Enrichment of AT-TA transversion at 5′-CAG-3′ motif is not a unique mutational signature of aristolochic acid  

作　　者：Xin Wang Xinming Qi Jin Ren 

机构地区：[1]Center for Drug Safety Evaluation and Research,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science China(Life Sciences)》2019年第7期974-977,共4页中国科学（生命科学英文版）

基　　金：supported by grants from the National Science and Technology Major Project(2018ZX09101002-002)

摘　　要：Aristolochic acids (AA) are the etiologic agents of aristolochic acid nephropathy (AAN) and contribute to the global prevalence of chronic kidney disease and urothelial cancer (Grollman et al.,2007).DNA adducts formed by AA generate a unique A>T transversions mutation spectrum at adenine exclusively on the non-transcribed strand (strand bias).

关 键 词：Aristolochic ACIDS mutational SIGNATURE and HEPATOCELLULAR carcinoma 

分 类 号：Q[生物学]