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Inhibitory effect of ferroptosis inhibitor toxicity induced by cobalt nanoparticles through reactive oxygen species: 《中国组织工程研究》2025年第34期7310-7317,共7页Wang Chen Zhang Weinan Shen Jining Liu Fan Yuan Jishan Liu Yake; 国家自然科学基金面上项目(82172519),项目负责人:刘璠;国家自然科学基金青年科学基金项目(82002282),项目负责人:刘雅克。; BACKGROUND:Soft tissue damage induced by cobalt nanoparticles is currently the most noticeable complication in patients with artificial joint prostheses.Therefore,an effective therapeutic strategy is needed to limit t...; 关键词：cobalt nanoparticle ARTHROPLASTY ferroptosis inhibitor ferroptosis reactive oxygen species DEFERIPRONE metal implant detoxify nanobiomedicine pathway FIBROBLAST

A novel BCAT1 inhibitor bufalin sensitizes pancreatic cancer cells to chemotherapy: 《Genes & Diseases》2025年第3期76-79,共4页Wei Zhang Yibao Fan Milad Ashrafizadeh Dan Shi Gautam Sethi Yavuz Nuri Ertas AMAbd ElAty Xianbin Zhang Si Chen Peng Gong; supported by the National Natural Science Foundation of China(No.82405167);the Shenzhen Science and Technology Program(Guangdong,China)(No.GJHZ20220913143005010);the fundamental research project of the Shenzhen Science and Technology Innovation Commission(No.20231120113324002 and No.RCBS20231211090635056).; Pancreatic cancer is one of the most lethal cancers worldwide and is characterized by a poor prognosis.1,2 Due to its aggressive nature and lack of early symptoms,most patients are diagnosed at an advanced stage,and c...; 关键词：EPIDEMIOLOGY incidence rate pancreatic cancer resistance BUFALIN CHEMOTHERAPY novel bcat inhibitor prognosis

Treating human cancer by targeting EZH2: 《Genes & Diseases》2025年第3期205-218,共14页Mengfei Xu Chunyan Xu Rui Wang Qing Tang Qichun Zhou Wanyin Wu Xinliang Wan Handan Mo Jun Pan Sumei Wang; supported by grants from the Research Fund for Bajian Talents of Guangdong Provincial Hospital of Chinese Medicine(China)(No.BJ2022KY13);the National Natural Science Foundation of China(No.82274602);the Foundation for Basic and Applied Research of Guangdong Province,China(No.2021A1515220023,2017B030314166);the Chinese Medicine Science and Technology Research Project of Guangdong Provincial Hospital of Chinese Medicine(China)(No.YN2019QJ06);the Guangzhou Science and Technology Plan Project(Guangdong,China)(No.2024A03J0548,202201020349);the Key Project of State Key Laboratory of Dampness Syndrome of Chinese Medicine Jointly Built by Province and Ministry(China)(No.SZ2021ZZ38);Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases(China)(No.YN2023MB09);the Guangdong Traditional Chinese Medicine Project(China)(No.20231094,20241135).; Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that primarily inhibitsdownstream gene expression by tri-methylating histone H3, which is usually overexpressed intumors and participates in many processes s...; 关键词：CANCER Epigenetic modification EZH2 EZH2 inhibitor H3K27me3

Therapeutic potential of integrins in diabetic retinopathy: 《World Journal of Diabetes》2025年第5期109-118,共10页Li-Mei He Sarul Borjigin Xin-Qi Chen Zhao-Li Yan Ming-Jie Wang; Supported by the Natural Science Foundation of Inner Mongolia,No.2022MS08057;2022 Autonomous Region Medical and Health Science and Technology Plan Projects,No.202202190.; Diabetic retinopathy(DR),a leading cause of visual loss,is the result of microvascular damage induced by prolonged hyperglycemia.Numerous studies have revealed the pivotal role of integrins in the pathogenesis of DR,p...; 关键词：Diabetic retinopathy INTEGRIN INFLAMMATION Microvascular permeability Microthrombus formation ANGIOGENESIS Integrin inhibitor

Granulomatosis with polyangiitis induced by the anti-programmed cell death-1 inhibitor tislelizumab:A case report: 《World Journal of Clinical Cases》2025年第15期56-62,共7页Jian-Hui Zhao Jing-Jiao Wang Yi-Wen Li; BACKGROUND Immune checkpoint inhibitors(ICIs)are a new class of antitumor agents.They enhance antitumor effects by blocking inhibitory receptors and related ligands expressed on T cells.ICIs also modulate regular immu...; 关键词：Tislelizumab Programmed cell death-1 inhibitor Granulomatosis with polyangiitis Anti-neutrophil cytoplasmic antibody-associated vasculitis Case report

Targeting mixed lineage kinase domain-like protein's nonnecroptosis role:A new horizon in anti-inflammatory therapy for alcoholic liver disease: 《World Journal of Gastroenterology》2025年第13期158-162,共5页Yue Xi Dong Guo Shi Li Jie-Yu Guo Xing-Zhen Chen Jing-Feng Tang Ce-Fan Zhou; Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yu...; 关键词：Mixed lineage kinase domain-like protein ATP-binding pocket CPD4 inhibitor Alcoholic liver disease Therapeutic targets Liver diseases

Prolongated and large dose of r-ATG relieves PD-L1 inhibitor-induced allograft rejection in liver transplant recipient: 《Hepatobiliary & Pancreatic Diseases International》2025年第2期221-224,共4页Yi-Jie Zhang Dian-Jie Zhou Hong Li Qi Pan Ying Cheng; To the Editor:Immune checkpoint inhibitors(ICIs)interact with critical factors involved in immunoregulation.Following the FDA approval of nivolumab as a second line therapy for unresectable hepatocellular carcinoma(HC...; 关键词：approval IMMUNE treatment

Efficient UV emission from carbon dots derived from a green-tea extract: 《Nano Research》2025年第4期516-525,共10页Henry Opoku Junkai Ren Xin Zhou Peijuan Zhang Shi Tang Dongfeng Dang Ludvig Edman Jia Wang; J.C.Kempes Minnes Stipendiefond(SMK-21-0015 and SMK-1956);the Swedish Research Council(2019-02345,2020-04437,and 2021-04778);Bertil&Britt Svenssons stiftelse for belysningsteknik(2021 host-14 and 2022 host-31);the Knut and Alice Wallenberg Foundation for a Proof of Concept grant(KAW 2022.0381);the Wallenberg Initiative Materials Science for Sustainability(WISE)funded by the Knut and Alice Wallenberg Foundation(WISE-AP01-D02);the European Union through an ERC Advanced Grant(ERC,InnovaLEC,101096650).; Emissive carbon dots(CDs)that are synthesized from biomass can be highly sustainable,but the number of reported biomass-derived CDs that emit in the ultraviolet(UV)range is small.Moreover,current commercial UV-emittin...; 关键词：carbon dots ultraviolet(UV)emission biomass aggregation-induced-emission cell proliferation inhibitor

The role of glutathione peroxidase 4 in the progression,drug resistance,and targeted therapy of non-small cell lung cancer: 《Oncology Research》2025年第4期863-872,共10页JIAHENG WEI LIANGMING ZHU; Lung cancer is one of the main causes of cancer-related deaths globally,with non-small cell lung cancer(NSCLC)being the most prevalent histological subtype of lung cancer.Glutathione peroxidase 4(GPX4)is a crucial ant...; 关键词：Non-small cell lung cancer(NSCLC) Glutathione peroxidase 4(GPX4) Drug resistance INHIBITOR Biological function

Research Progress of EZH2 in Tumors and Translational Perspectives: 《Proceedings of Anticancer Research》2025年第2期43-55,共13页Yu Tian Hu-Li Li You-Fu Pan; supported by the National Natural Science Foundation of China(32360166,31760321).; Enhancer of zeste homolog 2(EZH2)is a key epigenetic regulatory protein and enzyme catalytic subunit of the polycomb repressor complex 2(PRC2),responsible for catalyzing the trimethylation of histone H3K27 and subsequ...; 关键词：EZH2 Polycomb repressor complex 2 Cell signaling INHIBITOR

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