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Metabolome and RNA-seq reveal discrepant metabolism and secretory metabolism profile in skeletal muscle between obese and lean pigs at different ages
《Science China(Life Sciences)》2025年第4期1102-1117,共16页Liu Guo Junfei Xu Wenyue Zhou Sisi Chen Hanjing Shi Mengmeng Han Zekun Yang Yehui Duan Weijun Pang Yulong Yin Fengna Li 
supported by the National Natural Science Foundation of China(31972582);the STI 2030-Major Project(2023ZD04072);the Major Project of Changsha City(kh2401015);the Science and Technology Innovation Program of Hunan Province(2021RC4039);the Key Research and Development Program of Hunan Province(2022NK2026);the Youth Innovation Promotion Association CAS(Y202079);China Agriculture Research System of MOF and MARA(CARS-35)。
Metabolites and metabolism-related gene expression profiles in skeletal muscle change dramatically under obesity,aging and metabolic disease.Since obese and lean pigs are ideal models for metabolic research.Here,we co...
关键词：skeletal muscle METABOLOME transcriptome biomarker metabolite intercellular communication lipid deposition pig model 
Ribosome profiling and single-cell RNA sequencing identify the unfolded protein response as a key regulator of pigeon lactation
《Zoological Research》2025年第1期54-74,共21页Jing Liu San-Feng Liu Hui-Rong Mao Hong-Xia Jiang Shui-Bing Liu Xiao-Fei Xu Jin-Tao Wu Xun Liu Wen-Tao Zhang Xiao-Long Hu Biao Chen 
supported by the Department of Agriculture and Rural Affairs of Jiangxi Province,China (JXARS-09);Science and Technology Program of Guangdong Province,China (2020B1212060060)。
Pigeons and certain other avian species produce a milklike secretion in their crop sacs to nourish offspring,yet the detailed processes involved are not fully elucidated.This study investigated the crop sacs of 225-da...
关键词：PIGEON Crop lactation Secretory epithelial cells Single-cell RNA sequencing Ribosome profiling Signaling pathway 
Jiedu recipe,a compound Chinese herbal medicine,suppresses hepatocellular carcinoma metastasis by inhibiting the release of tumor-derived exosomes in a hypoxic microenvironment
《Journal of Integrative Medicine》2024年第6期696-708,共13页Wen-tao Jia Shuang Xiang Jin-bo Zhang Jia-ying Yuan Yu-qian Wang Shu-fang Liang Wan-fu Lin Xiao-feng Zhai Yan Shang Chang-quan Ling Bin-bin Cheng 
supported by the grants from National Natural Science Foundation of China(No.82030117,82074203,82170033,and 82374540);Special Fund for Research on Community Medicine and Health Management in Shanghai(No.2023SQ01);Medical Research Project of Health Commission of Shanghai Hongkou District(No.HW2302-43);Special Medical Basic Research Project of the First Affiliated Hospital of Naval Medical University(No.2021JCMS12);Wild Goose Array Project of Zhengzhou Center of Chinese People’s Liberation Army Joint Logistic Support Force。
Objective:Tumor-derived exosomes(TDEs)play crucial roles in intercellular communication.Hypoxia in the tumor microenvironment enhances secretion of TDEs and accelerates tumor metastasis.Jiedu recipe(JR),a traditional ...
关键词：Hypoxia Jiedu recipe Tumor-derived exosomes Premetastatic niches Secretory autophagy Quercetin 
Effects of Honeysuckle Chlorogenic Acid on Secretory Enzymes,Lipoxygenase A4,and Biochemical Indicators inModel Mice with Aluminum Induced Alzheimer's Disease
《Medicinal Plant》2024年第5期35-38,43,共5页Jialing HUANG Cuijuan HUANG Xiaomian TANG Weiming ZHOU Hanchao FENG Cuiping WEI Oufei HUANG Haipeng ZHANG Song NONG Shuqiu ZHANG Fuyu PAN 
Supported by Baise Science Research and Technology Development Plan Project(20232022);Cuangxi College Students’Innovation and Entrepreneurship Training Program(Recommend National Level2022210599040S).
[Objectives]To explore the effects of chlorogenic acid from honeysuckle on the secretion enzymes,lipoxygenase A4(LXA4),and blood biochemical indicators in mice with aluminum induced Alzheimer's disease(AD).[Methods]Ch...
关键词：Alzheimer's disease Chlorogenic acid SECRETASE Lipoxygenase A4 
Microglial senescence in neurodegeneration:Insights,implications,and therapeutic opportunities
《Neuroprotection》2024年第3期182-195,共14页Tobiloba Samuel Olajide Toheeb O.Oyerinde Omolabake I.Omotosho Oritoke M.Okeowo Olayemi J.Olajide Omamuyouwi M.Ijomone 
NIH-FIC,Grant/Award Number:K43TW011920。
The existing literature on neurodegenerative diseases(NDDs)reveals a common pathological feature:the accumulation of misfolded proteins.However,the heterogeneity in disease onset mechanisms and the specific brain regi...
关键词：aging FERRITIN microglia neurodegenerative diseases senescence-associated secretory phenotype senescent 
Unveiling mechanisms of lung aging in COPD: A promising target for therapeutics development
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第3期133-141,共9页Justine V.Devulder 
Chronic obstructive pulmonary disease(COPD)is a chronic inflammatory lung disease characterized by airflow limitation and changes in airway structures that can lead to chronic bronchitis,small airway diseases,and emph...
关键词：Chronic obstructive pulmonary disease Aging Cellular senescence Senescence-associated secretory phenotype MICRORNAS 
The actin motor protein OsMYA1 associates with OsExo70H1 and contributes to rice secretory defense by modulating OsSyp121 distribution
《Journal of Integrative Plant Biology》2024年第9期2058-2075,共18页Yuan‐Bao Li Chengyu Liu Ningning Shen Shuai Zhu Xianya Deng Zixuan Liu Li‐Bo Han Dingzhong Tang 
funded by the National Key Research and Development Program of China (2022YFF1001500);the National Natural Science Foundation of China (grant numbers 31970284,31900385);the Natural Science Foundation of Fujian Province,China (2023J01483, 2022J01616);the Distinguished Young Scientists Fund of Fujian Agriculture and Forestry University of China (xjq202121);the Fujian Provincial Science and Technology Key Project (2022NZ030014)
Magnaporthe oryzae(M.oryzae)is a devastating hemibiotrophic pathogen.Its biotrophic invasive hyphae(IH)are enclosed in the extrainvasive hyphal membrane produced by plant cells,thus generating a front line of the batt...
关键词：CYTOSKELETON plant defense mechanism rice blast vesicle delivery 
Individualized Traditional Chinese Medicine treatment vs antibiotics for recurrent urinary tract infections: a multicenter, randomized controlled study
《Journal of Traditional Chinese Medicine》2024年第3期524-529,共6页GU Xiangchen QIU Meisi XIE Lin CHEN Min DENG Yueyi ZHANG Changming JIAN Guihua WANG Chen WANG Yi 
TCM Guidance Project of Shanghai Science and Technology Commission:Study on TCM Syndrome Differentiation and Treatment Scheme for Chronic Urinary Tract Infection (No. 13401904600)。
OBJECTIVE: To systematically assess the effects of individualized Chinese medicines on recurrent urinary tract infections(rUTIs).METHODS: This study recruited 230 adult female patients in the remission phase of rUTIs ...
关键词：urinary tract infections MEDICINE Chinese traditional syndrome differentiation quality of life immunoglobulin A SECRETORY randomized controlled trial 
A case of secretory breast carcinoma with ETV6-NTRK3 fusion gene during childhood
《镜湖医学》2024年第1期62-63,F0004,共3页TAI Wai Meng CHAN Kin Iong WONG Peng Hong XU De Li WEN Jian Ming 
Secretory carcinoma is a rare breast cancer.We report a case of secretory carcinoma occurred in childhood.A 7-year-old girl had a history of a mass in the breast for 4 years.The tumor grew slowly and well circumscribe...
关键词：DIAGNOSIS CARCINOMA LESIONS 
Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer被引量：1
《Oncology Research》2024年第5期943-953,共11页JIANBO ZHOU FENG WAN BIN XIAO XIN LI CHENG PENG FU PENG 
funded by the National Natural Science Foundation of China(82003879);Project of Science and Technology Department of Sichuan Province(2023NSFSC1928,2023NSFSC1992);Young Elite Scientists Sponsorship Program China Association for Science and Technology(CACM-2020-QNRC1-01);Project of State Administration of Traditional Chinese Medicine of China(ZYYCXTD-D-202209);Project of Undergraduate Training Programs for Innovation and Entrepreneurship(S202310610637);the Open Research Fund of State Key Laboratory of Southwestern Chinese Medicine Resources(SKLTCM202205).
Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men,respectively,worldwide.Although the antitumor activity of chalcones has been extensively studied,the m...
关键词：Metochalcone Breast cancer Lung cancer SASP JAK2/STAT3 
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