CHOLANGIOCYTE

作品数：20被引量：93H指数：6
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相关领域：医药卫生更多>>
相关作者：季维智金立方纪少珲杨纪峰更多>>
相关机构：绍兴文理学院中国科学院温州医学院更多>>
相关期刊：《World Journal of Gastrointestinal Pathophysiology》《Zoological Research》《Chinese Herbal Medicines》《Chinese Journal of Natural Medicines》更多>>
相关基金：国家自然科学基金更多>>
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A cholangiocyte organoid system for Cryptosporidium parvum cultivation and transcriptomic studies of biliary cryptosporidiosis被引量：1
《hLife》2024年第7期360-370,共11页Miner Deng Qing Tian Xinjie Mao Jie Zhang Yanting Wei Na Li Yaqiong Guo Lihua Xiao Yaoyu Feng 
supported by National Natural Science Foundation of China(32030109);111 Project(D20008);Double First-class Discipline Promotion Project(2023B10564003);supported by National Natural Science Foundation of China(U21A20258);supported by Natural Science Foundation of Guangzhou City(202201010140)。
Biliary cryptosporidiosis caused by Cryptosporidium is life-threatening in immunocompromised individuals,particularly those with acquired immune deficiency syndrome(AIDS),resulting in AIDS cholangiopathy.However,studi...
关键词：CRYPTOSPORIDIUM ORGANOIDS CHOLANGIOCYTE culture system host-pathogen interactions 
Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2^(-/-)Mice and Human Intrahepatic Cholangiocyte Organoid Models
《Research》2024年第2期355-372,共18页Qigu Yao Wenyi Chen Yingduo Yu Feiqiong Gao Jiahang Zhou Jian Wu Qiaoling Pan Jinfeng Yang Lingling Zhou Jiong Yu Hongcui Cao Lanjuan Li 
supported by the National Key Research and Development Program of China(No.2020YFA0113003);the Key Research and Development Project of Zhejiang Province(No.2023C03046);the Fundamental Research Funds for the Central Universities(No.2022ZFJH003);the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(Nos.JNL-2022026C and JNL-2023003C).
Primary sclerosing cholangitis(PSC)is a biliary disease accompanied by chronic inflammation of the liver and biliary stricture.Mesenchymal stem cells(MSCs)are used to treat liver diseases because of their immune regul...
关键词：INFLAMMATION TGR5 HUMAN 
Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation
《Journal of Integrative Medicine》2024年第2期188-198,共11页Meng Li Yang Zhou Hui Zhu Lie-ming Xu Jian Ping 
supported by grants from the National Natural Science Foundation of China(No.81773980);Project of Science and Technology Commission of Shanghai Municipality(No.15401902600)。
Objective:This study explores the mechanism of action of Danhongqing formula(DHQ),a compoundbased Chinese medicine formula,in the treatment of cholestatic liver fibrosis.Methods:In vivo experiments were conducted usin...
关键词：Liver cirrhosis BILIARY Long non-coding RNA H19 Danhongqing formula CHOLANGIOCYTE Hepatic stellate cells STAT3 transcription factor 
Sequence of events leading to primary biliary cholangitis被引量：1
《World Journal of Gastroenterology》2023年第37期5305-5312,共8页Ilaria Lenci Paola Carnì Martina Milana Agreta Bicaj Alessandro Signorello Leonardo Baiocchi 
Primary biliary cholangitis(PBC)is a chronic cholestatic liver disease that is observed more frequently in middle-aged women.This disorder is considered an autoimmune disease,since liver injury is sustained by the pre...
关键词：Primary biliary cholangitis CHOLANGIOCYTE Biliary secretion Biliary proliferation Ductular reaction Antimitochondrial antibody Cellular senescence Liver fibrosis 
Chuanxiong Rhizoma extracts prevent cholestatic liver injury by targeting H3K9ac-mediated and cholangiocyte-derived secretory protein PAI-1 and FN
《Chinese Journal of Natural Medicines》2023年第9期694-709,共16页LI Yajing MA Zhi DING Mingning JIA Kexin XU Bing ZHOU Fei LUO Ranyi XUE Xiaoyong WU Ruiyu GAO Feng LI Xiaojiaoyang 
the Beijing Municipal Science&Technology Commission(No.7212174);the National High-Level Talents Special Support Program to XL,the National Natural Science Foundation of China(Nos.82274186 and 82004045);National Key Research and Development Program on Modernization of Traditional Chinese Medicine(No.2022YFC-3502100);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202006).
Chuanxiong Rhizoma(CX,the dried rhizome of Ligusticum wallichii Franch.),a well-known traditional Chinese medicine,is clinically used for treating cardiovascular,cerebrovascular and hepatobiliary diseases.Cholestatic ...
关键词：Chuanxiong Rhizoma Cholestatic liver injury Ductular reaction CHOLANGIOCYTES Hepatic stellate cell 
Generation and metabolomic characterization of functional ductal organoids with biliary tree networks in decellularized liver scaffolds被引量：1
《Bioactive Materials》2023年第8期452-464,共13页Jiaxian Chen Shiwen Ma Hui Yang Xi Liang Heng Yao Beibei Guo Deying Chen Jing Jiang Dongyan Shi Jiaojiao Xin Keke Ren Xingping Zhou Yun Li Lei Geng Jun Li 
supported by the National Key R&D Program of China(2022YFA1104102,2022YFA1104603,2022YFC2304801);the National Natural Science Foundation of China(81830073,82272426);the National Provincial special support program for high-level personnel recruitment(Ten-thousand Talents Program,2018RA4016);Zhejiang Public Welfare Project(LY21H030007,LGF21H200006).
Developing functional ductal organoids(FDOs)is essential for liver regenerative medicine.We aimed to construct FDOs with biliary tree networks in rat decellularized liver scaffolds(DLSs)with primary cholangiocytes iso...
关键词：CHOLANGIOCYTE Decellularized scaffold Ductal organoid Extracellular matrix 
To explore the mechanism of Dahuang Lingxian Formula in relieving inflammatory response of bile duct cells based on IL-6/JAK/STAT3 signaling pathway
《Journal of Hainan Medical University》2023年第10期8-16,共9页PANG Jiao-an Yu Yuan CHEN Wei-tang YANG Wen LIU Chun-li XIAO Li-jun TENGJin-hao YE Gui-yuan LI Chen-ji GAN Yi-rong 
Guangxi Natural Science Foundation(No.2020GXNSFAA238012);Research on Traditional Chinese Medicine Prevention and Treatment of Liver and Bile Related Diseases in the 2021"Qihuang Project"High Level Talent Team Cultivation Project(No.2021006);2020 Guangxi University of Traditional Chinese Medicine First Affiliated Hospital Hospital Hospital Level Doctoral Initiation Fund Project(No.2020BS004);2020 Guangxi University of Traditional Chinese Medicine Introduction Doctoral Research Initiation Fund Project(No.2020BS030)。
Objective:To explore the mechanism of action of Dahuang Lingxian Formula in alleviating the inflammatory response of bile duct cells in LPS-induced intrahepatic bile duct inflammation model rats based on IL-6/JAK/STAT...
关键词：Dahuang Lingxian formula Cholangiocyte inflammation HEPATOLITHIASIS IL-6/JAK/STAT3 signaling pathway 
Integrating systematic pharmacology-based strategy and experimental validation to explore mechanism of Tripterygium glycoside on cholangiocyte-related liver injury被引量：6
《Chinese Herbal Medicines》2022年第4期563-575,共13页Yajing Li Sen Li Xiaoyong Xue Ting Wang Xiaojiaoyang Li 
supported by grants from Beijing Nova Program of Science&Technology(Grant No.Z191100001119088 to XL);Beijing Municipal Science&Technology Commission(Grant No.7212174 to XL);National Natural Science Foundation of China(Grant No.82004045 to XL);Young Talents Promotion Project of China Association of Traditional Chinese Medicine(Grant No.2020-QNRC2-01 to XL);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.ZYYCXTD-C-202006 to XL)。
Objective:Tripterygium glycoside(TG)is widely used in clinical practice for its multiple bioactivities including anti-inflammatory and immunosuppressive effects.However,emerging studies have frequently reported TG-ind...
关键词：cell apoptosis CHOLANGIOCYTE liver injury Tripterygium glycoside TRIPTOLIDE 
Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids被引量：37
《Protein & Cell》2020年第10期771-775,共5页
Dear Editor,The emerging pandemic of coronavirus,SARS-CoV-2(pre-viously named 2019-nCoV),has posed significant threats to global public health(Wu et al,2020).The dominant symp-toms of coronavirus disease 2019(COVID-19...
关键词：DAMAGE al. liver 
Hepatic senescence, the good and the bad被引量：8
《World Journal of Gastroenterology》2019年第34期5069-5081,共13页Nazmul Huda Gang Liu Honghai Hong Shengmin Yan Bilon Khambu Xiao-Ming Yin 
Gradual alterations of cell’s physiology and functions due to age or exposure to various stresses lead to the conversion of normal cells to senescent cells.Once becoming senescent,the cell stops dividing permanently ...
关键词：SENESCENCE SENESCENCE associated SECRETORY phenotype Hepatocyte CHOLANGIOCYTE HEPATIC stellate CELL CELL cycle ARREST DNA damage 
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