TRANSVERSION

作品数：3被引量：25H指数：2
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相关期刊：《Science China(Life Sciences)》《National Science Review》更多>>
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Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase被引量：11
《National Science Review》2023年第8期72-81,共10页Huawei Tong Nana Liu Yinghui Wei Yingsi Zhou Yun Li Danni Wu Ming Jin Shuna Cui Hengbin Li Guoling Li Jingxing Zhou Yuan Yuan Hainan Zhang Linyu Shi Xuan Yao Hui Yang 
This work was supported by HuidaGene Therapeutics Co.,Ltd.(H.T.).
Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine(C)or adenine(A),but no method for guanine(G)or thymine(T)editing is available at present.Here we developed a deaminase-f...
关键词：GLYCOSYLASE base excision repair base editor depurination deaminase-free TRANSVERSION 
Enrichment of AT-TA transversion at 5′-CAG-3′ motif is not a unique mutational signature of aristolochic acid
《Science China(Life Sciences)》2019年第7期974-977,共4页Xin Wang Xinming Qi Jin Ren 
supported by grants from the National Science and Technology Major Project(2018ZX09101002-002)
Aristolochic acids (AA) are the etiologic agents of aristolochic acid nephropathy (AAN) and contribute to the global prevalence of chronic kidney disease and urothelial cancer (Grollman et al.,2007).DNA adducts formed...
关键词：Aristolochic ACIDS mutational SIGNATURE and HEPATOCELLULAR carcinoma 
The study of neighboring nucleotide composition and transition/transversion bias被引量：14
《Science China(Life Sciences)》2006年第4期395-402,共8页ZHAO Hui LI Qizhai LI Jun ZENG Changqing HU Songnian YU Jun 
supported partly by the National 863 Project(Grant No.2003AA231050);National Natural Science Foundation of China(Grant No.10371126);Mega-projects of Science Research for the 10th Five-year Plan(Grant No.2002BA711A09).
Base substitution is one of the raw fuels that produce genetic variation; drive evolution. Recent studies have shown that the genome components affect mutation patterns to some extent. In order to infer the correlatio...
关键词：Base substitution SNP Transition bias TRANSITION TRANSVERSION 
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