TRIPTOLIDE

作品数：119被引量：554H指数：14
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相关机构：首都医科大学浙江省人民医院中国科学院上海生命科学研究院南京大学更多>>
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A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus
《Acta Pharmaceutica Sinica B》2024年第10期4560-4576,共17页Lai Wang Haoyuan Yin Jiao Jiang Qilin Li Changxing Gao Wenrui Li Bo Zhang Yue Xin Hongyang Li Ming Zhao Qianjin Lu 
supported by the National Key R&D Program of China(2022YFC3601800 to Qianjin Lu);the National Natural Science Foundation of China(No.82304509 to Lai Wang);the Natural Science Foundation of Jiangsu Province(BK20230131 to Lai Wang);the Special Program of National Natural Science Foundation of China(No.32141004 to Qianjin Lu);the CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-059 to Qianjin Lu,China);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020-RC320-003 to Qianjin Lu).
Tripterygium wilfordii Hook F(TWHF)is a traditional Chinese medicine widely used in the treatment of systemic lupus erythematosus(SLE),with triptolide(TP)as its main active ingredient.However,its side effects also ind...
关键词：Systemic lupus erythematosus TRIPTOLIDE CD19 Antibody‒drug conjugate B cells Reproductive toxicity Synergistic effect Targeted therapy 
Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer被引量：1
《Acta Pharmacologica Sinica》2024年第5期1060-1076,共17页Ling-bing Li Ling-xiao Yang Lei Liu Fan-rong Liu Alex H.Li Yi-lin Zhu Hao Wen Xia Xue Zhong-xian Tian Hong Sun Pei-chao Li Xiao-gang Zhao 
supported by the National Natural Science Foundation of China(No.81874396);Ji-nan Clinical Medicine Research Program for Thoracic Cancer(No.201912007);a grant from the Special Construction Project Fund for Taishan Scholars of Shandong Province.
Paclitaxel resistance is associated with a poor prognosis in non-small cell lung cancer(NSCLC)patients,and currently,there is no promising drug for paclitaxel resistance.In this study,we investigated the molecular mec...
关键词：non-small cell lung cancer paclitaxel resistance TRIPTOLIDE ABCB1 HNF1A Sonic Hedgehog 
Silencing ribosomal protein L4 enhances the inhibitory effects of triptolide on non-small cell lung cancer cells by disrupting the mouse double minute 2 protein–P53 tumor suppressor pathway
《BIOCELL》2023年第9期2009-2026,共18页NAN TANG YAJING ZHAN JIAYAN MAO ANKANG YIN WEI WANG JUAN WANG 
supported by the National Natural Science Foundation of China(Grant Nos.82004007 and 81774026).
Non-small cell lung cancer(NSCLC)is a malignant tumor with high incidence worldwide.Triptolide(TP),extracted from Tripterygium wilfordii Hook F,exhibits potent broad-spectrum antitumor activity.Although some mechanism...
关键词：NSCLC RPL4 TRIPTOLIDE Proteomics Transcriptome 
A single-cell landscape of triptolide-associated testicular toxicity in mice被引量：2
《Journal of Pharmaceutical Analysis》2023年第8期880-893,共14页Wei Zhang Siyu Xia Jinhuan Ou Min Cao Guangqing Cheng Zhijie Li Jigang Wang Chuanbin Yang 
supported by grants from the National Key Research and Development Program of China(Grant Nos.:2020YFA0908000,2022YFC2303600);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.:ZYYCXTD-C-202002);the National Natural Science Foundation of China(Grant Nos.:82201786,82141001,82274182,82074098,82173914);the CACMS Innovation Fund(Grant Nos.:CI2021A05101,CI2021A05104);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(Grant No.:CI2021B014);the Science and Technology Foundation of Shenzhen(Grant Nos.:JCYJ20220818102613029,JCYJ20210324114014039,JCYJ20210324115800001);Guangdong Basic and Applied Basic Research Foundation(Grant Nos.:2020A1515110549,2021A1515110646);the Science and Technology Foundation of Shenzhen(Shenzhen Clinical Medical Research Center for Geriatric Diseases);the National Key R&D Program of China Key projects for international cooperation on science,technology and innovation(Grant No.:2020YFE0205100);and the Fundamental Research Funds for the Central Public Welfare Research Institutes(Grant Nos.:ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-ND-010,ZZ15-ND-10).
Triptolide is a key active component of the widely used traditional Chinese herb medicine Tripterygium wilfordii Hook.F.Although triptolide exerts multiple biological activities and shows promising efficacy in treatin...
关键词：Single-cell sequence TRANSCRIPTOMICS TRIPTOLIDE Reproduction toxicity TESTIS 
The status of fertility control for rodents—recent achievements and future directions被引量：4
《Integrative Zoology》2022年第6期964-980,共17页Kyra JACOBLINNERT Jens JACOB Zhibin ZHANG Lyn A.HINDS 
funded by the German Federal Ministry of Food and Agriculture due to a parliamentary resolution within the federal program“Organic farming and other forms of sustainable agriculture”(grant#2815NA113);the External Cooperation Program,Chinese Academy of Sciences(grant#152111KYSB20150023,GJHZ1797).
Management of overabundant rodents at a landscape scale is complex but often required to sustainably reduce rodent abundance below damage thresholds.Current conventional techniques such as poisoning are not species sp...
关键词：ecologically based rodent management LEVONORGESTREL QUINESTROL TRIPTOLIDE 4-vinylcyclohexene diepoxide 
Integrating systematic pharmacology-based strategy and experimental validation to explore mechanism of Tripterygium glycoside on cholangiocyte-related liver injury被引量：6
《Chinese Herbal Medicines》2022年第4期563-575,共13页Yajing Li Sen Li Xiaoyong Xue Ting Wang Xiaojiaoyang Li 
supported by grants from Beijing Nova Program of Science&Technology(Grant No.Z191100001119088 to XL);Beijing Municipal Science&Technology Commission(Grant No.7212174 to XL);National Natural Science Foundation of China(Grant No.82004045 to XL);Young Talents Promotion Project of China Association of Traditional Chinese Medicine(Grant No.2020-QNRC2-01 to XL);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.ZYYCXTD-C-202006 to XL)。
Objective:Tripterygium glycoside(TG)is widely used in clinical practice for its multiple bioactivities including anti-inflammatory and immunosuppressive effects.However,emerging studies have frequently reported TG-ind...
关键词：cell apoptosis CHOLANGIOCYTE liver injury Tripterygium glycoside TRIPTOLIDE 
A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy被引量：5
《Asian Journal of Pharmaceutical Sciences》2022年第2期206-218,共13页Yihan Wu Jingjing Li Xuemei Zhong Jinfeng Shi Yanfen Cheng Chenglin He Jiaxin Li Liang Zou Chaomei Fu Meiwan Chen Jinming Zhang Huile Gao 
supported by National Natural Science Foundation of China (No.81973662);Distinguished Young Scholar of Sichuan Provincial Science and Technology Department (No.2019JDJQ0049);111 Project (No.B18035)
The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effe...
关键词：TRIPTOLIDE Chemo-photodynamic pH-sensitive supramolecular Nanosystem CO-DELIVERY 
Triptolide protects against white matter injury induced by chronic cerebral hypoperfusion in mice被引量：4
《Acta Pharmacologica Sinica》2022年第1期15-25,共11页Yu-shan Wan Yi You Qian-yun Ding Yi-xin Xu Han Chen Rong-rong Wang Yu-wen Huang Zhong Chen Wei-wei Hu Lei Jiang 
This work was supported by the Zhejiang Provincial Natural Science Foundation of China under Grants No.LR17H310001,and the National Natural Science Foundation of China(81803502,81722045),and the Fundamental Research Funds for the Central Universities.
White matter injury is the major pathological alteration of subcortical ischemic vascular dementia(SIVD)caused by chronic cerebral hypoperfusion.It is characterized by progressive demyelination,apoptosis of oligodendr...
关键词：TRIPTOLIDE chronic cerebral hypoperfusion white matter injury microglial activation right unilateral common carotid artery occlusion(rUCCAO) OLIGODENDROCYTE 
Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2-p65 pathway被引量：4
《Frontiers of Medicine》2021年第5期750-766,共17页Manling Liu Zhaoling Shi Yue Yin Yishi Wang Nan Mu Chen Li Heng Ma Qiong Wang 
This work was supported by the following grants:National Natural Science Foundation of China(Nos.31671424,91749108,and 81322004 to Heng Ma;No.81200036 to Manling Liu);the Science and Technology Research and Development Program of Shaanxi Province,China(No.2015KW-050 to Heng Ma,No.2019SF-008 to Manling Liu,and No.2018SF-101 to Nan Mu);the Youth Innovation Team of Shaanxi Universities,China(to Heng Ma,Yue Yin,Nan Mu,Yishi Wang).
Exposure to particulate matter 2.5(PM2.5)potentially triggers airway inflammation by activating nuclear factor-κB(NF-κB).Sirtuin 2(SIRT2)is a key modulator in inflammation.However,the function and specific mechanism...
关键词：particulate matter 2.5 sirtuin 2 P65 airway inflammation bronchial hyperresponsiveness TRIPTOLIDE 
Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibitingβ-catenin-mediated epithelial–mesenchymal transition被引量：16
《Acta Pharmacologica Sinica》2021年第9期1486-1497,共12页Qiu-di Deng Xue-ping Lei Yi-hang Zhong Min-shan Chen Yuan-yu Ke Zhan Li Jing Chen Li-juan Huang Yu Zhang Lu Liang Zhong-xiao Lin Qing Liu Song-pei Li Xi-yong Yu 
the National Natural Science Foundation of China(No.81330007 and U1601227 to XYY);the Science and Technology Program of Guangzhou(202002030026 to XPL);the Traditional Chinese Medicine Program of Guangdong(20201208 to XPL);the Medical Science and Technology Research Foundation of Guangdong Province(A2020289 to XPL);the Traditional Chinese Medicine Program of Guangdong(20212126 to QDD);Research Projects of Guangzhou Education Bureau(202032845 to QDD);the National Natural Science Foundation of China(No.81903607 to SPL).
Non-small cell lung cancer(NSCLC)is characterized by a high incidence of metastasis and poor survival.As epithelial–mesenchymal transition(EMT)is well recognized as a major factor initiating tumor metastasis,developi...
关键词：non-small cell lung cancer METASTASIS migration INVASION TRIPTOLIDE epithelial–mesenchymal transition β-catenin 
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