A novel strategy to protect prokaryotic cells from virus infection  

作　　者：Yoshizumi Ishino 

机构地区：[1]Department of Bioscience and Biotechnology,Graduate school of Bioresource and Bioenvironmental Sciences,Kyushu University,Fukuoka 819-0395,Japan [2]Cell Biology Center,Institute of Innovative Research,Tokyo Institute of Technology,Kanagawa 226-8503,Japan [3]Genome Editing Research Institute,Nagahama Institute of Bio-Science and Technology,Shiga 526-0829,Japan

出　　处：《Engineering Microbiology》2024年第2期104-106,共3页工程微生物学（英文）

摘　　要：The recent discovery of the CRISPR-Cas-mediated acquired immunity system highlights the fact that our knowl-edge of phage/virus defense mechanisms encoded in bacterial and archaeal genomes is far from complete.Indeed,new prokaryotic immune systems are now continually being discovered.A recent report described a novel glyco-sylase that recognizesα-glycosyl-hydroxymethyl cytosin(α-Glu-hmC),a modified base observed in the T4 phage genome,where it produces an abasic site,thereby inhibiting the phage propagation.

关 键 词：Prokaryotic immunity Antiviral defense GLYCOSYLASE Modified base Functional screening 

分 类 号：Q93[生物学—微生物学]