supported by the National Key Research and Development Program of China(2021YFA1301400);the National Natural Science Foundation of China(32370934);the Shanghai Jiao Tong University 2030 Initiative(2030-B23).
Antibody diversification is essential for an effective immune response,with somatic hypermutation(SHM)serving as a key molecular process in this adaptation.Activation-induced cytidine deaminase(AID)initiates SHM by in...