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Neural functional rehabilitation:Exploring neuromuscular reconstruction technology advancements and challenges
《Neural Regeneration Research》2026年第1期173-186,共14页Chunxiao Tang Ping Wang Zhonghua Li Shizhen Zhong Lin Yang Guanglin Li 
supported in part by the National Natural Science Foundation of China,Nos.81927804(to GL),82260456(to LY),U21A20479(to LY);Science and Technology Planning Project of Shenzhen,No.JCYJ20230807140559047(to LY);Key-Area Research and Development Program of Guangdong Province,No.2020B0909020004(to GL);Guangdong Basic and Applied Research Foundation,No.2023A1515011478(to LY);the Science and Technology Program of Guangdong Province,No.2022A0505090007(to GL);Ministry of Science and Technology,Shenzhen,No.QN2022032013L(to LY)。
Neural machine interface technology is a pioneering approach that aims to address the complex challenges of neurological dysfunctions and disabilities resulting from conditions such as congenital disorders,traumatic i...
关键词：agonist–antagonist myoneural interface biocompatibility brain–machine interface clinical anatomy neural machine interface NEUROPROSTHETICS peripheral nerve interface PROPRIOCEPTION targeted muscle reinnervation targeted sensory reinnervation 
Alzheimer's disease treatment landscape:current therapies and emerging mechanism-targeted approaches
《Neural Regeneration Research》2025年第12期3531-3532,共2页Eleen Yang Khaled S.Abd-Elrahman 
supported by a New Investigator grant from the Alzheimer’s Society of Canada;research grant from Djavad Mowafaghian Centre for Brain Health to KSAE。
Alzheimer's disease (AD) is an age-related neurodegenerative disease that involves a progressive decline in memory,thinking,a nd learning.AD has been studied rigorously for more than 50 years yet there is a marked lac...
关键词：ALZHEIMER diagnosis LANDSCAPE 
Promising roles of vitamin D receptor and APRO family proteins for the development of cancer stem cells targeted malignant tumor therapy
《Oncology Research》2025年第5期1007-1017,共11页MOEKA NAKASHIMA NAOKO SUGA AKARI FUKUMOTO SAYURI YOSHIKAWA SATORU MATSUDA 
Malignant tumors are heterogeneous diseases characterized by uncontrolled cell proliferation,invasion,metastasis,and/or recurrence of their malignancies.In particular,cancer stem cells(CSCs)within these tumors might b...
关键词：Vitamin D Cancer stem cell INVASION METASTASIS CHEMORESISTANCE Ferroptosis Tumor microenvironment Noncoding RNAs Cancer therapy 
Clinical Application of Imaging Navigation Technology in the Treatment of Pulmonary Tuberculosis
《Journal of Clinical and Nursing Research》2025年第4期370-376,共7页Yanju Su Peng Wang Hui Jiang Dianhai Zhong Qiuye Ma Mingjun Huang 
Science and Education Department Harbin Health Committee Project。
Objective:To observe the guiding role of image navigation technology in the treatment of patients with tuberculosis.Methods:A total of 188 patients with multidrug-resistant tuberculosis(MDR-TB)and rifampin-resistant t...
关键词：Image navigation DSA BRONCHOSCOPY Targeted infusion therapy MDR-TB RR-TB 
Pretreatment radiomic imaging features combined with immunological indicators to predict targeted combination immunotherapy response in advanced hepatocellular carcinoma
《World Journal of Clinical Oncology》2025年第4期154-164,共11页Xu Zhang Xu Zhang Qian-Kun Luo Qiang Fu Pan Liu Chang-Jie Pan Chuan-Jiang Liu Hong-Wei Zhang Tao Qin 
Supported by Natural Science Foundation of Henan Province,No.242300421286;the research and practice project of higher education reform in Henan Province,No.2023SJGLX124Y;the research and practice project of higher education reform of Zhengzhou University,No.2023ZZUJGXM114.
BACKGROUND Early symptoms of hepatocellular carcinoma(HCC)are not obvious,and more than 70%of which does not receive radical hepatectomy,when first diagnosed.In recent years,molecular-targeted drugs combined with immu...
关键词：Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid Hepatocellular carcinoma Targeted combination immunotherapy Relative hepatobiliary enhancement ratio Effect prediction 
Stereoselective effects and its potential mechanism of ofloxacin on the growth and development of Rana nigromaculata:mainly liver lipid metabolism
《Frontiers of Environmental Science & Engineering》2025年第4期125-138,共14页Wenjun Zhang Miaomiao Teng Jin Yan 
supported by the National Natural Science Foundation of China(No.42207321);the Fundamental Research Funds for the Central Universities(China)(No.B230201006).
Most research on antibiotics in the environment disregards chiral antibiotics,such as ofloxacin(OF).In this study,tadpoles of Rana nigromaculata were exposed to 1μg/L OF and levofloxacin(LVFX,an enantiomer of OF)for ...
关键词：Chiral antibiotics AMPHIBIANS Targeted metabolomics Molecular docking OBESITY 
Oxygen heterocyclic compounds(OHCs)in lemon oils are important markers in targeted HPLC analyses for authentication
《Food Science and Human Wellness》2025年第2期421-428,共8页Siyu Liu Shiming Li Chi-Tang Ho 
Lemon oils are broadly used as flavoring agents in beverages,foods,cosmetics and pharmaceuticals,yet the adulteration of natural,particularly cold pressed lemon oils is very common in the industry due to its unmet dem...
关键词：Lemon oils Oxygen heterocyclic compounds High performance liquid chromatography(HPLC) AUTHENTICITY Targeted analysis Quality control 
Robust federated contrastive recommender system against targeted model poisoning attack
《Science China(Information Sciences)》2025年第4期46-61,共16页Wei YUAN Chaoqun YANG Liang QU Guanhua YE Quoc Viet Hung NGUYEN Hongzhi YIN 
supported by Australian Research Council under the Streams of Future Fellowship(Grant No.FT210100624);Discovery Project(Grant No.DP240101108);Linkage Project(Grant No.LP230200892)。
Federated recommender systems(FedRecs)have garnered increasing attention recently,thanks to their privacypreserving benefits.However,the decentralized and open characteristics of current FedRecs present at least two d...
关键词：federated recommender system contrastive learning model poisoning attack and defense 
Covalent multi-targeted radiopharmaceuticals for enhanced tumor theranostics
《Science China Chemistry》2025年第4期1456-1467,共12页Yirui Guo Zhengzhong Lv Yuqi Zhang Zhongsheng Zhao Yurong Fan Yan Chen Miao Li Xingxiang Ren Yiming Feng Zhixin Han Hongyuan Wen Guohua Fan Ru Yang Haibin Shi 
supported by the National Natural Science Foundation of China(T2325019,22077092);the Basic Research Program of Jiangsu(BK20243030);the Special Project of“Technological Innovation”Project of CNNC Medical Industry Co.Ltd.(ZHYLYB2021001);the Four“Batches"Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province(2022XM19);the Open Project Program of the State Key Laboratory of Radiation Medicine and Protection(GZK12024016,GZK12023050,GZK12024013);a Project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Tumor-targeted radiopharmaceuticals have become an attractive modality for tumor diagnosis and treatment in clinics.However;their wide clinical applications are seriously impeded by poor tumor targeting;rapid systemic...
关键词：covalent targeted radiopharmaceuticals sulfenated protein nuclear imaging lung cancer THERANOSTICS 
T helper 17 cells and interleukin-17 immunity in type 1 diabetes:From pathophysiology to targeted immunotherapies
《World Journal of Diabetes》2025年第4期48-61,共14页Georgi Vasilev Maria Kokudeva Elina Siliogka Nathalia Padilla Russka Shumnalieva David Della-Morte Camillo Ricordi Antoaneta Mihova Marco Infante Tsvetelina Velikova 
Supported by the European Union-NextGenerationEU,through the National Recovery and Resilience Plan of the Republic of Bulgaria,No.BG-RRP-2.004-0008.
Type 1 diabetes(T1D)is a chronic organ-specific autoimmune disorder characterized by a progressive loss of the insulin-secreting pancreatic beta cells,which ultimately results in insulinopenia,hyperglycemia and lifelo...
关键词：Type 1 diabetes T helper 17 cells INTERLEUKIN-17 T helper 1 cells Regulatory T cells Anti-interleukin-17 treatment Th17-targeted treatment 
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