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AGONIST: 作品数：331被引量：777H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：吴艺石琳冯磊马秋玲吴洁更多>>; 相关机构：苏州大学附属第三医院江苏省人民医院北京大学河南省中医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

Utilizing bivalent aptamers as first DNA agonist to activate RTKs heterodimer of different families: 《Chinese Chemical Letters》2025年第1期474-477,共4页Kun Liu Yulin Cong Xiongfeng Luo Meicun Yao Zhiyong Xie Hao Li; the National Natural Science Foundation of China(Nos.22104158,82174104,U1903211);the Natural Science Foundation of Hunan Province(No.2021JJ40041);Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011346);Shenzhen Science and Technology Program(No.SZBH202130)。; Heterodimerization in RTKs is of vital importance in the RTK signaling and cell functions.Heterodimerization between RTKs can result in diversity of downstream signals,increasing the ability of cells to respond to ext...; 关键词：DNA Agonist Bivalent aptamers RTKs heterodimer

Elafibranor, a dual PPARα and PPARδ agonist, reduces alcoholassociated liver disease: Lessons from a mouse model: 《World Journal of Gastroenterology》2025年第4期156-159,共4页Luciano Pirola; Metabolic dysfunction-associated steatotic liver disease(MASLD)is a highly prevalent liver pathology in need of novel pharmacological treatments to complement lifestyle-based interventions.Nuclear receptor agonists ha...; 关键词：PPAR nuclear receptors Elafibranor Steatotic liver disease Alcoholassociated liver disease Liver fibrosis

Therapeutic potential of elafibranor in alcohol-associated liver disease: Insights into macrophage modulation and fibrosis reduction: 《World Journal of Biological Chemistry》2025年第1期1-9,共9页Samira Farhadi Saeed Mohammadi Abdulaziz Y AlKindi Issa S Al-Amri; Alcohol-associated liver disease(ALD)is a major global health concern,contributing to liver injury,morbidity,and mortality.Elafibranor(EFN),a dual peroxisome proliferator-activated receptorα/δagonist,has shown promi...; 关键词：Alcohol-associated liver disease Elafibranor Peroxisome proliferator-activated receptorα/δagonist MACROPHAGES Liver fibrosis Inflammatory responses

Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation: 《Protein & Cell》2024年第12期889-905,共17页Mengxue Zeng Kun Wang Qingcui Wu Jingjin Ding Dan Xie Xiangbing Qi Feng Shao; supported by the National Key R&D Program of China(2022YFA1304700);the CAS Strategic Priority Research Program(XDB37030202);the Basic Science Center Project(82388201)of NSFC;the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-084);F.S.is also supported by the Tencent New Cornerstone Investigator Program.; Caspase-2,a highly conserved member of the caspase family,is considered an initiator caspase that triggers apoptosis in response to some cellular stresses.Previous studies suggest that an intracellular multi-protein c...; 关键词：caspase-2 PIDDosome BID apoptosis chemical screen AGONIST

Molecular Mechanism of Action of GPR91 Agonists and Antagonists:Insights from Molecular Dynamics Simulation: 《Chemical Research in Chinese Universities》2024年第6期1201-1211,共11页ZHANG Junjie LV Lunan ZHU Haoran ZHANG Ying XU Xiaodi LONG Lanxin FU Wei; supported by the National Natural Science Foundation of China(Nos.82073765,82273853).; G protein-coupled receptor 91(GPR91)has garnered widespread attention as a prospective therapeutic target for metabolic diseases.However,no structural data for human GPR91(hGPR91);detailed molecular mechanism of actio...; 关键词：G protein-coupled receptor 91(GPR91) Mechanism of action(MOA) AGONIST ANTAGONIST Molecular dynamics(MD)

FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis: 《Acta Pharmacologica Sinica》2024年第11期2313-2327,共15页Ying-quan Wen Zi-yuan Zou Guan-guan Zhao Meng-jiao Zhang Yong-xin Zhang Gai-hong Wang Jing-jing Shi Yuan-yang Wang Ye-yu Song Hui-xia Wang Ru-ye Chen Dong-xuan Zheng Xiao-qun Duan Ya-meng Liu Frank J.Gonzalez Jian-gao Fan Cen Xie; supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39020600);National Key Research and Development Program of China(2021YFA1301200);National Natural Science Foundation of China(82222071,91957116,82173873);and Project supported by Shanghai Municipal Science and Technology Major Project.; The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis(MASH)to the forefront of public health concerns.The activation of FXR shows promise to combat MASH a...; 关键词：MASLD/MASH FXR TRANSCRIPTOME gut-liver axis AGONIST

A Case of Severe Cholestatic Hepatitis Induced by a Novel Dual Agonist of Glucagon-like Peptide-1 and Glucosedependent Insulinotropic Polypeptide Receptors: 《Journal of Clinical and Translational Hepatology》2024年第11期949-954,共6页Junmin Jiang Meifeng Shi Shuduo Wu Minling Cao; Glucagon-like peptide-1(GLP-1)and glucose-dependent insulinotropic polypeptide(GIP)receptor agonists are increasingly used in the management of type 2 diabetes mellitus and obesity due to their ability to stimulate in...; 关键词：GLP-1 receptor GIP receptor Cholestatic hepatitis OBESITY

Dual-function natural products:Farnesoid X receptor agonist/inflammation inhibitor for metabolic dysfunction-associated steatotic liver disease therapy被引量：1: 《Chinese Journal of Natural Medicines》2024年第11期965-976,共12页WANG Kang ZHANG Pengfei SUN Huiyong CUI Shuang AO Lanjia CUI Ming XU Xiaowei WANG Lin XU Yuanyuan WANG Guangji WANG Hong HAO Haiping; supported by the National Natural Science Foundation of China(Nos.81930109,82321005,82073926,82373946 and 82073928);the Major State Basic Research DevelopmentProgramofChina(Nos.2021YFA1301300and 2022YFA1303800);Overseas Expertise Introduction Project for Discipline Innovation(No.G20582017001);the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University(Nos.SKLNMZZ202202 and SKLNMZZ202402);the Fundamental Research Funds for the Central Universities(No.2632023TD10);the Project Program of Basic Science Research Center Base(Pharmaceutical Science)of Yantai University(No.Y202204).; Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most prevalent chronic liver disease globally,with only one Food and Drug Administration(FDA)-approved drug for its treatment.Given MASLD's complex...; 关键词：FXR agonist INFLAMMATION Dual modulator Natural products MASLD

Amylovis-201 is a new dual-target ligand,acting as an anti-amyloidogenic compound and a potent agonist of the σ_(1) chaperone protein: 《Acta Pharmaceutica Sinica B》2024年第10期4345-4359,共15页Laura Garcia-Pupo Lucie Crouzier Alberto Bencomo-Martinez Johann Meunier Axelle Morilleau Benjamin Delprat Marquiza Sablon Carrazana Roberto Menendez Soto del Valle Tangui Maurice Chryslaine Rodriguez-Tanty; supported by a PHC Carlos J.Finlay program from Campus France(project 47069SA)to TM and CRT.; The aggregation of Amyloid-β(Aβ)peptides is associated with neurodegeneration in Alzheimer's disease(AD).We previously identified novel naphtalene derivatives,including the lead compound Amylovis-201,able to form th...; 关键词：Alzheimer’s disease Amyloid-b aggregation Neuroprotection s1 receptor Drug discovery Molecular modelisation Zebrafish model Learning and memory

Surgical or medical treatment of obesity-associated type 2 diabetesan increasing clinical conundrum: 《World Journal of Diabetes》2024年第10期2036-2040,共5页Ryan J Jalleh Karen L Jones Md Shahidul Islam Lu Cai Michael Horowitz; In this editorial,we comment on the article by He et al,specifically in relation to the efficacy of bariatric surgery vs glucagon-like peptide-1 receptor agonist(GLP-1RA)therapy in the management of type 2 diabetes(T2...; 关键词：Glucagon-like peptide-1 Glucagon-like peptide-1 receptor agonist OBESITY DIABETES Weight loss Bariatric surgery Metabolic surgery HYPOGLYCEMIA

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