An overview of the functions and mechanisms of APOBEC3A in tumorigenesis  

作　　者：Yuqi Yang Nan Liu Likun Gong 

机构地区：[1]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第11期4637-4648,共12页药学学报（英文版）

基　　金：Shanghai Post-doctoral Excellence Program(No.2022689,China).

摘　　要：The APOBEC3(A3)family plays a pivotal role in the immune system by performing DNA/RNA single-strand deamination.Cancers mostly arise from the accumulation of chronic mutations in somatic cells,and recent research has highlighted the A3 family as a major contributor to tumor-associated mutations,with A3A being a key driver gene leading to cancer-related mutations.A3A helps to defend the host against virus-induced tumors by editing the genome of cancer-associated viruses that invade the host.However,when it is abnormally expressed,it leads to persistent,chronic mutations in the genome,thereby fueling tumorigenesis.Notably,A3A is prominently expressed in innate immune cells,particularly macrophages,thereby affecting the functional state of tumor-infiltrating immune cells and tumor growth.Furthermore,the expression of A3A in tumor cells may directly affect their proliferation and migration.A growing body of research has unveiled that A3A is closely related to various cancers,which signifies the potential significance of A3A in cancer therapy.This paper mainly classifies and summarizes the evidence of the relationship between A3A and tumorigenesis based on the potential mechanisms,aiming to provide valuable references for further research on the functions of A3A and its development in the area of cancer therapy.

关 键 词：APOBEC3A DEAMINASE Mutation DNADAMAGE TUMORIGENESIS Tumor-associatedviruses MACROPHAGE Tumormicroenvironment 

分 类 号：R73[医药卫生—肿瘤]