Colorimetric and Photothermal Dual-modal Visual Detection of Iodide Ion Based on G-Quadruplex-Hemin Cascade Signal Amplification  

作　　者：CHEN Yanyue LIU Jiali LIU Jiawen HU Rong YANG Yunhui ZHANG Xiaobing 

机构地区：[1]College of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming,650500,P.R.China [2]Molecular Science and Biomedicine Laboratory,State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Collaborative Innovation Center for Molecular Engineering for Theronastics,Hunan University,Changsha,410082,P.R.China

出　　处：《Chemical Research in Chinese Universities》2024年第2期305-310,共6页高等学校化学研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21864026,21605130);the Natural Science Foundation of Yunnan Province,China(Nos.2018FB016,2016FD017).

摘　　要：The insufficient internal resorption of iodide ions(I−)leads to thyroid disorders,such as goiter,hypothyroidism,and cretinism in adults.In this paper,a portable point-of-care testing(POCT)platform was developed for the dual-modal analysis of I^(−),seamlessly integrating both colorimetric and photothermal thermometer techniques.The quantification of results was achieved using a standard thermometer or smartphone.G-Quadruplex/Hemin(G4/Hemin)is the DNAzyme with peroxidase-like activity.The catalytic efficacy of G-quadruplex structures can be enhanced with the help of I^(−),manifesting as multicolor transitions from colorless to green and then blue,and accompanied by the increase of temperature,which can be used for the quantitative detection of I^(−).Additionally,digital analysis according to the three-color channels(R/G/B)by a cellphone eliminated the requirement for intricate instruments.This dual-modal method for portable I^(−)determination is cost-effectiveness,simplicity,remarkable sensitivity(0.5 nmol/L)and selectivity.Besides,it was applied to determining the concentration of I^(−)in spiked serum samples.

关 键 词：Dual-modal platform G-QUADRUPLEX Iodide ion Point-of-care testing(POCT) APTASENSOR 

分 类 号：O657.3[理学—分析化学]