces the greatest challenge from stroke,since the population is aged quickly.In decades of clin...
关键词：protective injuries DRUGS 
Glutamate and excitotoxicity in central nervous system disorders:ionotropic glutamate receptors as a target for neuroprotection被引量：1
《Neuroprotection》2024年第2期137-150,共14页Jorge Y.Magdaleno Roman Christian Chapa Gonzalez 
Recent advances in neuroscience have illuminated the central role of glutamate dysregulation in various neurological disorders.The glutamatergic system has emerged as a central player in the pathophysiology of various...
关键词：central nervous system EXCITOTOXICITY GLUTAMATE ionotropic glutamate receptors NEUROPROTECTION 
Adenosine A_(2A)receptor blockade attenuates excitotoxicity in rat striatal medium spiny neurons during an ischemic-like insult
《Neural Regeneration Research》2024年第2期255-257,共3页Elisabetta Coppi Federica Cherchi Alasdair J.Gibb 
supported by University of Florence RICATEN 2023 to EC.Grant/Award Numbers 58514_Internazionalizzazione;University of Florence,to EC.Parkinson’s UK,Grant/Award Number:H-0902 to AJG;Wellcome Trust,Grant/Award Number:0926/Z/10/Z to AJG。
During brain ischemia,excitotoxicity and peri-infarct depolarization injuries occur and cause cerebral tissue damage.Indeed,anoxic depolarization,consisting of massive neuronal depolarization due to the loss of membra...
关键词：adenosine A_(2A)receptors anoxic depolarization brain ischemia glutamate excitotoxicity medium spiny neurons oxygen and glucose deprivation 
In vitro protective effect of recombinant prominin-1 combined with microRNA-29b on N-methyl-D-aspartateinduced excitotoxicity in retinal ganglion cells
《International Journal of Ophthalmology(English edition)》2023年第11期1746-1755,共10页Jun-Hua Li Guan-Shun Yu Yu-Da Wang Tian-Kun Li 
Supported by Zhejiang Provincial Natural Science Foundation of China(No.LY20H120003).
AIM:To determine the in vitro protective effect of recombinant prominin-1(Prominin-1)+microRNA-29b(P1M29)on N-methyl-D-aspartate(NMDA)-induced excitotoxicity in retinal ganglion cells(RGCs).METHODS:RGC-5 cells were cu...
关键词：Prominin-1 microRNA-29b vascular endothelial growth factor transforming growth factor-β2 
Adipose mesenchymal stem cell-derived extracellular vesicles reduce glutamate-induced excitotoxicity in the retina被引量：3
《Neural Regeneration Research》2023年第10期2315-2320,共6页Tian-Qi Duan Zhao-Lin Gao Ai-Xiang Luo Dan Chen Jian-Bin Tong Ju-Fang Huang 
supported by the National Key R&D Program of China,No.2016YFC1201800(to JFH);the Key Research and Development Program of Hunan Province,Nos.2018SK2090(to JFH),2022SK2079(to JFH);the Natural Science Foundation of Hu nan Province,No.2021JJ30891(to DC);the Human Resource Bank Program of Hunan Province,No.2020TP3003(to JFH);the School-Enterprise Joint Program of Central South University,No.2021XQLH092(to TQD)。
Adipose mesenchymal stem cells(ADSCs)have protective effects against glutamate-induced excitotoxicity,but ADSCs are limited in use for treatment of optic nerve injury.Studies have shown that the extracellular vesicles...
关键词：adipose mesenchymal stem cells calcium overload ELECTRORETINOGRAPHY EXCITOTOXICITY extracellular vesicles GluA2 GLUTAMATE protein kinase C alpha R28 cells RETINA retinal ganglion cell 
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