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CONJUGATE: 作品数：474被引量：675H指数：11; 导出分析报告; 相关领域：理学更多>>; 相关作者：赵燕军廖桂生周争光朱圣棋郑经纬更多>>; 相关机构：北京大学清华大学复旦大学天津大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家教育部博士点基金更多>>

Conjugate Usage of Experimental for and Theoretical Models Aqua Carboxymethyl Cellulose Nanofluid Flow in Convergent-Divergent Shaped Microchannel: 《Frontiers in Heat and Mass Transfer》2025年第2期663-684,共22页Shervin Fateh Khanshir Saeed Dinarvand Ramtin Fateh Khanshir; This article aims tomodel and analyze the heat and fluid flow characteristics of a carboxymethyl cellulose(CMC)nanofluid within a convergent-divergent shaped microchannel(Two-dimensional).The base fluid,water+CMC(0.5%...; 关键词：Convergent-divergent microchannel CMC-base nanofluid non-Newtonian numerical simulation experimental model

Thio-ProTide strategy:A novel H_(2)S donor-drug conjugate(DDC)alleviates hepatic injury via innate lysosomal targeting: 《Acta Pharmaceutica Sinica B》2024年第12期5341-5356,共16页Haowen Jin Jie Ma Bixin Xu Sitao Xu Tianyu Hu Xin Jin Jiankun Wang Guangji Wang Le Zhen; supported by the National Natural Science Foundation of China(grant No.82173686);CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-5-011,China);Leading Technology Foundation Research Project of Jiangsu Province(BK20192005,China);Outstanding Youth Foundation of Jiangsu Province(No.BK20200081,China).; Hydrogen sulfide(H_(2)S)is a gas signaling molecule with versatile bioactivities;however,its exploitation for disease treatment appears challenging.This study describes the design and characteriza-tion of a novel type...; 关键词：ProTide prodrug Hydrogen sulfide donor Drug conjugate Cellular pharmacokinetics Liver fibrosis Lipid peroxidation Lysosomal targeting Prodrug activation

A self-assembled affibody-PROTAC conjugate nanomedicine for targeted cancer therapy: 《Nano Research》2024年第11期9954-9964,共11页Qingrong Li Xiaoyuan Yang Mengqiao Zhao Xuelin Xia Wenhui Gao Wei Huang Xiaoxia Xia Deyue Yan; supported by the National Natural Science Foundation of China(NOs.22201178,and 32071414);the National Key Research and Development Program of China(No.2020YFA0907702).; Proteolysis targeting chimeras (PROTACs) have recently emerged as promising therapeutic agents for cancer therapy. However, their clinical application is considerably hindered by the poor membrane permeability and ins...; 关键词：amphiphilic affibody-PROTAC conjugate BRD4 degradation NANOMEDICINE SELF-ASSEMBLY targeted cancer therapy

5-year vaccine protection following a single dose of Vi-tetanus toxoid conjugate vaccine in Bangladeshi children(TyVOID):a cluster randomised trial: 《四川生理科学杂志》2024年第10期2360-2360,共1页Firdausi Qadri; Background:WHO currently recommends a single dose of typhoid conjugate vaccine(TCV)in high-burden countries based on 2-year vaccine efficacy data from large randomised controlled trials.Given the decay of immunogenici...; 关键词：CONJUGATE random CLUSTER

Modelling Method and Meshing Characteristics of a Novel Curve-Surface Conjugate Internal Gear Drive: 《Chinese Journal of Mechanical Engineering》2024年第5期216-232,共17页Xinxin Ye Luhe Zhang Dongyu Wang Jingming Jiang Wenjun Luo Bingkui Chen; Supported by Major Projects in Aviation Engines and Gas Turbines(Grant No.J2019-IV-0001-0068).; Space exploration has become a major focus in the field of technology,with gear transmissions in aerospace equipment playing a crucial role.In the extreme environment of space,gear transmissions face challenges like l...; 关键词：Internal gear drive Tooth surface geometry Error adaptability Transmission efficiency

A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus: 《Acta Pharmaceutica Sinica B》2024年第10期4560-4576,共17页Lai Wang Haoyuan Yin Jiao Jiang Qilin Li Changxing Gao Wenrui Li Bo Zhang Yue Xin Hongyang Li Ming Zhao Qianjin Lu; supported by the National Key R&D Program of China(2022YFC3601800 to Qianjin Lu);the National Natural Science Foundation of China(No.82304509 to Lai Wang);the Natural Science Foundation of Jiangsu Province(BK20230131 to Lai Wang);the Special Program of National Natural Science Foundation of China(No.32141004 to Qianjin Lu);the CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-059 to Qianjin Lu,China);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020-RC320-003 to Qianjin Lu).; Tripterygium wilfordii Hook F(TWHF)is a traditional Chinese medicine widely used in the treatment of systemic lupus erythematosus(SLE),with triptolide(TP)as its main active ingredient.However,its side effects also ind...; 关键词：Systemic lupus erythematosus TRIPTOLIDE CD19 Antibody‒drug conjugate B cells Reproductive toxicity Synergistic effect Targeted therapy

Magnetohydrodynamic Conjugate Free Convective Heat Transfer Analysis of an Isothermal Horizontal Circular Cylinder with Temperature Dependent Viscosity: 《Journal of Applied Mathematics and Physics》2024年第10期3384-3401,共18页NHM. A. Azim; Heat transfers due to MHD-conjugate free convection from the isothermal horizontal circular cylinder while viscosity is a function of temperature is investigated. The governing equations of the flow and connected boun...; 关键词：Conjugate Free Convection Horizontal Circular Cylinder Implicit Finite Difference Method MHD Temperature Dependent Viscosity

Conjugate adaptive optics extension for commercial microscopes: 《Advanced Photonics Nexus》2024年第5期182-189,共8页Alex Dorn Hans Zappe Çag lar Ataman; We present what we believe is the first conjugate adaptive optics(AO)extension that can be retrofitted into a commercial microscope by being positioned between the camera port and the image sensor.The extension featur...; 关键词：adaptive optics MICROSCOPY deformable phase plate

BOUNDARY VALUE PROBLEMS OF CONJUGATE AND GENERALIZED K-HOLOMORPHIC FUNCTIONS IN C^(2): 《Acta Mathematica Scientia》2024年第5期1837-1852,共16页Yanyan CUI Chaojun WANG Yonghong XIE Yuying QIAO; supported by the NSF of Henan Province(222300420397,242300421394);Xie’s research was supported by the NSFC(11571089,11871191).; In this paper,conjugate k-holomorphic functions and generalized k-holomorphic functions are defined in the two-dimensional complex space,and the corresponding Riemann boundary value problems and the inverse problems a...; 关键词：several complex variables k-holomorphic functions partial difference equations polyanalytic functions

本刊英文版Vol.40(2024),No.7论文摘要: 《数学学报（中文版）》2024年第5期I0001-I0008,共8页; Deformation of Rigid Conjugate Self-dual Galois Representations Yi Feng LIU Yi Chao TIAN Liang XIAO Wei ZHANG Xin Wen ZHU Abstract In this article,we study deformations of conjugate self-dual Galois representations.Th...; 关键词：CONJUGATE GALOIS satisfying

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