HALF-LIFE

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Systematic Analysis of Post-Translational Modifications for Increased Longevity of Biotherapeutic Proteins
《Computational Molecular Bioscience》2024年第3期125-145,共21页Justin Kim Karanveer Sadiora 
Protein-based therapeutics (PPTs) are drugs used to treat a variety of different conditions in the human body by alleviating enzymatic deficiencies, augmenting other proteins and drugs, modulating signal pathways, and...
关键词：Post-Translational Modification Protein-Based Therapeutics Therapeutic Half-Life Protein Aggregation Protein Reception 
Di-PEGylated insulin:A long-acting insulin conjugate with superior safety in reducing hypoglycemic events
《Acta Pharmaceutica Sinica B》2024年第6期2761-2772,共12页Zhipeng Zeng Runcheng Tan Shi Chen Haolin Chen Zhijia Liu Lixin Liu Mingqiang Li Yongming Chen 
supported by the National Natural Science Foundation of China(No.51820105004,China);the Key Areas Research and Development Program of Guangzhou(No.202007020006,China).
Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes,its therapeutic potential is compromised by its short half-life and narrow therapeutic index.Current long-acting insulin analogs...
关键词：Diabetes INSULIN Therapeutic index HYPOGLYCEMIA PEGYLATION Receptor-mediated clearance HALF-LIFE Diabetic nephropathy 
Experimental study on photodegradation and leaching of typical pesticides in greenhouse soil from Shouguang, Shandong Province, East China
《Ecological Processes》2024年第2期32-47,共16页Li‑Ting Hua Rui‑Lin Wu Cun‑Lu Li Chao‑Nan Wang Yi‑Long Li Fu‑Liu Xu 
funded by the National Key Research and Development Plan of China(2016YFD0201204);the National Natural Science Foundation of China–Shandong United Fund(U2006214)
Background Pesticide use contributes to national food security.The dissipation pathways and degradation mecha-nisms of pesticides have been widely studied and pesticide residues have remained a focus of public concern...
关键词：PESTICIDES PHOTODEGRADATION HALF-LIFE LEACHING Vertical migration 
Screened peptides from one-bead one-compound technique extend half-life of peptide drugs in circulation through binding to albumin
《Chinese Chemical Letters》2024年第3期384-388,共5页Yi-Jing Li Lingze Zhang Ming-Hao Pang Pei-Pei Yang Lu-Ming Guo Kuo Zhang Da-Yong Hou Lei Wang Hao Wang Hui Cao 
supported by National Natural Science Foundation of China(Nos.51890891,51890894,52073027,and 51773017);National Key R&D Program of China(No.2018YFE0205400);the Fundamental Research Funds for the Central Universities(No.FRFDF-19–001)。
Peptide drugs are known for their high biological safety.However,compared with small molecule drugs,peptide drugs are easily oxidized and hydrolyzed as well as short in half-life.Herein,inspired by the long circulatio...
关键词：One-bead one-compound Combinatorial library Albumin binding Drug delivery TRIPTORELIN 
ARHCS (Automatic Rainfall Half-Life Cluster System): A Landslides Early Warning System (LEWS) Using Cluster Analysis and Automatic Threshold Definition
《International Journal of Geosciences》2024年第1期54-69,共16页Cassiano Antonio Bortolozo Luana Albertani Pampuch Marcio Roberto Magalhães De Andrade Daniel Metodiev Adenilson Roberto Carvalho Tatiana Sussel Gonçalves Mendes Tristan Pryer Harideva Marturano Egas Rodolfo Moreda Mendes Isadora Araújo Sousa Jenny Power 
A significant portion of Landslide Early Warning Systems (LEWS) relies on the definition of operational thresholds and the monitoring of cumulative rainfall for alert issuance. These thresholds can be obtained in vari...
关键词：Landslides Early Warning System (LEWS) Cluster Analysis LANDSLIDES Brazil 
Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector
《Research》2023年第2期33-41,共9页Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou 
This project is supported in part by grants from the Ministry of Science and Technology of China(No.2016YFA0400301 and 2016YFA0400302);grants from National Science Foundation of China(Nos.12090061,12090062,12005131,11905128,and 11925502);by Office of Science and Technology,Shanghai Municipal Government(grant No.18JC1410200).
Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe u...
关键词：DECAY double DETERMINATION 
Progress on the CSRe Storage Ring Nuclear Physics Research: Mass and Half-life Measurements
《IMP & HIRFL Annual Report》2022年第1期44-45,共2页Yan Xinliang Wang Meng Zhang Yuhu CSR mass measurement collaboration 
CAS Young Scholar of Regional Development([2023]15);CAS Project for Young Scientists in Basic Research(YSBR-002);National Key R&D Program of China(2018YFA0404401);Strategic Priority Research Program of Chinese Academy of Sciences(XDB34000000);National Natural Science Foundation of China(12135017,12121005)。
Nuclear mass and half-life measurements are important research projects at the CSRe storage ring.The progress is summarized below.The data analyses are now nished for the 6th traditional IMS experiment with ^(112)Sn f...
关键词：RING summarized ANALYSES 
Determination of the half-life of^(184g)Re and the isomeric ratio of^(184m,g)Re induced by D-T neutrons
《Chinese Physics C》2022年第11期168-176,共9页Changlin Lan Yuting Wei Jiahao Wang Xianlin Yang Gong Jiang Yujie Ge Chao Xu Li Feng Xiaojun Li 
Supported by the National Natural Science Foundation of China(11975113)。
The isomeric ratio of^(184m,g)Re and the half-life of^(184g)Re were measured in the ^(185)Re(n,2n)^(184)Re reaction at 14.8 MeV,and the uncertainty was discussed in detail.The measurements were performed using the act...
关键词：HALF-LIFE ^(184)Re γ-ray spectrometry isomeric ratio 
Systematic study on α-decay half-lives of uranium isotopes with a screened electrostatic barrier
《Chinese Physics C》2022年第11期212-220,共9页Yang-Yang Xu De-Xing Zhu You-Tian Zou Xi-Jun Wu Biao He Xiao-Hua Li 
Supported in part by the National Natural Science Foundation of China(12175100,11975132);the Construct Program of the Key Discipline in Hunan Province;the Research Foundation of Education Bureau of Hunan Province,China(21B0402,18A237);the Natural Science Foundation of Hunan Province,China(2018JJ2321);the Innovation Group of Nuclear and Particle Physics in USC;the Shandong Province Natural Science Foundation,China(ZR2019YQ01);the Hunan Provincial Innovation Foundation For Postgraduate(CX20210942);the Opening Project of Cooperative Innovation Center for Nuclear Fuel Cycle Technology and Equipment,University of South China(2019KFZ10)。
In the present work,we systematically study the α-decay half-lives of uranium(Z=92) isotopes based on the Gamow model with a screened electrostatic barrier.There are only two adjustable parameters in our model i.e.th...
关键词：αdecay HALF-LIFE Gamow model screened electrostatic barrier 
Determination of the half-life of^(91)Sr in uranium sample bombarded by 14.8 MeV neutron
《Radiation Detection Technology and Methods》2022年第3期361-366,共6页Yuting Wei Changlin Lan Li Feng Chao Xu Xianlin Yang Xiaojun Li Jiahao Wang Yujie Ge Benchao Lou Li Jiang 
supported by the National Natural Science Foundation of China(Grant No.11975113).
Purpose Due to the few reports on the^(91)Sr half-life previously,the accuracy and uncertainty of the results are difficult to meet the requirements such as calculating the cross section and thefission yields of 235U,23...
关键词：HALF-LIFE 91Sr γ-ray spectrometry UNCERTAINTY 
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