云南高校图书馆联盟文献共享服务平台- CO-DELIVERY

CO-DELIVERY: 作品数：90被引量：226H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：吕立林珈好王秀丽何亮颖曹唯仪更多>>; 相关机构：中山大学孙逸仙纪念医院中国药科大学北京中医药大学北京大学更多>>; 相关期刊：《Signal Transduction and Targeted Therapy》《Chemical Research in Chinese Universities》《Science China Materials》《Journal of Materials Science & Technology》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>

Self-assembled co-delivery system of gold nanoparticles and paclitaxel based on in-situ dynamic covalent chemistry for synergistic chemo-photothermal therapy: 《Rare Metals》2025年第1期417-429,共13页Xiao-Xia Wu Ding-Hu Zhang Yi-Nan Ding Fei Cao Yang Li Jun-Lie Yao Xin-Yu Miao Lu-Lu He Jun Luo Jian-Wei Li Jie Lin Ai-Guo Wu Jia-Ping Zheng; supported by the National Natural Science Foundation of China(Nos.82202274,82072032,22161016,32025021,12374390,52002380 and 31971292),the National Science and Technology Major Project(No.2023ZD0500902);the Fellowship of China Postdoctoral Science Foundation(No.2023M743559);the Member of Youth Innovation Promotion Association Foundation of CAS,China(No.2023310);the Key Scientific and Technological Special Project of Ningbo City(No.2023Z209);the Natural Science Foundation of Zhejiang Province(No.LQ23H180003)。; Recently,stimuli-responsive nanocarriers capable of precision drug release have garnered significant attention in the field of drug delivery.Here,an in-situ dynamic covalent self-assembled(DCS)strategy was utilized to...; 关键词：in-situ dynamic covalent self-assembly(DCS) Disulfide macrocycles Host-guest interaction Glutathione(GSH)stimuli-response Chemo-photothermal therapy

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment: 《Nano Research》2025年第1期607-617,共11页Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han; supported by the National Key Research and Development Program of China(No.2022YFE0107800);National Natural Science Foundation of China(Nos.82373206,and 82073332);Zhejiang Provincial Natural Science Foundation of China(No.LHDMZ24H300002)。; Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drug...; 关键词：zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) DOXORUBICIN

Development of a multi-level pH-responsive lipid nanoplatform for efficient co-delivery of si RNA and small-molecule drugs in tumor treatment: 《Chinese Chemical Letters》2024年第12期265-272,共8页Yunjie Dang Yanru Feng Xiao Chen Chaoxing He Shujie Wei Dingyang Liu Jinlong Qi Huaxing Zhang Shaokun Yang Zhiyun Niu Bai Xiang; supported by the grants from the National Natural Science Foundation of China(Nos.81973251 and 81302725);Hebei Province Funding Project for Introduced Overseas Personnel(Nos.C20230351 and C20220345);Key Research and Development Program of Hebei Province(No.22372701D);Hebei Province Natural Science Fund(No.H2020206610);Hebei Provincial Health Commission Government-Funded Clinical Medicine Talent Program(No.ZF2024048);Hebei Medical University Undergraduate Innovative Experiment Program(No.USIP2023008)。; The combination of nucleic acid and small-molecule drugs in tumor treatment holds significant promise;however,the precise delivery and controlled release of drugs within the cytoplasm encounter substantial obstacles,i...; 关键词：Cyclic peptides siRNA Liposomal platform Multi-level pH-responsive CO-DELIVERY

Remodeling tumor microenvironment using pH-sensitive biomimetic co-delivery of TRAIL/R848 liposomes against colorectal cancer: 《Oncology Research》2024年第11期1765-1776,共12页YONGJIAN HUANG JINZHOU WANG JIUHUA XU NING RUAN; approved by the Institutional Animal Care and Use Committee(IACUC)of the First Affiliated Hospital of Fujian Medical University(No.2023048).; Background:Despite significant advancements in the development of anticancer therapies over the past few decades,the clinical management of colorectal cancer remains a challenging task.This study aims to investigate t...; 关键词：Colorectal cancer Plasmid TRAIL(pTRAIL) R848 Tumor-associated macrophages

Cocrystal@protein-anchoring nanococktail for combinatorially treating multidrug-resistant cancer: 《Acta Pharmaceutica Sinica B》2024年第10期4509-4525,共17页Jiahui Zou Xuyang Xing Chao Teng Qingling Zhao Wei He Xuri Wu Yuanzheng Xia; supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002,China);the Shanghai Science and Technology Committee(No.19430741500,China);National Key Research and Development Program of China(2018YFA0902000,China);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine(zdsys-202103,China).; Multidrug resistance(MDR),the major mechanism by which various cancers develop specific resistance to therapeutic agents,has set up enormous obstacles to many forms of tumor chemotherapy.Traditional cocktail therapy a...; 关键词：COCKTAIL MULTIDRUG-RESISTANT Co-delivery combined therapy Cytochrome C NANOCRYSTALS

A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids:Application to endogenous regeneration of articular cartilage: 《Bioactive Materials》2024年第10期634-648,共15页Liwei Fu Jiang Wu Pinxue Li Yazhe Zheng Zhichao Zhang Xun Yuan Zhengang Ding Chao Ning Xiang Sui Shuyun Liu Sirong Shi Quanyi Guo Yunfeng Lin; supported by the Natural Science Foundation of Beijing Municipality(L234024)。; Articular cartilage injury(ACI)remains one of the key challenges in regenerative medicine,as current treatment strategies do not result in ideal regeneration of hyaline-like cartilage.Enhancing endogenous repair via m...; 关键词：Tetrahedral framework nucleic acids miRNAs co-delivery Targeting system Articular cartilage endogenous regeneration Mesenchymal stem cells

Remote-controlled dexamethasone-duration on eye-surface with a micelle-magnetic nanoparticulate co-delivery system for dry eye disease: 《Acta Pharmaceutica Sinica B》2024年第8期3730-3745,共16页Qinxiang Zheng Chaoxiang Ge Kexin Li Longxin Wang Xiaoyu Xia Xiao Liu Rashid Mehmood Jianliang Shen Kaihui Nan Wei Chen Sen Lin; supported by National Natural Science Foundation of China(No.82070932);the Zhejiang Provincial Natural Science Foundation of China(No.LY19H120002);the internal funding of Wenzhou Medical University(No.KYYW202020,China);The Project of Wenzhou Medical University Affiliated Eye Hospital(No.YNZD2201901,China);the integration project of State Key Laboratory of Ophthalmology,Optometry and Vision Science(No.J02-20190202,China).; Dexamethasone(DEX)is used to treat ocular surface diseases.However,regulating DEX duration in tears while preventing its absorption into the anterior chamber is critical for balancing its therapy effects and the side ...; 关键词：Magnetic nanoparticle MICELLE DEXAMETHASONE Eye drop BIOAVAILABILITY Dry eye disease CORNEA CONJUNCTIVA

Co-delivery of retinoic acid and miRNA by functional Au nanoparticles for improved survival and CT imaging tracking of MSCs in pulmonary fibrosis therapy: 《Asian Journal of Pharmaceutical Sciences》2024年第4期159-174,共16页Xiaodi Li Shengnan Cheng Chenggong Yu Yuxuan Li Xiaoling Cao Yuhan Wang Zhijun Zhang Jie Huang; supported by the National Natural Science Foundation of China(Grant No.32171367);Natural Science Foundation of Jiangsu Province(Grant No.BK20230236);Science and Technology Project of Suzhou(Grant No.SS202135);CAS-VPST Silk Road Science Fund 2021(Grant No.121E32KYSB20200021).; Mesenchymal stem cells(MSCs)have emerged as promising candidates for idiopathic pulmonary fibrosis(IPF)therapy.Increasing the MSC survival rate and deepening the understanding of the behavior of transplanted MSCs are ...; 关键词：CT imaging tracking Gold nanoparticles Idiopathic pulmonary fibrosis Mesenchymal stem cells Drug delivery

Co-delivery of rhBMP-2 and zoledronic acid using calcium sulfate/hydroxyapatite carrier as a bioactive bone substitute to enhance and accelerate spinal fusion: 《Bioactive Materials》2024年第6期256-271,共16页Xinggui Tian Corina Vater Deepak Bushan Raina Lisa Findeisen Lucas-Maximilian Matuszewski Magnus Tägil Lars Lidgren Anja Winkler Robert Gottwald Niels Modler Klaus-Dieter Schaser Alexander C.Disch Stefan Zwingenberger; L.L.thanks the Olav Thon Foundation(Grant Number:21-90)for financial support;D.B.R.thanks Maggie-Stephens Foundation(Grant Number:20202004);Sten K Johnson Foundation(Grant Number:2021-0592);The Crafoord Foundation(2021-0550)for research grants.; Recombinant human bone morphogenetic protein-2(rhBMP-2)has been FDA-approved for lumbar fusion,but supraphysiologic initial burst release due to suboptimal carrier and late excess bone resorption caused by osteoclast ...; 关键词：Calcium sulfate/hydroxyapatite Bone morphogenetic protein 2 BISPHOSPHONATE Spinal fusion Bone substitute

Immunotherapeutic hydrogel for co-delivery of STAT3 siRNA liposomes and lidocaine hydrochloride for postoperative comprehensive management of NSCLC in a single application: 《Asian Journal of Pharmaceutical Sciences》2024年第3期115-130,共16页Xianglei Fu Yanbin Shi Zili Gu Hengchang Zang Lian Li Qingjie Wang Yongjun Wang Xiaogang Zhao Hang Wu Shengnan Qiu Yankun Zhang Jiamin Zhou Xiangqin Chen Hua Shen Guimei Lin; supported by the National Natural Science Foundation of China[grant numbers 21873057,22373059];the Natural Science Foundation of Shandong Province[grant numbers ZR2023MB082]。; Despite standard treatment for non-small cell lung cancer(NSCLC)being surgical resection,cancer recurrence and complications,such as induction of malignant pleural effusion(MPE)and significant postoperative pain,usual...; 关键词：LIPOSOME HYDROGEL Signal transducer and activator of transcription 3 Non-small cell lung cancer MACROPHAGE

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