supported by the National Natural Science Foundation of China(82001424,82171176);the Key Program of the Natural Science Foundation of Zhejiang,China(LZ19H090003).
The incidence rate of anxiety and depression is significantly higher in patients with inflammatory bowel diseases(IBD)than in the general population.The mechanisms underlying dextran sulfate sodium(DSS)-induced depres...
supported by the Scientific and Technological Innovation 2030 Program of China(2021ZD0203003)。
High-fat diet(HFD)-induced obesity is a growing epidemic and major health concern.While excessive daytime sleepiness(EDS)is a common symptom of HFD-induced obesity,preliminary findings suggest that reduced wakefulness...
the Frontier Research Program of Biol and Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)(2018GZR110105006);the National Natural ScienceFoundation of China(31900735,82171492,and 81922024);the Science,Technology and Innovation Commission of Shenzhen Municipality(RCJC 20200714114556103 and ZDSYS20190902093601675).
Dear Editor,Alzheimer's disease(AD)is one of the most devastating neurodegenerative disorders and the most common form of dementia.Synaptic loss is a hallmark of AD pathology and exacerbates cognitive impairment[1].Sy...
partly supported by the National Major Project of China Science and Technology Innovation 2030 for Brain Science and BrainInspired Technology(Grant No.2021ZD0203400 to Z.-L.H.);the National Natural Science Foundation of China(Grant Nos.82020108014 and 32070984 to Z.-L.H.);the Shanghai Science and Technology Innovation Action Plan Laboratory Animal Research Project(Grant No.201409001800 to Z.-L.H.);Program for Shanghai Outstanding Academic Leaders(to Z.-L.H.);the Shanghai Municipal Science and Technology Major Project;ZJLab(Grant No.2018SHZDZX01 to Z-.L.H.)。
The paraventricular nucleus of the hypothalamus(PVH)acts as a cohesive functional unit that regulates neuroendocrine and autonomic function,complex behavior,and negative emotions after stress.However,how the PVH integ...
Neuropeptide S(NPS)is a neuromodulator that concentratively expressed in the Kolliker Fuse nucleus(KF)and pericoerulear area(Peri-LC)in mice.NPS and its receptor(NPSR)system participates multiple biological effects.Th...
This work was supported by the National Natural Science Foundation of China(31530091 and 81870912);the National Key Research and Development Program of China(2016YFC1306703);the Science and Technology Program of Guangdong Province,China(2018B030334001);the Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,China.
The paraventricular nucleus of the thalamus(PVT),which serves as a hub,receives dense projections from the medial prefrontal cortex(mPFC)and projects to the lateral division of central amygdala(CeL).The infralimbic(IL...
supported by the National Natural Science Foundation of China (81770426, 81600333, 81600330, and 81800373);China Postdoctoral Science Foundation (2016M602835);Shaanxi Postdoctoral Science Foundation (2016BSHEDZZ91).
Toll-like receptor 4 (TLR4) and cellular Src (cSrc) are closely associated with inflammatory cytokines and oxidative stress in hypertension, so we designed this study to explore the exact role of c-Src in the mechanis...
BACKGROUND Giant cavernous malformation(GCM)is rarely found in intraventricular or paraventricular locations.CASE SUMMARY We present two cases of 6-mo and 21-mo boys with intraventricular and paraventricular GCMs incl...
This work was supported by the grants from the National Natural Science Foundation of China(Nos.81771236 and 81501190);Joint Research Project of Pudong New Area Health and Family Planning Commission(No.PW2015D-3).
The hypothalamus-pituitary-adrenal(HPA)axis is known to mediate gut-brain interaction,and the pathological inflammatory process in the intestine can induce HPA axis involved'fight or flight response to suppress or fac...
supported by grants from the National Natural Science Foundation of China (81471347, 81771426, and 31500853);the Talent-Introducing Project of State Administration of Foreign Experts Affairs of China (X2017008)
The thalamus is the gate of the cerebral cortex, the ultimate target for the neural networks controlling behavioral states and cognitive functions. According to the reticular theory initially proposed by Moruzzi and M...