云南高校图书馆联盟文献共享服务平台- PTP1B

PTP1B: 作品数：181被引量：572H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：叶菲田金英吴丽娟王树林李英俊更多>>; 相关机构：中国科学院辽宁师范大学中国医学科学院北京协和医学院吉林大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家高技术研究发展计划辽宁省自然科学基金山西省自然科学基金更多>>

Luteolin-7-diglucuronide,a novel PTP1B inhibitor,ameliorates hepatic stellate cell activation and liver fibrosis in mice: 《Acta Pharmacologica Sinica》2025年第1期122-133,共12页Bi-xi Tang Yong Zhang Dan-dan Sun Qin-yi Liu Cong Li Pei-pei Wang Li-xin Gao Xue-mei Zhang Jia Li Wei-liang Zhu Yi Zang; This article was supported by Shanghai lnstitute of Materia Medica,Chinese Academy of Sciences(No.CASIMM0120225006-2,SIMM0120232001);Shanghai Municipal Science and Technology Major Project(TM202301H002);Shanghai Committee of Science and Technology(22ZR1415200).; Liver fibrosis,one of the leading causes of morbidity and mortality worldwide,lacks effective therapy.The activation of hepatic stellate cells(HSCs)is the dominant event in hepatic fibrogenesis.Luteolin-7-diglucuronid...; 关键词：liver fibrosis PHYTOCHEMICAL luteolin 7-diglucuronide HSC activation PTP1B

Multioxidized polyketides from an endophytic Penicillium sp.YUD17006 associated with Gastrodia elata: 《Chinese Journal of Natural Medicines》2024年第11期1057-1064,共8页LI Hongtao YANG Ruining XIE Fei XIE Tianpeng TANG Linhuan ZHOU Hao DING Zhongtao; supported by the Natural Science Foundation of China(No.22267001);the Program for Innovative Research Team of Yunnan Province(No.202105AE160006);the Science and Technology Project of Yunnan Province(Nos.202201AT070225,202301AU070217);Yunnan University“Double First-Class”Construction Joint Project(No.202201BF070001-014);Basic Research Plan of Yunnan Provincial Science and Technology Department-Kunming Medical University(No.202301AY070001-186);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001);Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission&Ministry of Education,Yunnan Minzu University(No.MZY2205);he Program Innovative Research Team in Science and Technology in Kunming Medical University(No.CXTD202202)。; Three novel,highly oxygenated polyketides,multioketides A-C(1-3),and three previously described multioxidized aromatic polyketides(4-6),were isolated from an endophytic Penicillium sp.YUD17006 associated with Gastrodi...; 关键词：Penicillium sp.Multioxidized polyketides Secondary metabolite Anti-acetylcholinesterase activity PTP1B inhibit-ory activity

PTP1B抑制剂药效团模型的构建及应用: 《山东第一医科大学（山东省医学科学院）学报》2024年第9期528-532,共5页王桂玲解钏浚; 泰安市科技创新发展项目(政策引导类)(2022NS330)。; 目的构建蛋白酪氨酸磷酸酶1B(protein tyrosine phosphatase 1B,PTP1B)抑制剂的药效团筛选模型。方法通过收集文献中已报道的PTP1B小分子抑制剂,选择其中活性较强的化合物作为训练集,利用Discovery Studio中的HypoGen算法构建PTP1B抑制...; 关键词：PTP1B 药效团模型计算机辅助药物设计

The synergistic regulatory effect of PTP1B and PTK inhibitors on the development of Oedaleus decorus asiaticus Bei-Bienko: 《Journal of Integrative Agriculture》2024年第8期2752-2763,共12页Shuang Li Sibo Liu Chaomin Xu Shiqian Feng Xiongbing Tu Zehua Zhang; the National Key R&D Program of China(2022YFD1400500);the earmarked fund for China Agriculture Research System(CARS-34);the Central Public-interest Scientific Institution Basal Research Fund of China(S2022XM21)。; Tyrosine phosphorylation is crucial for controlling normal cell growth,survival,intercellular communication,gene transcription,immune responses,and other processes.protein tyrosine phosphatase(PTP)and protein tyrosine...; 关键词：PTP1B PTK INHIBITOR MAPK pathway Oedaleus decorus asiaticus development

Bioactive chemical constituents from the marine-derived fungus Cladosporium sp.DLT-5: 《Journal of Oceanology and Limnology》2024年第3期905-914,共10页Luting DAI Qingyi XIE Jiaocen GUO Qingyun MA Li YANG Jingzhe YUAN Haofu DAI Zhifang YU Youxing ZHAO; Supported by the China Agriculture Research System of MOF and MARA(CARS-21);the Financial Fund of the Ministry of Agriculture and Rural Affairs,China(No.NFZX2021);the National Natural Science Foundation of China(No.81973568)。; A new isochromanone,cladosporinisochromanone(1),accompanied by 15 known compounds(2–16)were obtained from secondary metabolites produced by marine-derived fungus Cladosporium sp.DLT-5.NMR and HRESIMS spectra elucidat...; 关键词：Cladosporium sp. marine-derived fungus neuroprotective effects protein tyrosine phosphatase 1B(PTP1B) Niemann-Pick C1 Like 1(NPC1L1) antifungal activity

Three New Hydroxytetradecenals from Amomum tsao-ko with Protein Tyrosine Phosphatase 1B and Glycogen Phosphorylase Inhibitory Activity: 《Phyton-International Journal of Experimental Botany》2024年第5期875-883,共9页Xiaolu Qin Xinyu Li Yi Yang Mei Huang Shengli Wu Pianchou Gongpan Lianzhang Wu Juncai He Changan Geng; the Yunnan Major Scientific and Technological Program(202202AE090035);Xingdian Yingcai Project(YNWR-QNBJ-2018-061);the Yunnan Fundamental Research Projects(202201AV070010,202301AS070069);Yunnan Province Science and Technology Department(202305AH340005);the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2022-KF12).; The fruits of Amomum tsao-ko(Cao-Guo)were documented in Chinese Pharmacopoeia for the treatment of abdominal pain,vomiting,and plague.In our previous study,a series of diarylheptanes and flavonoids withα-glucosidase ...; 关键词：Cao-Guo PTP1B and GPa inhibitors diabetes mellitus volatile oils

Pachymic acid exerts antitumor activities by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B: 《Asian Pacific Journal of Tropical Biomedicine》2024年第4期170-180,共11页Hao Zhang Kun Zhu Xue-Feng Zhang Yi-Hui Ding Bing Zhu Wen Meng Qing-Song Ding Fan Zhang; supported by the Zhejiang Province Traditional Chinese Medicine Health Science and Technology Program(2023ZL570).; Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying mechanism.Methods:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluor...; 关键词：Pachymic acid Lung adenocarcinoma Protein tyrosine phosphatase 1B Wnt/β-catenin signaling pathway METASTASIS ANGIOGENESIS AUTOPHAGY

基于PTP1B活性区域靶向中药成分治疗糖尿病的虚拟筛选及动力学模拟验证: 《现代药物与临床》2024年第4期848-856,共9页杨子博支爽代霖霖王慧李冬冬; 天津市科技计划项目(22JCYBJC00200);天津市卫生健康行业高层次人才项目(TJSJMYXYC-D2-034)。; 目的利用计算机辅助技术,在中药成分中针对蛋白酪氨酸磷酸酶1B(PTP1B)多个作用位点筛选抑制剂。方法整理TCMSP数据库,利用Autodock Vina和Ledock筛选,利用数据库预测中药成分类药性质、生物活性、药动学,通过动力学模拟验证结合稳定性...; 关键词：糖尿病蛋白酪氨酸磷酸酶1B 抑制剂虚拟筛选类药性质生物活性药动学 2 3 7-trihydroxy-5-(3 4-dihydroxy-E-styryl)-6 7 8 9-tetrahydro-5H-benzocycloheptene

丹蒌片通过PTP1B/PP2A/SP1途径影响甘油三酯合成改善ApoE^(-/-)AS小鼠肝脏脂质沉积的机制研究: 《时珍国医国药》2024年第3期571-575,共5页张美菱朱敬轩王杰宋囡隋国媛贾连群; 国家自然科学基金(82074145,81974548);辽宁兴辽英才计划(XLYC1902100)。; 目的探讨丹蒌片对Apo E^(-/-)AS小鼠肝脏脂质沉积及甘油三酯合成的影响及可能机制。方法将16只ApoE^(-/-)小鼠随机分为模型组、给药组各8只,8只C57BL/6J小鼠作为空白对照组。空白对照组给予基础饲料喂饲,其余小鼠给予高脂饲料喂饲,8...; 关键词：丹蒌片 ApoE^(-/-)小鼠肝脏脂质沉积甘油三酯合成

萘查耳酮类 PTP1B 抑制剂的合成与活性研究: 《井冈山大学学报（自然科学版）》2024年第1期41-47,共7页施晓文郭乔月廖远峰邓先清; 国家自然科学基金项目(21562028);吉安市2023年度指导性科技计划项目(吉市科计字(2023)6号)。; 蛋白酪氨酸磷酸酯酶1B(PTP1B)作为非受体型PTPase家族成员之一,参与很多生理和病理过程的调控,尤其是对胰岛素信号通路中能量和葡萄糖稳态的调控,使其成为治疗糖尿病和肥胖症的新靶点。本研究基于PTP1B活性位点,利用计算机辅助药物设计...; 关键词：糖尿病肥胖症萘查尔酮 PTP1B 抑制剂

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