METHYLTRANSFERASE

作品数：118被引量：630H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：张燕肖勇梅陈韵聪谢春姣刘汝青更多>>
相关机构：华中科技大学中国科学院大学广州市第十二人民医院广州市疾病预防控制中心更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金福建省自然科学基金更多>>
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N6-methyladenosine methyltransferase Wilms tumor 1-associated protein impedes diabetic wound healing through epigenetically activating DNA methyltransferase 1
《World Journal of Diabetes》2025年第3期232-242,共11页Ren-Jie Xiao Tian-Jiao Wang Dan-Yin Wu Shui-Fa Yang Hai Gao Pei-Dong Gan Yang-Yan Yi You-Lai Zhang 
BACKGROUND Diabetic wound injury is a significant and common complication in individuals with diabetes.N6-methyladenosine(m6A)-related epigenetic regulation is widely involved in the pathogenesis of diabetes complicat...
关键词：Diabetic wound healing N6-methyladenosine Wilms tumor 1-associated protein DNA methyltransferase 1 Human umbilical vein endothelial cells 
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis
《Signal Transduction and Targeted Therapy》2025年第1期471-472,共2页Han Yan Wenjun Liu Rui Xiang Xin Li Song Hou Luzheng Xu Lin Wang Dong Zhao Xingkai Liu Guoqing Wang Yujing Chi Jichun Yang 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-024-01914-0,published online 08 August 2024 In the process of collating the raw data,the authors noticed one inadvertent mistake in...
关键词：HEPATIC CORRECTION repeatedly 
Pre-transplantation levels of lysine(K)-specific methyltransferase 2A(KMT2A)partial tandem duplications can predict relapse of acute myeloid leukemia patients following haploidentical donor hematopoietic stem cell transplantation
《Blood Science》2024年第4期52-59,共8页Dao-Xing Deng Xiao-Hang Ma Ze-Hua Wu Xiao-Hui Zhang Lan-Ping Xu Yu Wang Chen-Hua Yan Huan Chen Yu-Hong Chen Wei Han Feng-Rong Wang Jing-Zhi Wang Xiao-Jun Huang Xiao-Su Zhao Xiao-Dong Mo 
supported by the National Key Research and Development Program of China(2021YFC2500300,2022YFC2502606);the Grants from the Beijing Municipal Science and Technology Commission(Z221100007422008);Major Program of the National Natural Science Foundation of China(82293630,82293633);CAMS Innovation Fund for Medical Sciences(2022-I2M-C&T-B-121,2023-I2MC&T-B-123);Peking University People’s Hospital Research and Development Funds(RD2023-08);Tongzhou District Distinguished Young Scholars(JCQN2023009);the Fundamental Research Funds for the Central Universities。
We aimed to identify dynamic changes of lysine(K)-specific methyltransferase 2A partial tandem duplications(KMT2A-PTD)before and after haploidentical donor hematopoietic stem cell transplantation(HID HSCT)and explore ...
关键词：Acute myeloid leukemia Allogeneic hematopoietic stem cell transplantation HAPLOIDENTICAL KMT2A-PTD RELAPSE 
Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2
《Acta Biochimica et Biophysica Sinica》2024年第12期1848-1859,共12页Yong Ji Yang Wang Jiacheng Zou Guanghao Liu Mingyu Xia Jun Ren Daorong Wang 
supported by the grants from the National Natural Science Foundation of China(No.81972269);the Key Laboratory of Basic and Clinical Transformation of Digestive and Metabolic Diseases,Yangzhou,China(No.YZ2020159);the Application of Fluorescence Imaging in Minimally Invasive Surgery for Low Rectal Cancer(No.ZD2022047).
Aberrant DNA methylation patterns in the promoter region of PLCG2 are associated with dysregulated signaling pathways and cellular functions.Its role in colorectal cancer cells is still unknown.In this study,qRT-PCR i...
关键词：EPIGENETICS DNA methylation DNMT3B PLCG2 colorectal cancer 
The METHYLTRANSFERASE B-SERRATE interaction mediates the reciprocal regulation of microRNA biogenesis and RNA m^(6)A modification
《Journal of Integrative Plant Biology》2024年第12期2613-2631,共19页Haiyan Bai Yanghuan Dai Panting Fan Yiming Zhou Xiangying Wang Jingjing Chen Yuzhe Jiao Chang Du Zhuoxi Huang Yuting Xie Xiaoyu Guo Xiaoqiang Lang Yongqing Ling Yizhen Deng Qi Liu Shengbo He Zhonghui Zhang 
supported by the National Natural Science Foundation of China(32170593 and 31771349);the Guangdong Provincial Pearl River Talent Plan(2019QN01N108);the National Science Foundation of Guangdong Province,China(Grant No.2020B1515020007);the State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources(SKLCUSA-b202006)to Z.Z.;a double first-class discipline promotion project of Guangdong province(2021B10564001)and the Guangdong Provincial Pearl River Talent Plan(2021QN020536)to S.H.;the Elite Rice Plan of Rice Research Institute,Guangdong Academy of Agricultural Sciences(2022YG01)to Q.L.
In eukaryotes,RNA N6-methyladenosine(m^(6)A)modification and microRNA(miRNA)-mediated RNA silencing represent two critical epigenetic regulatory mechanisms.The m^(6)A methyltransferase complex(MTC)and the microprocess...
关键词：iquid-liquid phase separation microRNA biogenesis MTB RNA m^(6)A modification SE 
Heat stress-induced decapping of WUSCHEL mRNA enhances stem cell thermotolerance in Arabidopsis
《Molecular Plant》2024年第12期1820-1832,共13页Sumei Liu Haijun Wu Zhong Zhao 
National Natural Science Foundation of China(grant nos.32321001 and 32130009 to Z.Z.);University of Science and Technology of China Research Funds of the Double First-Class Initiative(grant no.YD9100002025 to Z.Z.).
The plasticity of stem cells in response to environmental change is critical for multicellular organisms.Here,we show that MYB3R-like directly activates the key plant stem-cell regulator WUSCHEL(WUS)by recruiting the ...
关键词：WUSCHEL DECAPPING MYB3R-like METHYLTRANSFERASE THERMOTOLERANCE 
The Clausena lansium genome provides new insights into alkaloid diversity and the evolution of the methyltransferase family
《Journal of Integrative Agriculture》2024年第10期3537-3553,共17页Yongzan Wei Yi Wang Fuchu Hu Wei Wang Changbin Wei Bingqiang Xu Liqin Liu Huayang Li Can Wang Hongna Zhang Zhenchang Liang Jianghui Xie 
supported by the Central Public-interest Scientific Institution Basal Research Fund for the Chinese Academy of Tropical Agricultural Sciences(1630062019010 and 1630062020010);the Fund of Protection of Species Resources for the Ministry of Agriculture and Rural Affairs of China(125A0605)。
Wampee(Clausena lansium)is an important evergreen fruit tree native to southern China that has a long history of use for medicinal purposes.Here,a chromosome-level genome of C.lansium was constructed with a genome siz...
关键词：Clausena lansium GENOME EVOLUTION methyltransferase activity alkaloid biosynthesis coumarin accumulation 
Targeting methyltransferase-like 5-mediated sphingomyelin metabolism:A novel therapeutic approach in gastric cancer
《World Journal of Gastrointestinal Oncology》2024年第10期4060-4063,共4页Jin-Juan Zhang Chang Yuan Sheng-Chun Dang 
Supported by Jiangsu Commission of Health,No.LKZ2023012;Social Development Project of Zhenjiang City,No.SS2023011.
Gastric cancer(GC)is a global health problem and a leading cause of cancerrelated deaths,with its mortality rate ranking third among all cancers.The etiology and progression of GC are characterized by a complex interp...
关键词：Gastric cancer Methyltransferase-like 5 Sphingomyelin metabolism Biomarkers Chemotherapy response 
Selenocysteine methyltransferase SMT catalyzed the synthesis of Se-methylselenocysteine to regulate the accumulation of glucosinolates and sulforaphane in broccoli
《Horticultural Plant Journal》2024年第5期1151-1164,共14页Qi Wu Junwei Wang Yuxiao Tian Chunyan Zhou Shuxiang Mao Qiuyun Wu Ke Huang 
the Projects of International Cooperation National Key R&D Program of China(Grant No.2022YFE0108300);the National Key Research and Development Program of China(Grant No.2022YFF1003000);the National Natural Science Foundation of China(Grant Nos.32372682,32272747,32072585,32072568).
Selenocysteine methyltransferase(SMT)is a key enzyme involved in the Se metabolism pathway,and it is responsible for the catalysis of Se-methylselenocysteine(SeMSC)compound formation.Previous studies showed that selen...
关键词：Selenocysteine methyltransferase Transgenic broccoli Se-methylselenocysteine Glucosinolate sulforaphane Selenium 
SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma被引量：1
《Cell Research》2024年第9期648-660,共13页Bisi Miao Ling Ge Chenxi He Xinghao Wang Jibo Wu Xiang Li Kun Chen Jinkai Wan Shenghui Xing Lingnan Ren Zhennan Shi Shengnan Liu Yajun Hu Jiajia Chen Yanyan Yu Lijian Feng Natasha M.Flores Zhihui Liang Xinyi Xu Ruoxin Wang Jian Zhou Jia Fan Bin Xiang En Li Yuanhui Mao Jingdong Cheng Kehao Zhao Pawel K.Mazur Jiabin Cai Fei Lan 
supported in part by grants from the National Natural Science Foundation of China(31925010 to F.L.,82272703 to J.Cai,32300461 to C.H.);the National Key R&D Program of China(2021YFA1300100 to F.L.);the Elite Youth Project of Natural Science Foundation of Fujian Province(2023J06056 to J.Cai);the China National Postdoctoral Program for Innovative Talents(BX20230098 to C.H.).
While lysine methylation is well-known for regulating gene expression transcriptionally,its implications in translation have been largely uncharted.Trimethylation at lysine 22(K22me3)on RPL40,a core ribosomal protein ...
关键词：HEPATOCELLULAR markedly TRANSLATION 
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