A promising small molecule binding pocket in class B GPCRs: expanding potential for drug development  

作　　者：Huan Xiao Qian Sun Qiu Sun 

机构地区：[1]Department of Biotherapy,Cancer Center and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University/West China School of Nursing,Sichuan University,Chengdu 610041,China [2]West China Medical Publishers,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第9期3888-3889,共2页信号转导与靶向治疗（英文）

基　　金：This work was supported by Natural Science Foundation of Sichuan Province(Grants 2023NSFSC1839,2023NSFSC1154).

摘　　要：Recently,Xu et al.1 have published in Nature,solved the high-resolution structure of a small molecule agonist PCO371 and Gs bound human parathyroid hormone receptor 1(PTH1R)by cryo-electron microscopy.This study reveals a novel conserved small molecule agonist binding pocket of class B G protein-coupled receptors(GPCRs)and provides new insights into drug develop-ment for various therapeutic indications.GPCRs are a family of receptors with a seven transmembrane(7TM)domains that mediate various downstream signals by activating G proteins or recruitingβ-arrestins.As the largest family of cell membrane receptors encoded by the human genome,GPCRs are widely involved in human physiological and patholo-gical processes and have become the most important therapeutic targets.

关 键 词：EXPANDING INSIGHT CLASS 

分 类 号：R730[医药卫生—肿瘤]