ITCH

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神经介素B和受体对H9N2亚型流感病毒感染诱导的ITCH表达的影响
《畜牧兽医学报》2025年第4期1834-1842,共9页田世茂 田珂 刘玉钤 辜晴新 沈昀知 张骋怀 包银莉 杨桂红 
国家自然科学基金重点项目(U23A20235);国家自然科学基金项目(32030110);福建农林大学科技创新项目(KFB23100,KFB23094);福建农林大学大学生创业实践项目(202410389447);动物源性人兽共患病防控福建省高校工程研究中心开放基金课题项目(2023K05)。
甲型流感病毒(IAV)编码的基质蛋白1(M1)通过调控E3泛素连接酶ITCH介导的泛素化修饰反应拮抗宿主的抗病毒免疫反应。本课题前期研究表明,神经介素B(NMB)和其受体NMBR具有抑制IAV的先天性免疫应答反应的作用,但二者对IAV感染诱导的E3泛素...
关键词：神经介素B 神经介素B受体NMBR H9N2流感病毒 E3泛素连接酶ITCH 
Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets被引量：1
《Acta Pharmacologica Sinica》2025年第3期539-553,共15页Meng Sun Zhen-ru Chen Hui-juan Ding Jing Feng 
supported by grants from the National Natural Science Foundation of China(grant no.82171214 and 32241003);the Shanghai Municipal Natural Science Foundation(grant no.23ZR1474500);the State Key Laboratory of Chemical Biology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences.
Itch is an uncomfortable feeling that evokes a desire to scratch.This protective reflex can effectively eliminate parasites that invade the skin.When itchy skin becomes severe or lasts for more than six weeks,it has d...
关键词：ITCH GPCRS Mrgprs TRP channels CYTOKINES NEUROIMMUNE 
Baicalein ameliorates chronic itch in ACD mice by suppressing the spinal astrocytic STAT3–LCN2 cascade
《Acta Pharmacologica Sinica》2025年第2期366-379,共14页Li-xia Du Xin-yi Gao Xue-qi Ren Ya-yue Yang Yang-yang Ding Ao Xu Xiao-yu Wang Yu-xin Zhang Shi Shu Yu-fang Yang Wen-li Mi Zhi-fei Wang 
supported by the National Natural Science Foundation of China(82204830);the Shanghai Sailing Program(21YF1447500).
Chronic itch is a maladaptive and debilitating symptom in patients with allergic contact dermatitis(ACD),adversely affecting their quality of life.There is a lack of effective treatments for ACD-associated uncontrolla...
关键词：BAICALEIN chronic itch ASTROCYTES STAT3 LCN2 
Advances in the pathogenesis of postherpetic neurosymptoms of herpes zoster
《Infectious Diseases Research》2024年第4期27-34,共8页Yong-Fang Yang Xue-Min Yin Rong-Ping Ye Shu-Ya Zhou Xin-Ju Li 
Herpes zoster(HZ)is an acute infectious disease caused by varicella-zoster virus.The neurological sequelae of HZ include postherpetic neuralgia(PHN)and postherpetic itch(PHI).Severe pain and recurrent itching seriousl...
关键词：herpes zoster varicella-zoster virus postherpetic neuralgia postherpetic itch PATHOGENESIS 
Gluconacetobacter hansenii GK-1 Ingestion for 8 Weeks Improves Skin Discomfort in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study
《Food and Nutrition Sciences》2024年第11期1085-1094,共10页Mariko Oe Mengwei Yuan Keiko Kuriyama Yumi Takeda Mamoru Kimura Ryosuke Matsuoka Naoki Miura Jun Muto 
Gluconacetobacter hansenii GK-1 is an acid-resistant gram-negative bacterium used in vinegar brewing. Oral ingestion of GK-1 was previously reported to help maintain immunity and reduce nasal discomfort. Considering t...
关键词：Acetic Acid Bacteria Ingestion Skin Itch Paraprobiotics Functional Food 
Symptom burden in chronic liver disease
《Gastroenterology Report》2024年第1期671-678,共8页Ammar Hassan Ivonne Hurtado Diaz De Leon Elliot B.Tapper 
Chronic liver disease(CLD)is a significant contributor to global mortality.For people who are living with CLD,however,there is a substantial and often overlooked burden of physical and psychological symptoms that sign...
关键词：CIRRHOSIS SEX cramps ITCH FALLS FATIGUE 
The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch被引量：1
《Neuroscience Bulletin》2023年第12期1807-1822,共16页Juan Yao Xuan Li Guang-Yan Wu Bing Wu Jun-Hui Long Pu-Jun Wang Shu-Lei Liu Jie Gao Jian-Feng Sui 
supported by the National Natural Science Foundation of China(82271542);the Natural Science Foundation of Chongqing(cstc2020jcyj-msxm X0391 and cstc2019jcyj-msxm X0269);the Chongqing Medical Scientific Research Project(Joint project of Chongqing Health Commission and Science and Technology Bureau)(2023ZDXM001).
Itch is an unpleasant sensation that urges people and animals to scratch.Neuroimaging studies on itch have yielded extensive correlations with diverse cortical and subcortical regions,including the insular lobe.Howeve...
关键词：Itch-Insular cortex Prelimbic cortex Conditioned place aversion Pharmacogenetic inhibition 
环状RNA ITCH对高糖诱导的心脏成纤维细胞活化的影响与机制研究
《中华老年心脑血管病杂志》2023年第8期870-874,共5页许峥嵘 任卫东 谷君 宁改君 李小菊 赵香 史丽 胡利梅 
河北省2019年度医学科学研究课题(20190879);张家口市科学技术局2019年度市级科技计划项目(1921030D);河北省财政厅2018年政府资助专科能力建设项目(361009)。
目的 探讨环状RNA ITCH(Circ-ITCH)对高糖诱导的心脏成纤维细胞(CF)活化的影响及其机制。方法 体外培养人CF(HCF),按照处理方法的不同分为对照组、高糖组、过表达载体阴性对照(OV-NC)组、Circ-ITCH过表达载体(OV-Circ-ITCH)组;模拟物阴...
关键词：RNA 环状 循环微RNA 成纤维细胞 Smad7蛋白质 微小RNA-212-3p 
An Anterior Cingulate Cortex-to-Midbrain Projection Controls Chronic Itch in
《Neuroscience Bulletin》2023年第5期793-807,共15页Ting-Ting Zhang Su-Shan Guo Hui-Ying Wang Qi Jing Xin Yi Zi-Han Hu Xin-Ren Yu Tian-Le Xu Ming-Gang Liu Xuan Zhao 
supported by grants from the National Natural Science Foundation of China(81873787,81961128024,32170994,and 82201362);Shanghai Natural Science Foundation(18ZR1424800 and 20ZR1430000);a Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the innovative research team of high-level local universities in Shanghai.
Itch is an unpleasant sensation that provokes the desire to scratch.While acute itch serves as a protec-tive system to warn the body of external irritating agents,chronic itch is a debilitating but poorly-treated clin...
关键词：sAnterior cingulate cortex Chronic itch Ventral tegmental area-Chemogenetics Neural circuit 
葫芦素B调控circ-ITCH对鼻咽癌细胞生物学行为的影响及其机制被引量：2
《中国老年学杂志》2023年第7期1726-1730,共5页杨燕 吴玲 付海峰 
目的探讨葫芦素(Cu)B对鼻咽癌细胞增殖、迁移、侵袭的影响及其对circ-ITCH的调控作用。方法采用不同剂量(10、30、60 nmol/L)CuB处理鼻咽癌细胞5-8F(CuB-L组、CuB-M组、CuB-H组),正常培养的5-8F细胞为Con组;pcDNA、pcDNA-circ-ITCH分别...
关键词：葫芦素B circ-ITCH 鼻咽癌 增殖 迁移 侵袭 
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