DNA methylation in the genesis,progress and prognosis of head and neck cancer  

作　　者：Zijian Guo Wenwen Liu Yuhan Yang Shunhao Zhang Chunjie Li Wenbin Yang 

机构地区：[1]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Head and Neck Oncology,West China Hospital of Stomatology,Sichuan University,Chengdu,China [2]Department of Geriatric Dentistry,Peking University School and Hospital of Stomatology,Beijing,China [3]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,No.14,Section 3,South Renmin Road,Chengdu 610041,China

出　　处：《Holistic Integrative Oncology》2023年第1期200-212,共13页整合肿瘤学（英文）

基　　金：supported by the Sichuan University-Panzhihua City 2021 Campus Cooperation Special Fund Project[grant number 2021CDPZH-7].

摘　　要：Epigenetic alteration studies in cancer research have been progressing rapidly in recent years.DNA methylation,including DNA hypermethylation and DNA hypomethylation,is one of the main epigenetic alterations in head and neck cancer development.Here,we review recent advances in DNA methylation and factors affecting DNA methylation,including DNA methylation enzymes,HPV status and smoking and drinking habits,in the field of head and neck cancer occurrence,progression,metastasis,and prognosis,hoping to shed light on how DNA methylation interacts with head and neck cancer and lay a foundation for future prognosis prediction and therapy.

关 键 词：Head and Neck Cancer(HNC) DNA Methylation DNA(Cytosine-5-)-Methyltransferases(DNMT) Ten-Eleven Translocation(TET) CARCINOGENESIS 

分 类 号：R730.2[医药卫生—肿瘤]