Terminal-selective C(sp^(3))-H borylation of unbranched alkanes enabled by intermolecular radical sampling and LMCT photocatalysis  

作　　者：Zhexuan Lei Jie Wu 

机构地区：[1]Department of Chemistry,National University of Singapore,Singapore

出　　处：《National Science Review》2024年第5期89-91,共3页国家科学评论（英文版）

摘　　要：The selective functionalization of C(sp^(3))–H bonds with subtle differences in alkanes is highly sought after due to its atom-and step-efficiency.The activation of C(sp^(3))–H bonds through hydrogen atom transfer(HAT)has been extensively exploited to produce a valueadded product from unfunctionalized material[1,2].Despite the advancements in HAT chemistry,the activation of inert C(sp^(3))–H bonds under mild conditions requires a highly reactive HAT reagent,often exhibiting poor site selectivity.Prominent studies on selective C(sp^(3))–H functionalization through HAT have been reported,mainly exploiting the differences in steric hinderance of various C(sp^(3))–H bonds,achieving site-selective HAT followed by functionalization(Fig.1 A)[3–5].However,these methods rarely produce ideal site selectivity with straight-chain substrates(seldomly exceeding 50%for terminal C(sp^(3))–H)where the steric difference between primary and secondary C(sp^(3))−H bonds is subtle.

关 键 词：BONDS ALKANES STERIC 

分 类 号：O643.36[理学—物理化学] O644.1[理学—化学] TB383.1[一般工业技术—材料科学与工程]