SOMATOSTATIN

作品数：160被引量：632H指数：15
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On implications of somatostatin in diabetic retinopathy
《Neural Regeneration Research》2024年第9期1984-1990,共7页Yanhong Fang Qionghua Wang Youjian Li Li Zeng Jian Liu Kepeng Ou 
supported by the Natural Science Foundation of Chongqing of China,Nos.cstc2020jcyj-msxmX0698(to YF),cstc2021jcyjbshX0147(to KO);a grant from Chongqing Jiangjin District Bureau of Science and Technology,No.Y2022017(to YF).
Somatostatin,a naturally produced neuroprotective peptide,depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina.In this review,we summarize the progress of so...
关键词：diabetes retinopathy EXCITOTOXICITY growth hormone insulin like growth factor irisin NEURODEGENERATION NEUROINFLAMMATION neuroprotection neurovascular unit OCTREOTIDE oxidative stress SOMATOSTATIN 
Computerized tomography-guided therapeutic percutaneous puncture catheter drainage-combined with somatostatin for severe acute pancreatitis: An analysis of efficacy and safety被引量：2
《World Journal of Gastrointestinal Surgery》2024年第1期59-66,共8页Xue-Lan Zheng Wan-Ling Li Yan-Ping Lin Ting-Long Huang 
Supported by 2022 Fujian Medical University Qihang Fund General Project Plan,No.2022QH1120。
BACKGROUND Severe acute pancreatitis(SAP),a condition with rapid onset,critical condition and unsatisfactory prognosis,poses a certain threat to human health,warranting optimization of relevant treatment plans to impr...
关键词：Computerized tomography guidance Therapeutic percutaneous puncture catheter drainage SOMATOSTATIN Severe acute pancreatitis Efficacy and safety 
Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia被引量：2
《Signal Transduction and Targeted Therapy》2023年第6期3111-3122,共12页Yang Zheng Cenglin Xu Jinyi Sun Wenjie Ming Sijie Dai Yuying Shao Xiaoyun Qiu Menghan Li Chunhong Shen Jinghong Xu Fan Fei Jiajia Fang Xuhong Jiang Guoqing Zheng Weiwei Hu Yi Wang Shuang Wang Meiping Ding Zhong Chen 
supported by grants from the National Key R&D Program of China(No.2020YFA0803900);the National Natural Science Foundation of China(82071443,81973298,82173796,82022071,82201607);the Natural Science Foundation of Zhejiang Province(LD22H310003,Q23H090002).
Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery,likely due to the widespread seizure network.Previous studies have primarily focused on the disruption of dys...
关键词：SOMATOSTATIN DYSPLASIA SEIZURE 
Impact of antagonist peptides and chelators on the diagnostic performance of PET/CT using gallium-68-labeled somatostatin receptor antagonists
《Journal of Pancreatology》2023年第1期28-33,共6页Haiqun Xing Wenjia Zhu Yuejuan Cheng Qiao Yang Ru Jia Hong Zhao Chunmei Bai Li Huo Wenming Wu 
National Natural Science Foundation of China(No. 82071967);CAMS initiative for innovative medicine(No. CAMS-2018-I2M-3-001);National Key Research and Development Program of China(No. 2016YFC0901500);Center for Rare Diseases Research, Chinese Academy of Medical Sciences, Beijing, China(No. 2016ZX310174-4)。
Objective: Different SSTR2 antagonists have been developed. This study aims to evaluate the impact of different peptides and chelators on the diagnostic performance of SSTR2 antagonists in well-differentiated NETs.Met...
关键词：-DOTA-LM3 68Ga-NODAGA-JR11 68Ga-NODAGA-LM3 Neuroendocrine tumor Somatostatin receptor antagonist 
Somatostatin-Positive Neurons in the Rostral Zona Incerta Modulate Innate Fear-Induced Defensive Response in Mice被引量：3
《Neuroscience Bulletin》2023年第2期245-260,共16页Shan Lin Meng-Yue Zhu Meng-Yu Tang Mi Wang Xiao-Dan Yu Yi Zhu Shi-Ze Xie Dan Yang Jiadong Chen Xiao-Ming Li 
supported by the Science and Technology Innovation 2030-Major Project of Brain Science and Brain-like Research(2021ZD0202700,2021ZD0202702);the Key-Area Research and Development Program of Guangdong Province(2019B030335001,2018B030334001);the Major Program of the National Natural Science Foundation of China(82090030,82090031);the CAMS Innovation Fund for Medical Sciences(2019-12M-5-057);the Ministry of Science and Technology(2019YFA0110103);the National Natural Science Foundation of China(81870898);the Fundamental Research Funds for the Central Universities(2021FZZX001-37);the Zhejiang Provincial Natural Science Foundation(LR18H090002);the Young Scientist Program of the National Natural Science Foundation of China(82001135).
Defensive behaviors induced by innate fear or Pavlovian fear conditioning are crucial for animals to avoid threats and ensure survival.The zona incerta(ZI)has been demonstrated to play important roles in fear learning...
关键词：Innate fear Zona incerta Somatostatinpositive neurons Looming stimulus Defensive behavior 
Impact of antagonist peptides and chelators on the diagnostic performance of PET/CT using gallium-68 labeled somatostatin receptor antagonists
《Journal of Pancreatology》2022年第3期15-39,共25页Haiqun Xing Wenjia Zhu Yuejuan Cheng Qiao Yang Ru Jia Hong Zhao Chunmei Bai Li Huo Wenming Wu 
This work was sponsored in part by the National Natural Science Foundation of China(No.82071967);CAMS initiative for innovative medicine(No.CAMS-2018-I2M-3-001);National Key Research and Development Program of China(No.2016YFC0901500);Center for Rare Diseases Research,Chinese Academy of Medical Sciences,Beijing,China(No.2016ZX310174-4)。
Objective:Different SSTR2 antagonists have been developed.This study aims to evaluate the impact of different peptides and chelators on the diagnostic performance of SSTR2 antagonists in well-differentiated NETs.Metho...
关键词：Somatostatin receptor antagonist 68Ga-NODAGA-LM3 68Ga-DOTA-LM3 68Ga-NODAGA-JR11 neuroendocrine tumor 
Structural Insights into Ligand Recognition and Selectivity of Somatostatin Receptors
《Bulletin of the Chinese Academy of Sciences》2022年第2期73-74,共2页
Somatostatin is a hormone that regulates multiple hormone releases and cell proliferation in the human body.It does this through a group of somatostatin receptors(SSTRs),of which there are five types:SSTR1-SSTR5.SSTR2...
关键词：SOMATOSTATIN RECEPTOR TARGETED 
Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer’s disease被引量：1
《Translational Neurodegeneration》2022年第1期566-587,共22页Christopher Daniel Morrone Aaron Yenhsin Lai Jossana Bishay Mary Elizabeth Hill JoAnne McLaurin 
the Canadian Institutes of Health Research Project Grant,PJY155983(J.M.);Canada Research Chairs Program(J.M.)and National Institutes of Health R01 AG057665-02(J.M.).
Background: Patient-to-patient variability in the degree to which β-amyloid, tau and neurodegeneration impact cognitive decline in Alzheimer’s disease (AD) complicates disease modeling and treatment. However, the un...
关键词：Alzheimer’s disease TgF344-AD rat GABAergic interneuron PARVALBUMIN SOMATOSTATIN Barnes maze Hippocampus Neuronal compensation Cognitive resilience 
Somatostatin 1在斑马鱼早期发育过程中原杂定位及对葡萄糖刺激的表达反应
《基因组学与应用生物学》2022年第2期250-256,共7页曹蕾 于茜 赵文婷 Adelino Canario 陈洁 
上海海洋大学水产一流学科基金项目(A1-2006-20-7004)资助
生长抑素(somatostatin,ss)是脊椎动物生长发育调控中一种重要的多肽类激素,影响着脊椎动物的生长、发育、繁殖和代谢等方面。斑马鱼(Danio rerio)中共有6个生长抑素基因(ss1-ss6),这些基因对斑马鱼糖代谢调控作用还鲜有报道。本研究以...
关键词：生长抑素 糖代谢 表达定位 斑马鱼 
Somatostatin 3 loss of function impairs the innate immune response to intestinal inflammation被引量：1
《Aquaculture and Fisheries》2021年第6期548-557,共10页Jing Ma Jie Chen Bruno Louro Rute S.T.Martins Adelino V.M.Canario 
This research was supported by the Shanghai Ocean University First-Class Disciplines Project of Fisheries,the open project of the International Research Center for Marine Biosciences(Ministry of Science and Technology);the International Research Group Program at Shanghai Ocean University,and Portuguese national funds from FCT-Foundation for Science and Technology through project UIDB/04326/2020;RSTM was funded by FCT-Foundationfor Science and Technology-I.P.,under the contracts Norma transitoria-DL57/2016/CP1361/CT0021 with the University of Algarve.
Somatostatin is a neuropeptide and a key regulator of the growth axis.Six Sst encoding genes(sst1 to sst6)have been identified in teleost fish genomes but little is known about their function.The present study aimed a...
关键词：Somatostatin 3 ZEBRAFISH IBD INFLAMMATION RNA-SEQ 
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