ADATs:roles in tRNA editing and relevance to disease  

作　　者：Xue-Ling Mao Gilbert Eriani Xiao-Long Zhou 

机构地区：[1]Key Laboratory of RNA Innovation,Science and Engineering,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China [2]Architecture et Réactivitéde l′ARN,Institut de Biologie Moléculaire et Cellulaire du CNRS,Universitéde Strasbourg,2 allée Konrad Roentgen,67084 Strasbourg,France [3]Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China

出　　处：《Acta Biochimica et Biophysica Sinica》2025年第1期73-83,共11页生物化学与生物物理学报(英文版)

基　　金：supported by the grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0570000);the National Key Research and Development Program of China(Nos.2021YFA1300800 and 2021YFC2700903);the Natural Science Foundation of China(No.32271300);the Committee of Science and Technology in Shanghai(Nos.22ZR1481300 and 22JC1400503);the CAS Project for Young Scientists in Basic Research(No.YSBR-075).

摘　　要：Transfer RNAs(tRNAs)play central roles in protein biosynthesis.Post-transcriptional RNA modifications affect tRNA function and stability.Among these modifications,RNA editing is a widespread RNA modification in three domains of life.Proteins of the adenosine deaminase acting on tRNA(ADAT)family were discovered more than 20 years ago.They catalyze the deamination of adenosine to inosine(A-to-I)or cytidine to uridine(C-to-U)during tRNA maturation.The most studied example is the TadA-or ADAT2/3-mediated A-to-I conversion of the tRNA wobble position in the anticodon of prokaryotic or eukaryotic tRNAs,respectively.This review provides detailed information on A-to-I and C-to-U editing of tRNAs in different domains of life,presents recent new findings on ADATs for DNA editing,and finally comments on the association of mutations in the ADAT3 gene with intellectual disability.

关 键 词：tRNA editing DEAMINASE TadA ADAT2/3 

分 类 号：Q78[生物学—分子生物学]