机构地区:[1]Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Hangzhou 310016 Zhejiang Province China [2]the First People’Hospital of Xiaoshan District,Hangzhou 311200,Zhejiang Province,China [3]Department of Gastroenterology,Internal Medicine,Virginia Commonwealth University,Richmond,VA 23298,United States
出 处:《World Journal of Gastroenterology》2010年第35期4476-4482,共7页世界胃肠病学杂志(英文版)
基 金:Supported by The grants from the Education Department of Zhejiang Province, China, No Y200803495;Zhejiang Provincial Administration of Traditional Chinese Medicine, China, No 2008CA058;Qianjiang Talent Project of Science and Technology, China, No 2008R10022
摘 要:AIM:To investigate the association between Ser326Cys human oxoguanine glycosylase 1(hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori(H.pylori) eradication.METHODS:A total of 488 subjects(73 patients with gastric cancer,160 with atrophic gastritis after H.pylori eradication and 255 controls) were prospectively collected.Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to distinguish hOGG1 Ser326Cys polymorphism.Statistical analysis was conducted by two-sample t test for continuous variables and χ2 test for categorical variables.Logistic regression models were used to f ind the risk factors for gastric cancer and atrophic gastritis.RESULTS:Neither the hOGG1 Ser/Cys nor the Cys/Cys genotype was associated with gastric cancer.Compared with the Ser/Ser genotype,odds ratio(OR) for Ser/Cys was 0.96,(95% CI:0.51-1.84) and OR for Cys/Cys was 1.1(95% CI:0.48-2.1).No association was detected between hOGG1 polymorphism and Lauren type of gastric cancer(P=0.61) either.However,Ser/Cys and Cys/Cys were signif icantly associated with atrophic gastritis with OR:1.76 for Ser/Cys(95% CI:1.03-3.0) and 2.38 for Cys/Cys(95% CI:1.34-4.23).After controlling for age,gender,smoking and alcohol,there were still signif icant associations with OR:2.05 for Ser/Cys(95% CI:1.14-3.68) and 2.76 for Cys/Cys(95% CI:1.47-5.18).CONCLUSION:HOGG1 polymorphisms(Cys/Cys and Ser/Cys) are associated with atrophic gastritis.No significant association is detected between hOGG1 polymorphisms(Cys/Cys or Ser/Cys) and gastric cancer.AIM:To investigate the association between Ser326Cys human oxoguanine glycosylase 1(hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori(H.pylori) eradication.METHODS:A total of 488 subjects(73 patients with gastric cancer,160 with atrophic gastritis after H.pylori eradication and 255 controls) were prospectively collected.Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to distinguish hOGG1 Ser326Cys polymorphism.Statistical analysis was conducted by two-sample t test for continuous variables and χ2 test for categorical variables.Logistic regression models were used to f ind the risk factors for gastric cancer and atrophic gastritis.RESULTS:Neither the hOGG1 Ser/Cys nor the Cys/Cys genotype was associated with gastric cancer.Compared with the Ser/Ser genotype,odds ratio(OR) for Ser/Cys was 0.96,(95% CI:0.51-1.84) and OR for Cys/Cys was 1.1(95% CI:0.48-2.1).No association was detected between hOGG1 polymorphism and Lauren type of gastric cancer(P=0.61) either.However,Ser/Cys and Cys/Cys were signif icantly associated with atrophic gastritis with OR:1.76 for Ser/Cys(95% CI:1.03-3.0) and 2.38 for Cys/Cys(95% CI:1.34-4.23).After controlling for age,gender,smoking and alcohol,there were still signif icant associations with OR:2.05 for Ser/Cys(95% CI:1.14-3.68) and 2.76 for Cys/Cys(95% CI:1.47-5.18).CONCLUSION:HOGG1 polymorphisms(Cys/Cys and Ser/Cys) are associated with atrophic gastritis.No significant association is detected between hOGG1 polymorphisms(Cys/Cys or Ser/Cys) and gastric cancer.
关 键 词:Human oxoguanine glycosylase 1 polymorphism Atrophic gastritis Gastric cancer
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