BISPHOSPHONATE

作品数：47被引量：98H指数：5
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相关领域：医药卫生更多>>
相关作者：黄兆波赵凤东范顺武万双林更多>>
相关机构：重庆市中山医院浙江大学医学院附属邵逸夫医院天津医科大学四川大学更多>>
相关期刊：《Journal of Wuhan University of Technology(Materials Science)》《Acta Pharmacologica Sinica》《日本医学介绍》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金更多>>
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Prevalence of Osteonecrosis of the Jaw (ONJ) in Patients Exposed to Bisphosphonates at a University Hospital in Marrakech
《Open Journal of Epidemiology》2025年第1期65-75,共11页Aicha Oubbaih Mouad Mouhtaram Youness Moutaabid Bouchra Badre Samira Bellemkhannate Nadia Zaim 
Background: Bisphosphonates are compounds similar to inorganic pyrophosphates, with anti-angiogenic, anti-inflammatory, anti-bone resorption, and antitumor effects. They are used to prevent bone metastases in cancer a...
关键词：Bisphosphonate-Related Osteonecrosis of the Jaw BISPHOSPHONATES Osteonecrosis of the Jaw PREVALENCE 
Prevalence and Risk Factors of Osteonecrosis of the Jaw in Patients with Bisphosphonate Exposure in Casablanca, Morocco: An Observational Study
《Open Journal of Epidemiology》2024年第3期533-545,共13页Aicha Oubbaih Soukaina Remch Meryem Reggab Bouchra Badre Samira Bellemkhannate Nadia Zaim 
Objective: To study the prevalence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and to determine the risk factors associated with the occurrence of this pathology. Method: An observational retrospective ...
关键词：Bisphosphonate-Related Osteonecrosis of the Jaw BISPHOSPHONATES Osteonecrosis of the Jaw PREVALENCE 
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
《Bone Research》2024年第3期734-744,共11页Zhenqiang Yao Akram Ayoub Venkatesan Srinivasan Jun Wu Churou Tang Rong Duan Aleksa Milosavljevic Lianping Xing Frank H.Ebetino Alison J.Frontier Brendan F.Boyce 
funded by National Institutes of Health,National Institute on Aging,grant numbers,R01AG076731,R01AG049994;National Institute for Arthritis and Musculoskeletal and Skin Diseases,R01AR043510,and P30 AR069655。
Osteoporosis remains incurable.The most widely used antiresorptive agents,bisphosphonates(BPs),also inhibit bone formation,while the anabolic agent,teriparatide,does not inhibit bone resorption,and thus they have limi...
关键词：res CONJUGATE phosphonate 
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs
《International Journal of Oral Science》2024年第3期528-538,共11页Yizhou Jin Xiao Han Yuejun Wang Zhipeng Fan 
supported by grants from the National Natural Science Foundation of China(82130028 to Z.P.F.);National Key Research and Development Program(2022YFA1104401);CAMS Innovation Fund for Medical Sciences(2019-I2M-5-031 to Z.P.F.);grants from Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(NO.CXTD202204 to Z.P.F.).
Bisphosphonate-related osteonecrosis of jaw(BRONJ)is characterized by impaired osteogenic differentiation of orofacial bone marrow stromal cells(BMSCs).Corin has recently been demonstrated to act as a key regulator in...
关键词：IMPAIRED cor mediated 
Impact and mechanism of bisphosphonate depressant 1-hydroxypropane-1,1-diphosphonic acid on flotation decalcification of dolomite-rich magnesite ore
《International Journal of Mining Science and Technology》2024年第7期1017-1032,共16页Wengang Liu Xudong Chen Wenbao Liu Naixu Zhang Yong Mao Ying Guo 
supported by the Fundamental Research Funds for the Central Universities(No.N2201005).
Given the depletion of high-quality magnesite deposits and the rising demand for high-end magnesium materials,the separation and utilization of high-calcium magnesite ores have become essential.However,the similar sur...
关键词：Depressant Interfacial mechanism MAGNESITE DOLOMITE DFT DECALCIFICATION 
Mazabraud’s syndrome in female patients:Two case reports
《World Journal of Orthopedics》2024年第6期593-601,共9页Xiu-Mao Li Ze-Hao Chen Ke-Yi Wang Jun-Nan Chen Zhao-Nong Yao Yu-Hong Yao Xiao-Wei Zhou Nong Lin 
Supported by National Natural Science Foundation of China,No.81702662.
BACKGROUND Mazabraud’s syndrome(MS)is a rare and slowly progressive benign disease characterized by the concurrent presence of fibrous dysplasia of bone and intramuscular myxoma,and is thought to be associated with m...
关键词：Mazabraud's syndrome Fibrous dysplasia Intramuscular myxoma BISPHOSPHONATE Case report 
Co-delivery of rhBMP-2 and zoledronic acid using calcium sulfate/hydroxyapatite carrier as a bioactive bone substitute to enhance and accelerate spinal fusion
《Bioactive Materials》2024年第6期256-271,共16页Xinggui Tian Corina Vater Deepak Bushan Raina Lisa Findeisen Lucas-Maximilian Matuszewski Magnus Tägil Lars Lidgren Anja Winkler Robert Gottwald Niels Modler Klaus-Dieter Schaser Alexander C.Disch Stefan Zwingenberger 
L.L.thanks the Olav Thon Foundation(Grant Number:21-90)for financial support;D.B.R.thanks Maggie-Stephens Foundation(Grant Number:20202004);Sten K Johnson Foundation(Grant Number:2021-0592);The Crafoord Foundation(2021-0550)for research grants.
Recombinant human bone morphogenetic protein-2(rhBMP-2)has been FDA-approved for lumbar fusion,but supraphysiologic initial burst release due to suboptimal carrier and late excess bone resorption caused by osteoclast ...
关键词：Calcium sulfate/hydroxyapatite Bone morphogenetic protein 2 BISPHOSPHONATE Spinal fusion Bone substitute 
Impact of bisphosphonate treatment on bone mineral density after kidney transplant
《World Journal of Transplantation》2024年第3期102-109,共8页Georgia Andriana Georgopoulou Marios Papasotiriou Theodoros Ntrinias Eirini Savvidaki Dimitrios S Goumenos Evangelos Papachristou 
BACKGROUND Mineral bone disease is associated with chronic kidney disease and persists after kidney transplantation.Immunosuppressive treatment contributes to the patho-genesis of this disease.Bisphosphonate treatment...
关键词：Mineral and bone disorders Chronic kidney disease Kidney transplant recipients BISPHOSPHONATES Bone mineral density 
Boosting synergism of chemo- and immunotherapies via switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules被引量：1
《Acta Pharmaceutica Sinica B》2024年第2期836-853,共18页Ge Song Minghui Li Shumin Fan Mengmeng Qin Bin Shao Wenbing Dai Hua Zhang Xueqing Wang Bing He Qiang Zhang 
supported by National Key Research and Development Program (2022YFA1206100, China);Natural Science Foundation of Beijing Municipality (L212013, China);AI+Health Collaborative Innovation Cultivation Project (Z211100003521002,China);National Natural Science Foundation of China(82073786, 81872809, U20A20412, 81821004)
Conventional chemotherapy based on cytotoxic drugs is facing tough challenges recently following the advances of monoclonal antibodies and molecularly targeted drugs.It is critical to inspire new potential to remodel ...
关键词：Bisphosphonate coordinationlipid nanogranules Ferroptosis Mevalonatemetabolism Mitochondrial metabolism Nano-systematic biology 
Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S.aureus infection with osseointegration in murine models of implant-associated osteomyelitis被引量：3
《Bone Research》2023年第4期751-763,共13页Youliang Ren Jason Weeks Thomas Xue Joshua Rainbolt Karen L.de Mesy Bentley Ye Shu Yuting Liu Elysia Masters Philip Cherian Charles E.McKenna Jeffrey Neighbors Frank H.Ebetino Edward M.Schwarz Shuting Sun Chao Xie 
supported by grants from the National Institutes of Health(SBIR R44 AI125060,NIAMS P50 AR072000,and NIAMS P30 AR069655)。
Eradication of MRSA osteomyelitis requires elimination of distinct biofilms.To overcome this,we developed bisphosphonateconjugated sitafloxacin(BCS,BV600072)and hydroxybisphosphonate-conjugate sitafloxacin(HBCS,BV6307...
关键词：IMPLANT INFECTION overcome 
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