A novel BCAT1 inhibitor bufalin sensitizes pancreatic cancer cells to chemotherapy  

作　　者：Wei Zhang Yibao Fan Milad Ashrafizadeh Dan Shi Gautam Sethi Yavuz Nuri Ertas AMAbd ElAty Xianbin Zhang Si Chen Peng Gong 

机构地区：[1]Department of General Surgery,Institute of Precision Diagnosis and Treatment of Digestive System Tumors and Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics,Carson International Cancer Center,Shenzhen University General Hospital,Shenzhen University,Shenzhen,Guangdong 518055,China [2]School of Pharmacy,Shenzhen University Medical School,Shenzhen,Guangdong 518060,China [3]Department of Pharmacology and NUS Centre for Cancer Research,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 117600,Singapore [4]Department of Biomedical Engineering,Erciyes University,Kayseri 38039,Turkey [5]Department of Technical Sciences,Western Caspian University,AZ1001,Baku,Azerbaijan Rapid Communication 3 [6]Department of Pharmacology,Faculty of Veterinary Medicine,Cairo University,Giza 12211,Egypt [7]Department of Medical Pharmacology,Medical Faculty,Ataturk University,Erzurum 25240,Turkey [8]Department of Immunology,Shenzhen University Medical School,Shenzhen,Guangdong 518060,China

出　　处：《Genes & Diseases》2025年第3期76-79,共4页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China(No.82405167);the Shenzhen Science and Technology Program(Guangdong,China)(No.GJHZ20220913143005010);the fundamental research project of the Shenzhen Science and Technology Innovation Commission(No.20231120113324002 and No.RCBS20231211090635056).

摘　　要：Pancreatic cancer is one of the most lethal cancers worldwide and is characterized by a poor prognosis.1,2 Due to its aggressive nature and lack of early symptoms,most patients are diagnosed at an advanced stage,and chemotherapy is the optimal option.3,4 Epidemiology,the incidence rate of pancreatic cancer has increased in the last two decades,from 196,000 patients in 1990 to 441,000 in 2017.Based on 2020 global cancer statistics,the annual cases of pancreatic cancer have increased to 195,773.4 Unfortunately,patients demonstrate resistance to chemotherapy,and only some of them benefit from current therapeutic strategies.

关 键 词：EPIDEMIOLOGY incidence rate pancreatic cancer resistance BUFALIN CHEMOTHERAPY novel bcat inhibitor prognosis 

分 类 号：R735.9[医药卫生—肿瘤]