Chiralα-tertiary amines and related azacycles are commonly found in many natural products,pharmaceuticals and agrochemicals[1].Copper-catalyzed asymmetric propargylic amination(APA)reactions have been established as ...
supported by the European Research Council(grant no.695009);the UK Engineering and Physical Sciences Research Council(EPSRC,grant nos.EP/T031603/1 and EP/P027067/1).
Macrocycles have found uses in guest capture,sensing,and porous materials,motivating the development of new methods for their synthesis.Here we report the construction of two types of barrelshaped macrocyclic assembli...
financially supported by the National Natural Science Foundation of China(Nos.22122110 and U23B6011 for Z.J.);the Jilin Provincial Science and Technology Department Program(No.20210101070JC for Y.C.)。
Olefin polymerization is one of the most im portant chemical reactions in industry.This work presents a strategy that emphasizes the synergistic meta/poro-steric hindrance of N-aryl groups and electronic effects in ne...
supported by the Natural Science Foundation of Nanjing University of Posts and Telecommunications(NY222157,NY221085);State Key Laboratory of Organic Electronics and Information Display(GZR2022010008);Key Laboratory of Low-dimensional Materials Chemistry of Jiangsu Province(JSKC20022);General Program of China Postdoctoral Science Foundation(2022M711684);General Program of Basic Science(Natural Science)of Colleges and Universities of Jiangsu Province(22KJB430036);National Overseas Study Fund(202008320051);National Key Laboratory(2009DS690095);the National Natural Science Foundation of China(62288102).
Stability against oxygen is an important factor affecting the performance of organic semiconductor devices.Improving photooxidation stability can prolong the service life of the device and maintain the mechanical and ...
This study was supported by grants from the National Key R&D Program of the Ministry of Science and Technology(No.2023YFC3404700);the National Natural Science Foundation of China(No.22077082);the Shanghai Frontiers Science Center of Cellular Homeostasis and the Human Diseases,and the Innovative Research Team of High-Level Local Universities in Shanghai.
G protein-coupled receptors(GPCRs),the largest family of human membrane proteins and an important class of drug targets,play a role in maintaining numerous physiological processes.Agonist or antagonist,orthosteric eff...
The selective functionalization of C(sp^(3))–H bonds with subtle differences in alkanes is highly sought after due to its atom-and step-efficiency.The activation of C(sp^(3))–H bonds through hydrogen atom transfer(H...
supported by National Natural Science Foundation of China(No.82173766,82104109);Natural Science Foundation of Liaoning Province(2022-BS158);Liaoning Province Applied Basic Research Program(No.2022JH2/101300097);National Key R&D Program of China(No.2022YFE0111600).
The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking of disulfide bonds is triggered by small amounts of ...
the Shanghai Jiao Tong University School of Medicine and Ningxia Medical University for their support of this research project.Funding:This research was supported in part by grants from the National Key R&D Program of China(2022YFF1203005);the National Natural Science Foundation of China(22077082,21778037,81925034,91753117,and 81721004);the Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-01-E00036,China);the Shanghai Science and Technology Innovation(19431901600,China);the Shanghai Health and Family Planning System Excellent Subject Leader and Excellent Young Medical Talents Training Program(2018BR12,China).
Importance:Allosteric drugs bound to topologically distal allosteric sites hold a substantial promise in modulating therapeutic targets deemed undruggable at their orthosteric sites.Traditionally,allosteric modulator ...
supported by Researchers Supporting Project number(RSP2023R455),King Saud University,Riyadh,Saudi Arabia。
Herein,iron oxide/hydroxides deposits(gossans)were utilized,for the first time,in the fabrication of magnetite nanoparticles(MNPs)to load modified coal(MC).The as-synthesized MNPs@MC composite was characterized via di...
supported by the National Natural Science Foundation of China (21905205 and 22109037);the Natural Science Foundation of Tianjin City (20JCYBJC00380);the Advanced Talents Incubation Program of Hebei University (521000981408);the Haihe Laboratory of Sustainable Chemical Transformations(YYJC202110)。
Redox p-type organic compounds are promising cathode materials for dual-ion batteries.However,the triphenylamine-based polymers usually with agglomerate and intertwined molecular chain nature limit the maximum reactio...