云南高校图书馆联盟文献共享服务平台- GPCRS

GPCRS: 作品数：68被引量：110H指数：6; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：陈京金艳燕黄思罗白波徐志卿更多>>; 相关机构：济宁医学院华中科技大学南京邮电大学首都医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划湖南省自然科学基金更多>>

GPR34 senses demyelination to promote neuroinflammation and pathologies被引量：1: 《Cellular & Molecular Immunology》2024年第10期1131-1144,共14页Bolong Lin Yubo Zhou Zonghui Huang Ming Ma Minghui Qi Zhongjun Jiang Guoyang Li Yueli Xu Jiaxian Yan Di Wang Xiaqiong Wang Wei Jiang Rongbin Zhou; supported by the National Key Research and Development Program of China(grant number 2020YFA0509101);the National Natural Science Foundation of China(grant numbers 81821001,82130107,U20A20359);the CAS Project for Young Scientists in Basic Research(YSBR-074).; Sterile neuroinflammation is a major driver of multiple neurological diseases.Myelin debris can act as an inflammatory stimulus to promote inflammation and pathologies,but the mechanism is poorly understood.Here,we sh...; 关键词：NEUROINFLAMMATION GPCRS MICROGLIA

趋化素受体的研究进展: 《生物化工》2024年第4期194-200,共7页常晓华汤语萱罗天煜吴蓓丽何茂洲; 浙江省自然科学基金(LQ24C050004)。; 趋化素受体是G蛋白偶联受体(G Protein-Coupled Receptors,GPCRs)家族的重要成员,广泛分布于人体各组织器官中,参与炎症反应、血管生成、脂质和葡萄糖代谢等多种生理过程,与炎症性疾病、癌症、代谢综合征等多种疾病的发生发展密切相关...; 关键词：G蛋白偶联受体(GPCRs) 趋化素趋化素受体药物研发

GPCRs involved in metabolic diseases:pharmacotherapeutic development updates被引量：1: 《Acta Pharmacologica Sinica》2024年第7期1321-1336,共16页Cheng Jin Hui Chen Li Xie Yuan Zhou Li-li Liu Jian Wu; supported partially by the National Natural Science Foundation of China (NSFC#82370625,82170624,81871997,81572356);the National Key R&D Program of China (#2016YFE0107400)to J.W.; G protein-coupled receptors(GPCRs)are expressed in a variety of cell types and tissues,and activation of GPCRs is involved in enormous metabolic pathways,including nutrient synthesis,transportation,storage or insulin ...; 关键词：G protein-coupled receptor ANTAGONIST AGONIST diabetes metabolic syndrome nonalcoholic steatohepatitis

红芪多糖经SCFAs-GPCRs改善脾气虚型DGP大鼠小肠动力的机制研究: 《中华中医药杂志》2024年第7期3436-3441,共6页魏昭晖李荣科张磊刘苗万生芳; 国家自然科学基金项目(No.82060914);中医学一流学科“岐黄英才”导师专项基金;甘肃省优秀博士生项目(No.23JRRA1225);甘肃中医药大学研究生创新项目(No.2022-07)。; 目的:观察红芪多糖(HPS)对脾气虚型糖尿病胃轻瘫(DGP)大鼠短链脂肪酸(SCFAs)-G蛋白偶联受体(GPCRs)的影响,探讨HPS改善脾气虚型DGP大鼠小肠动力的可能机制。方法:72只SPF级Wistar雄性大鼠随机分为空白组(10只)和造模组(62只),造模组采...; 关键词：糖尿病胃轻瘫红芪多糖 G蛋白偶联受体短链脂肪酸肠动力机制动物模型

Exploring structure-based drug discovery of GPCRs beyond the orthosteric binding site: 《hLife》2024年第5期211-226,共16页Zhao Chen Xintong Ren Yu Zhou Niu Huang; This work is supported by Beijing Municipal Science&Technology Commission(Z201100005320012 to N.H.)and Tsinghua University.; G-protein coupled receptors(GPCRs)are the largest family of druggable targets.In recent years,GPCR structural biology has made great advances,revealing the three-dimensional structures of many GPCRs and their interact...; 关键词：G-protein coupled receptor(GPCR) allosteric pocket structure-based virtual screening(SBVS) negative allosteric modulator(NAM) positive allosteric modulator(PAM) artificial intelligence(AI)

G protein-coupled receptors(GPCRs):advances in structures,mechanisms,and drug discovery被引量：1: 《Signal Transduction and Targeted Therapy》2024年第5期1938-1980,共43页Mingyang Zhang Ting Chen Xun Lu Xiaobing Lan Ziqiang Chen Shaoyong Lu; This study was supported by grants from the National Key R&D Program of the Ministry of Science and Technology(No.2023YFC3404700);the National Natural Science Foundation of China(No.22077082);the Shanghai Frontiers Science Center of Cellular Homeostasis and the Human Diseases,and the Innovative Research Team of High-Level Local Universities in Shanghai.; G protein-coupled receptors(GPCRs),the largest family of human membrane proteins and an important class of drug targets,play a role in maintaining numerous physiological processes.Agonist or antagonist,orthosteric eff...; 关键词：STERIC DESIGNING MECHANISMS

GPCRs andβ-arrestins—an on-off relationship: 《Cell Research》2023年第11期819-820,共2页Alex R.B.Thomsen; Traditionally,G protein-coupled receptor(GPCR)-mediated G protein signaling has been thought to be terminated by receptor phosphorylation followed by recruitment ofβ-arrestins,which uncouples G protein from the recep...; 关键词：al. terminated INSIGHT

A promising small molecule binding pocket in class B GPCRs: expanding potential for drug development被引量：1: 《Signal Transduction and Targeted Therapy》2023年第9期3888-3889,共2页Huan Xiao Qian Sun Qiu Sun; This work was supported by Natural Science Foundation of Sichuan Province(Grants 2023NSFSC1839,2023NSFSC1154).; Recently,Xu et al.1 have published in Nature,solved the high-resolution structure of a small molecule agonist PCO371 and Gs bound human parathyroid hormone receptor 1(PTH1R)by cryo-electron microscopy.This study revea...; 关键词：EXPANDING INSIGHT CLASS

利用深度迁移学习靶向GPCRs的配体活性预测: 《计算机工程与应用》2023年第13期120-128,共9页汤丽华卢宁兰闯闯陈荣华吴建盛; 国家自然科学基金(61872198,61971216,81771478,81973512);江苏省科技厅基础研究计划(自然科学基金)面上项目(BK20201378)。; G蛋白偶联受体(GPCRs)是最重要的药物靶标之一,约占市场上药物靶标的34%。药物发现过程中,配体生物活性的准确建模和解释对于筛选苗头化合物至关重要。研究表明,同源的G蛋白偶联受体能提升配体分子生物活性的预测性能和可解释性。提出...; 关键词：G蛋白偶联受体(GPCRs) 扩展连通性指纹配体活性多任务学习深度迁移学习

化学遗传学技术在精神疾病研究中的应用被引量：1: 《中国药物依赖性杂志》2023年第3期173-179,共7页刘芳林李鑫韩盈; 国家自然科学基金(32071058);。; 精神疾病具有机制复杂、复发率高等特点,一直是重大的医学和社会问题。在精准医疗方针的指导下,化学遗传学技术通过精确调控特定类型神经元或神经胶质细胞,为精神疾病中神经环路机制的研究模式带来重大变革,在探寻和证实精神疾病背后的...; 关键词：化学遗传学技术精神疾病 DREADD技术 GPCRS 神经环路

GPCRS