Computerized tomography-guided therapeutic percutaneous puncture catheter drainage-combined with somatostatin for severe acute pancreatitis: An analysis of efficacy and safety  

作　　者：Xue-Lan Zheng Wan-Ling Li Yan-Ping Lin Ting-Long Huang 

机构地区：[1]Department of Critical Care Medicine,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian Province,China [2]CT Room,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第1期59-66,共8页世界胃肠外科杂志（英文版）（电子版）

基　　金：Supported by 2022 Fujian Medical University Qihang Fund General Project Plan,No.2022QH1120。

摘　　要：BACKGROUND Severe acute pancreatitis(SAP),a condition with rapid onset,critical condition and unsatisfactory prognosis,poses a certain threat to human health,warranting optimization of relevant treatment plans to improve treatment efficacy.AIM To evaluate the efficacy and safety of computerized tomography-guided the-rapeutic percutaneous puncture catheter drainage(CT-TPPCD)combined with somatostatin(SS)in the treatment of SAP.METHODS Forty-two SAP patients admitted to The Second Affiliated Hospital of Fujian Medical University from June 2020 to June 2023 were selected.On the basis of routine treatment,20 patients received SS therapy(control group)and 22 patients were given CT-TPPCD plus SS intervention(research group).The efficacy,safety(pancreatic fistula,intra-abdominal hemorrhage,sepsis,and organ dysfunction syndrome),abdominal bloating and pain relief time,bowel recovery time,hospital stay,inflammatory indicators(C-reactive protein,interleukin-6,and pro-calcitonin),and Acute Physiology and Chronic Health Evaluation(APACHE)II score of both groups were evaluated for comparison.RESULTS Compared with the control group,the research group had a markedly higher total effective rate,faster abdominal bloating and pain relief and bowel recovery,INTRODUCTION Pancreatitis,an inflammatory disease occurring in the pancreatic tissue,is classified as either acute or chronic and is associated with high morbidity and mortality,imposing a socioeconomic burden[1,2].The pathogenesis of this disease involves early protease activation,activation of nuclear factor kappa-B-related inflammatory reactions,and infiltration of immune cells[3].Severe acute pancreatitis(SAP)is a serious condition involving systemic injury and subsequent possible organ failure,accounting for 20%of all acute pancreatitis cases[4].SAP is also characterized by rapid onset,critical illness and unsatisfactory prognosis and is correlated with serious adverse events such as systemic inflammatory response syn-drome and acute lung injury,threatening the health of pa

关 键 词：Computerized tomography guidance Therapeutic percutaneous puncture catheter drainage SOMATOSTATIN Severe acute pancreatitis Efficacy and safety 

分 类 号：R657.51[医药卫生—外科学]