BIOCONJUGATE

作品数：7被引量：7H指数：1
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The impact of N-terminal modification of PAA with different chain lengths on the structure,thermal stability and pH sensitivity of succinylated collagen
《Collagen and Leather》2024年第2期93-103,共11页Juntao Zhang Yang Liu Haofei Xu Peishan Sui Tianyi Liu Mingming Zheng Evgeny AShirshin Benmei Wei Chengzhi Xu Haibo Wang 
supported by the National Natural Science Foundation of China(Nos.22378320,22178277,21706201);Knowledge Innovation Program of Wuhan-Basi Research,China(No.2023020201010148);Appli cation Foundation Frontier Project of Wuhan Science and Technology Bureau,China(No.2019020701011478).
The limitations of native collagen,such as thermal stability and solubility in physiological environments,can be improved by applying bioconjugation and synthetic chemistry techniques.However,the exquisite control of ...
关键词：Succinylated collagen-PAA bioconjugate Polymer chain length Thermal stability 
Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer被引量：1
《Journal of Pharmaceutical Analysis》2022年第2期232-242,共11页Yang-Yang Wang Liang Li Xiu-Jun Liu Qing-Fang Miao Yi Li Meng-Ran Zhang Yong-Su Zhen 
supported by grants from CAMS Innovation Fund for Medical Sciences(Grant No.:2021-I2M-1-026);Scientific Research Project of Tianjin Education Commission(Grant No.:2020KJ140);Tianjin Health Research Project(Grant No.:KJ20017)。
Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmo...
关键词：Pancreatic cancer Folate receptor Multi-functional Macropinocytosis-enhanced BIOCONJUGATE K-RAS PEGYLATION 
Native conjugation between proteins and [60]fullerene derivatives using SpyTag as a reactive handle被引量：1
《Chinese Chemical Letters》2021年第1期353-356,共4页Guangzhong Yin Jingjing Wei Yu Shao Wen-Hao Wu Lianjie Xu Wen-Bin Zhang 
the financial support from the National Natural Science Foundation of China(Nos.21925102,21991132 and 21674003);supported by Beijing National Laboratory for Molecular Sciences(No.BNLMS-CXXM-202006);Clinical Medicine Plus X Project of Peking University,Fundamental Research Funds for the Central Universities。
Herein,we report the facile conjugation between proteins and water-soluble [60]fullerene derivatives(DC_(60)) under native conditions using SpyTag as a reactive handle.Water-soluble [60] fullerene derivatives were fir...
关键词：SpyTag Spy Catcher FULLERENE Protein BIOCONJUGATE 
Bioconjugate structures vs. composite nanoparticulate carriers: the battle for the future of smart, effective and safe cancer management
《Journal of Cancer Metastasis and Treatment》2018年第1期348-350,共3页Mohamed Ismail Nounou 
For the past couple of decades,academic research has been mainly focusing on novel carrier systems and nanoparticulate colloidal technologies for drug delivery,such as nanoparticles,nanospheres,vesicular systems,lipos...
关键词：COMPOSITE CONJUGATE NANOPARTICLES 
Fluorescent Detection of Cu(Ⅱ) by Chitosan-based AIE Bioconjugate被引量：1
《Chinese Journal of Polymer Science》2017年第3期365-371,共7页Ya-lan Liu 王征科 Wei Qin 胡巧玲 唐本忠 
financially supported by the Key Science Technology Innovation Team of Zhejiang Province(No.2013TD02);the National Natural Science Foundation of China(Nos.21104067,21274127,21374099 and 51473144)
Detection of Cu（Ⅱ） is very important in disease diagnose, biological system detection and environmental monitoring. Previously, we found that the product TPE-CS prepared by attaching the chromophores of tetrapheny...
关键词：Aggregation-induced emission CHITOSAN Cu(Ⅱ) Fluorescent detection 
Norvancomycin-capped silver nanoparticles: Synthesis and antibacterial activities against E. coli被引量：3
《Science China Chemistry》2007年第3期418-424,共7页WEI QingShan JI Jian FU JinHong SHEN JiaCong 
Supported by the National Natural Science Foundation of China (Grant No. 50373036);Fok Ying Tung Education Foundation (Grant No. J20040212)
The synthesis of norvancomycin (NVan)-capped silver nanoparticles (Ag@NVan) and their notable in vitro antibacterial activities against E. coli, a Gram-negative bacterial strain (GNB), are reported here. Mercaptoaceti...
关键词：silver nanoparticle NORVANCOMYCIN GRAM-NEGATIVE BACTERIAL strain BIOCONJUGATE 
Studies on a Novel Minor-groove Targeting Artificial Nuclease:Synthesis and DNA Binding Behavior被引量：1
《Chemical Research in Chinese Universities》2007年第1期44-47,共4页YIN Qiang ZHANG Zhen ZHAO Yu-fen 
Supported by the National Natural Science Foundation of China(Nos 20132020 and 20572061), the National Science andTechnology Committee of China, the National Ministry of Education of China, and Tsinghua University
Nucleases play an important role in molecular biology, for example, in DNA sequencing. Synthetic polyamide conjugates can be considered as a novel tool for the selective inhibition of gene expressions and also as pote...
关键词：Calf thymus DNA POLYAMIDE BIOCONJUGATE UV-Vis spectroscopy Circular dichroism 
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