Structure and mechanism for DNA lesion recognition  

作　　者：Wei Yang 

机构地区：[1]Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA

出　　处：《Cell Research》2008年第1期184-197,共14页细胞研究（英文版）

摘　　要：A fundamental question in DNA repair is how a lesion is detected when embedded in millions to billions of normal base pairs. Extensive structural and functional studies reveal atomic details of DNA repair protein and nucleic acid interactions. This review summarizes seemingly diverse structural motifs used in lesion recognition and suggests a general mechanism to recognize DNA lesion by the poor base stacking. After initial recognition of this shared structural feature of lesions, different DNA repair pathways use unique verification mechanisms to ensure correct lesion identification and removal.

关 键 词：base unstacking MMR BER NER ATPASE NUCLEASE GLYCOSYLASE 

分 类 号：Q523[生物学—生物化学]