Promising roles of vitamin D receptor and APRO family proteins for the development of cancer stem cells targeted malignant tumor therapy  

作　　者：MOEKA NAKASHIMA NAOKO SUGA AKARI FUKUMOTO SAYURI YOSHIKAWA SATORU MATSUDA 

机构地区：[1]Department of Food Science and Nutrition,Nara Women’s University,Kita-Uoya Nishimachi,Nara,630-8506,Japan

出　　处：《Oncology Research》2025年第5期1007-1017,共11页肿瘤学研究(英文)

摘　　要：Malignant tumors are heterogeneous diseases characterized by uncontrolled cell proliferation,invasion,metastasis,and/or recurrence of their malignancies.In particular,cancer stem cells(CSCs)within these tumors might be responsible for the property of invasiveness and/or therapies-resistance.CSCs are a self-renewing,awfully tumorigenic subpopulation of cancer cells,which are notorious for strong chemoresistance and are frequently responsible the aggravated invasion,metastasis,and/or recurrence.Developing targeting therapies against CSCs,therefore,may be deliberated a more encouraging mission for the greater cancer therapy.Innovation for a more potent anti-CSC treatment has been required as soon as possible.Interestingly,vitamin D could modulate the inflammatory condition of the tumor microenvironment(TME)by successfully affecting CSCs,which has an imperative role in determining the malignant phenotype of CSCs.In addition,vitamin D may also contribute to the regulation of the malignant behaviors of CSCs.Consistently,vitamin D could have potential applications for the significant inhibition of several tumor growths within various cancer therapies.The biological significance of vitamin D for CSCs regulation may be involved in the function of APRO family proteins.Therefore,vitamin D could be one of the innovative therapeutic modalities for the development of novel CSCs related tumor therapies.

关 键 词：Vitamin D Cancer stem cell INVASION METASTASIS CHEMORESISTANCE Ferroptosis Tumor microenvironment Noncoding RNAs Cancer therapy 

分 类 号：R730.5[医药卫生—肿瘤]