Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease  

作　　者：Li Xu Yu-Hong Fan Xiao-Jing Zhang Lan Bai 

机构地区：[1]State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases,Gannan Innovation and Translational Medicine Research Institute,Gannan Medical University,Ganzhou 341000,China [2]School of Basic Medical Sciences,Wuhan University,Wuhan 430060,China

出　　处：《World Journal of Hepatology》2024年第5期703-715,共13页世界肝病学杂志（英文版）（电子版）

摘　　要：Non-alcoholic fatty liver disease(NAFLD)poses a significant health challenge in modern societies due to shifts in lifestyle and dietary habits.Its complexity stems from genetic predisposition,environmental influences,and metabolic factors.Epigenetic processes govern various cellular functions such as transcription,chromatin structure,and cell division.In NAFLD,these epigenetic tendencies,especially the process of histone methylation,are intricately intertwined with fat accumulation in the liver.Histone methylation is regulated by different enzymes like methyltransferases and demethylases and influences the expression of genes related to adipogenesis.While early-stage NAFLD is reversible,its progression to severe stages becomes almost irreversible.Therefore,early detection and intervention in NAFLD are crucial,and understanding the precise role of histone methylation in the early stages of NAFLD could be vital in halting or potentially reversing the progression of this disease.

关 键 词：Non-alcoholic fatty liver disease MECHANISM Histone methylation METHYLTRANSFERASES Demethytrasferases Epigenetic modification ADIPOGENESIS 

分 类 号：R575.5[医药卫生—消化系统] R749.4[医药卫生—内科学]