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AGONIST: 作品数：335被引量：779H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：吴艺石琳冯磊马秋玲吴洁更多>>; 相关机构：苏州大学附属第三医院江苏省人民医院北京大学河南省中医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

Dual effects of GABA_(A)R agonist anesthetics in neurodevelopmentnd vulnerable brains:From neurotoxic to therapeutic effects: 《Neural Regeneration Research》2026年第1期81-95,共15页Dihan Lu Wen Zhang Keyu Chen Xia Feng; Debates regarding the specific effects of general anesthesia on developing brains have persisted for over 30 years.A consensus has been reached that prolonged,repeated,high-dose exposure to anesthetics is associated w...; 关键词：brain central nervous system cognition gamma-aminobutyric acid type A receptor agonist general anesthetics neurogenesis neurological disorders neuroprotection NEUROTOXICITY signal pathways

Anemia risk and mitigation strategies in type 2 diabetic patients:The role of novel antidiabetic agents: 《World Journal of Diabetes》2025年第5期119-123,共5页Petra Meliš Maja Cigrovski Berkovic; Anemia is a common yet often overlooked complication in patients with type 2 diabetes mellitus(T2DM),particularly those with chronic kidney disease.It significantly impacts patients'quality of life,cardiovascular heal...; 关键词：ANEMIA Type 2 diabetes mellitus chronic kidney disease Iron deficiency METFORMIN Sodium-glucose cotransporter-2 inhibitors Glucagon-like peptide-1 receptor agonist Glucagon-like peptide-1 receptor agonist/GIP dual agonists

Effect of beinaglutide,a thrice-daily GLP-1 receptor agonist,on body weight and metabolic parameters:A systematic review and metaanalysis: 《World Journal of Diabetes》2025年第5期374-387,共14页Abul Bashar Mohammad Kamrul-Hasan Vanishri Ganakumar Lakshmi Nagendra Deep Dutta M Rafiqul Islam Joseph M Pappachan; BACKGROUND Beinaglutide,a short-acting glucagon-like polypeptide-1 receptor agonist,has shown variable efficacy in weight reduction and metabolic control in randomized controlled trials(RCTs).AIM To summarize the ther...; 关键词：Beinaglutide Glucagon-like polypeptide-1 receptor agonist OBESITY Type 2 diabetes Weight reduction Metaanalysis

Drug discovery targeting thyroid hormone receptor b (THRb) for the treatment of liver diseases and other medical indications: 《Acta Pharmaceutica Sinica B》2025年第1期35-51,共17页Kean Wang Feiyang Chen Jiang Wang Hong Liu; the National Natural Science Foundation of China(82130105,22337003,and 82121005 to Hong Liu,and 82322063,22177124 to Jiang Wang);the Lingang Laboratory(LG-GG-202403-01 to Jiang Wang,China);Program of Shanghai Academic Research Leader(23XD1460300 to Jiang Wang,China).; Thyroid hormone receptors(THRs),a crucial nuclear receptor protein family,primarily consist of two categories:a receptors and b receptors.Among them,THRb is the primary subtype of thyroid hormone that confers benefits...; 关键词：Thyroid hormone Thyroid hormoneβreceptor MASLD MASH THRβagonist

Utilizing bivalent aptamers as first DNA agonist to activate RTKs heterodimer of different families: 《Chinese Chemical Letters》2025年第1期474-477,共4页Kun Liu Yulin Cong Xiongfeng Luo Meicun Yao Zhiyong Xie Hao Li; the National Natural Science Foundation of China(Nos.22104158,82174104,U1903211);the Natural Science Foundation of Hunan Province(No.2021JJ40041);Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011346);Shenzhen Science and Technology Program(No.SZBH202130)。; Heterodimerization in RTKs is of vital importance in the RTK signaling and cell functions.Heterodimerization between RTKs can result in diversity of downstream signals,increasing the ability of cells to respond to ext...; 关键词：DNA Agonist Bivalent aptamers RTKs heterodimer

Elafibranor, a dual PPARα and PPARδ agonist, reduces alcoholassociated liver disease: Lessons from a mouse model: 《World Journal of Gastroenterology》2025年第4期156-159,共4页Luciano Pirola; Metabolic dysfunction-associated steatotic liver disease(MASLD)is a highly prevalent liver pathology in need of novel pharmacological treatments to complement lifestyle-based interventions.Nuclear receptor agonists ha...; 关键词：PPAR nuclear receptors Elafibranor Steatotic liver disease Alcoholassociated liver disease Liver fibrosis

Therapeutic potential of elafibranor in alcohol-associated liver disease: Insights into macrophage modulation and fibrosis reduction: 《World Journal of Biological Chemistry》2025年第1期1-9,共9页Samira Farhadi Saeed Mohammadi Abdulaziz Y AlKindi Issa S Al-Amri; Alcohol-associated liver disease(ALD)is a major global health concern,contributing to liver injury,morbidity,and mortality.Elafibranor(EFN),a dual peroxisome proliferator-activated receptorα/δagonist,has shown promi...; 关键词：Alcohol-associated liver disease Elafibranor Peroxisome proliferator-activated receptorα/δagonist MACROPHAGES Liver fibrosis Inflammatory responses

Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation: 《Protein & Cell》2024年第12期889-905,共17页Mengxue Zeng Kun Wang Qingcui Wu Jingjin Ding Dan Xie Xiangbing Qi Feng Shao; supported by the National Key R&D Program of China(2022YFA1304700);the CAS Strategic Priority Research Program(XDB37030202);the Basic Science Center Project(82388201)of NSFC;the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-084);F.S.is also supported by the Tencent New Cornerstone Investigator Program.; Caspase-2,a highly conserved member of the caspase family,is considered an initiator caspase that triggers apoptosis in response to some cellular stresses.Previous studies suggest that an intracellular multi-protein c...; 关键词：caspase-2 PIDDosome BID apoptosis chemical screen AGONIST

Molecular Mechanism of Action of GPR91 Agonists and Antagonists:Insights from Molecular Dynamics Simulation: 《Chemical Research in Chinese Universities》2024年第6期1201-1211,共11页ZHANG Junjie LV Lunan ZHU Haoran ZHANG Ying XU Xiaodi LONG Lanxin FU Wei; supported by the National Natural Science Foundation of China(Nos.82073765,82273853).; G protein-coupled receptor 91(GPR91)has garnered widespread attention as a prospective therapeutic target for metabolic diseases.However,no structural data for human GPR91(hGPR91);detailed molecular mechanism of actio...; 关键词：G protein-coupled receptor 91(GPR91) Mechanism of action(MOA) AGONIST ANTAGONIST Molecular dynamics(MD)

FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis: 《Acta Pharmacologica Sinica》2024年第11期2313-2327,共15页Ying-quan Wen Zi-yuan Zou Guan-guan Zhao Meng-jiao Zhang Yong-xin Zhang Gai-hong Wang Jing-jing Shi Yuan-yang Wang Ye-yu Song Hui-xia Wang Ru-ye Chen Dong-xuan Zheng Xiao-qun Duan Ya-meng Liu Frank J.Gonzalez Jian-gao Fan Cen Xie; supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39020600);National Key Research and Development Program of China(2021YFA1301200);National Natural Science Foundation of China(82222071,91957116,82173873);and Project supported by Shanghai Municipal Science and Technology Major Project.; The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis(MASH)to the forefront of public health concerns.The activation of FXR shows promise to combat MASH a...; 关键词：MASLD/MASH FXR TRANSCRIPTOME gut-liver axis AGONIST

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