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Inhibitory effect of ferroptosis inhibitor toxicity induced by cobalt nanoparticles through reactive oxygen species: 《中国组织工程研究》2025年第34期7310-7317,共7页Wang Chen Zhang Weinan Shen Jining Liu Fan Yuan Jishan Liu Yake; 国家自然科学基金面上项目(82172519),项目负责人:刘璠;国家自然科学基金青年科学基金项目(82002282),项目负责人:刘雅克。; BACKGROUND:Soft tissue damage induced by cobalt nanoparticles is currently the most noticeable complication in patients with artificial joint prostheses.Therefore,an effective therapeutic strategy is needed to limit t...; 关键词：cobalt nanoparticle ARTHROPLASTY ferroptosis inhibitor ferroptosis reactive oxygen species DEFERIPRONE metal implant detoxify nanobiomedicine pathway FIBROBLAST

Granulomatosis with polyangiitis induced by the anti-programmed cell death-1 inhibitor tislelizumab:A case report: 《World Journal of Clinical Cases》2025年第15期56-62,共7页Jian-Hui Zhao Jing-Jiao Wang Yi-Wen Li; BACKGROUND Immune checkpoint inhibitors(ICIs)are a new class of antitumor agents.They enhance antitumor effects by blocking inhibitory receptors and related ligands expressed on T cells.ICIs also modulate regular immu...; 关键词：Tislelizumab Programmed cell death-1 inhibitor Granulomatosis with polyangiitis Anti-neutrophil cytoplasmic antibody-associated vasculitis Case report

Prolongated and large dose of r-ATG relieves PD-L1 inhibitor-induced allograft rejection in liver transplant recipient: 《Hepatobiliary & Pancreatic Diseases International》2025年第2期221-224,共4页Yi-Jie Zhang Dian-Jie Zhou Hong Li Qi Pan Ying Cheng; To the Editor:Immune checkpoint inhibitors(ICIs)interact with critical factors involved in immunoregulation.Following the FDA approval of nivolumab as a second line therapy for unresectable hepatocellular carcinoma(HC...; 关键词：approval IMMUNE treatment

Sesamin is an effective spleen tyrosine kinase inhibitor against IgE-mediated food allergy in computational,cell-based and animal studies: 《Food Science and Human Wellness》2025年第2期469-483,共15页Yu Li Xuerui Chen Longhua Xu Xintong Tan Dapeng Li Dongxiao Sun-Waterhouse Feng Li; Incubation Program of Youth Innovation in Shandong Province;Key Research and Development Program of Shandong Province(2021TZXD007)。; Food allergy has become a global concern.Spleen tyrosine kinase(SYK)inhibitors are promising therapeutics against allergic disorders.In this study,a total of 300 natural phenolic compounds were firstly subjected to vi...; 关键词：Food allergy Spleen tyrosine kinase SESAMIN Computational tools RBL-2H3 cells BALB/c mice

Neoadjuvant therapy:Dawn of reducing the high post-surgery recurrence rate of hepatocellular carcinoma: 《World Journal of Gastrointestinal Surgery》2025年第3期57-68,共12页Xiao-Dong Zhang Lu-Yi Zhang Jia-Liang Luo Ke-Heng Yu Ke-Lei Zhu; Supported by the Zhejiang Provincial Medical and Health Science and Technology Plan,No.2022ZH050;the Health Science and Technology Project of Yinzhou District,No.2023Y03.; The high postoperative recurrence rate remains a major challenge in the treatment of hepatocellular carcinoma(HCC)following resection.Increasing research has been delved into investigating the role of neoadjuvant ther...; 关键词：Hepatocellular carcinoma Neoadjuvant therapy Locoregional therapy Molecularly targeted drug Immune checkpoint inhibitor

DNA Damage Response and Its Inhibitors:Current Perspectives and Future Directions: 《中国细胞生物学学报》2025年第3期542-559,共18页ZHENG Xueyi XIE Dan CAI Muyan; The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increas...; 关键词：DNA damage response INHIBITOR BIOMARKER

Immune checkpoint inhibitor therapy as a neoadjuvant treatment for muscle-invasive bladder carcinoma:A narrative review: 《Current Urology》2025年第1期39-42,共4页Sentai Ding Chenrui Wu Jishuang Cao Jiaju Lyu; supported by Shandong Provincial Natural Science Foundation(ZR2023LZL005);Jinan Science and Technology Development Foundation.; Immunotherapy has become a standard treatment for patients with advanced urothelial carcinoma,and neoadjuvant immunotherapy is currently being extensively explored.This reviewhighlights the initial findings and key cl...; 关键词：Muscle-invasive bladder cancer Immune checkpoint inhibitor Tislelizumab Neoadjuvant immunotherapy

Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19:A multicenter,randomized,double-blind,phase 1b trial: 《Journal of Intensive Medicine》2025年第1期70-78,共9页Norberto Chavez-Tapia Muneeba Ahsan Sayeed Shobha Luxmi Douglas J.Kasper Fenchao Xue Yang Shen Weiliang Fan Wei Yuan Bin Du; Background:Receptor-interacting protein kinase 1(RIPK1),a serine/threonine protein kinase,is mainly activated by pro-inflammatory cytokines and pathogens,including severe acute respiratory syndrome coronavirus 2(SARS-...; 关键词：COVID-19 Phase 1b trial Receptor-interacting protein 1 RIPK1 RIPK1 inhibitor SIR1-365

Inhibition mechanism of NaF on WE43 Mg alloy in NaCl solution: 《Transactions of Nonferrous Metals Society of China》2025年第2期460-473,共14页Yun-tian YANG Yu-xin ZHOU Xiao-peng LU Ji-rui MA Jun-jie YANG Fu-hui WANG; National Natural Science Foundation of China(No.52071067);Liaoning Revitalization Talents Program,China(No.XLYC2403026);Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program of China(No.RC231178);Natural Scienceof Liaoning Province,China(No.2022-YGJC-16);Fundamental Research Funds for the Central Universities,China(No.N2302019);financial supports by the National Natural Science Foundation of China(No.52101084);Guangdong Basic and Applied Basic Research Foundation,China(No.2023A1515011579);Guangzhou Basic and Applied Basic Research Foundation,China(No.2024A04J9889);National Key Research and Development Project of China(No.2023YFB3408200)。; The influence of NaF on the microstructure,composition and corrosion performance of WE43 Mg alloy in 3.5 wt.%NaCl solution was systematically investigated by means of SEM,TEM,EPMA,XRD,XPS and electrochemical measureme...; 关键词：Mg alloy CORROSION corrosion film INHIBITOR inhibition mechanism

Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway: 《World Journal of Gastroenterology》2025年第6期44-61,共18页Han-Ning Xuan Yuan Hyun Sung Kim Gye Ryeol Park Jae Eun Ryu Ji Eun Kim In Young Kang Hye Young Kim Seung Min Lee Ju Hee Oh Eileen L Yoon Dae Won Jun; Supported by the National Research Foundation of Korea Grant Funded by the Korea Government,No.RS-2024-00440477;the Korea Institute of Science and Technology Institutional Program,No.2E33111-24-042.; BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver diseases.This study aims to specifically investigate the rol...; 关键词：RAW 264.7 cell Cell death NECROPTOSIS Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease

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