BUFALIN

作品数：38被引量：138H指数：6
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相关作者：刘月平陈小义王小玲陈莉徐瑞成更多>>
相关机构：河北医科大学中国医科大学河北医科大学第四医院武警医学院更多>>
相关期刊：《World Journal of Traditional Chinese Medicine》《China Medical Abstracts(Internal Medicine)》《Journal of Chinese Pharmaceutical Sciences》《临床与实验病理学杂志》更多>>
相关基金：国家自然科学基金中国博士后科学基金辽宁省科学技术计划项目广东省自然科学基金更多>>
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A novel BCAT1 inhibitor bufalin sensitizes pancreatic cancer cells to chemotherapy
《Genes & Diseases》2025年第3期76-79,共4页Wei Zhang Yibao Fan Milad Ashrafizadeh Dan Shi Gautam Sethi Yavuz Nuri Ertas AMAbd ElAty Xianbin Zhang Si Chen Peng Gong 
supported by the National Natural Science Foundation of China(No.82405167);the Shenzhen Science and Technology Program(Guangdong,China)(No.GJHZ20220913143005010);the fundamental research project of the Shenzhen Science and Technology Innovation Commission(No.20231120113324002 and No.RCBS20231211090635056).
Pancreatic cancer is one of the most lethal cancers worldwide and is characterized by a poor prognosis.1,2 Due to its aggressive nature and lack of early symptoms,most patients are diagnosed at an advanced stage,and c...
关键词：EPIDEMIOLOGY incidence rate pancreatic cancer resistance BUFALIN CHEMOTHERAPY novel bcat inhibitor prognosis 
Author Correction:Bufalin suppresses the migration and invasion of prostate cancer cells through HOTAIR,the sponge of miR-520b
《Acta Pharmacologica Sinica》2025年第1期234-234,共1页Jian-jun Zhang Xiao-hui Zhou Yan Zhou Yong-gang Wang Bin-zhi Qian Ai-na He Zan Shen Hai-yan Hu Yang Yao 
In Fig.1c,the representative Transwell images of DU145 and PC3 cells in the bufalin group appeared incorrectly due to the mishandling in manuscript preparation.All the authors agree on the correction of our negligence...
关键词：invasion PC3 CORRECTION 
UBA3 promotes the occurrence and metastasis of intrahepatic cholangiocarcinoma through MAPK signaling pathway
《Acta Biochimica et Biophysica Sinica》2024年第2期199-209,共11页Huhu Zhang Jiahua Yang Qinghang Song Xiaoyan Ding Fulin Sun Lina Yang 
This work was supported by the grants from the National Natural Science Foundation of China(No.81803895);Shandong Province Natural Science Foundation(No.ZR2021YQ57);China Postdoctoral Science Foundation(Nos.2020M682131 and 2021T140357).
Intrahepatic cholangiocarcinoma(icC)accounts for approximately 15%of primary liver cancers,and the incidence rate has been increasing in recentyears.Surgical resection is the best treatment for IcC,but the 5-year surv...
关键词：intrahepatic cholangiocarcinoma UBA3 ANXA2 BUFALIN PROGNOSIS PROLIFERATION migration 
Prof. Pengfei Tu and Prof. Kewu Zeng have discovered the natural molecule glue bufalin
《Journal of Chinese Pharmaceutical Sciences》2022年第11期897-898,共2页无 
近日,北京大学药学院天然药物及仿生药物国家重点实验室屠鹏飞与曾克武在国际学术期刊eBioMedicine上合作发表了题为“Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer th...
关键词：蟾毒灵 国际学术期刊 北京大学药学院 鹏飞 胶水 主要活性成分 
Bufalin Induces Programmed Necroptosis in Triple-Negative Breast Cancer Drug-Resistant Cell Lines through RIP1/ROS-Mediated Pathway被引量：2
《Chinese Journal of Integrative Medicine》2022年第10期900-908,共9页LIU Xiao-dan SONG Cheng-yang KONG Cui-cui TIAN Xin 
Supported by the National Natural Science Foundation of China (No.81573654)。
Objective: To explore the effect and mechanism of action of bufalin in triple-negative breast cancer(TNBC) drug-resistant cell lines. Methods: The normal human mammary epithelial cell line, TNBC cell line, TNBC adriam...
关键词：BUFALIN NECROPTOSIS drug resistant reactive oxygen species pathway triple-negative breast cancer 
Allosteric probe-modified liposome loading bufalin-fluorouracil complex for targeted colorectal cancer therapy
《Oncology and Translational Medicine》2022年第5期239-246,共8页Fajiang Mao Xingli Wu Chenyue Yuan Haiyan Huang Yanyan Qiu Jianlin Ren Peihao Yin 
Supported by grants from the Medical Guidance Project of Shanghai Science and Technology Commission(No.19401935200);the Budget Internal Medicine Research Project of Shanghai University of Traditional Chinese Medicine(No.2020LK065).
Objective Bufalin,the main active anti-tumor monomer of toad venom,is crucial in cancer treatment.However,intrinsic issues,such as poor solubility and systematic toxicity,have considerably mitigated its anticancer fun...
关键词：BUFALIN fluorouracil colorectal cancer imaging therapy 
CD133抑制剂对人胆囊癌细胞的影响
《中华实验外科杂志》2022年第7期1284-1287,共4页郭跃 王少波 刘超 王世行 庞志刚 
目的观察Bufalin(蟾蜍灵)、AMD3100(普乐沙福)作为药物单独或联合作用于胆囊癌细胞株(GBC-SD)后,观察其对细胞增殖、迁移、凋亡以及CD133表达的影响,探讨其在胆囊癌中的作用。方法收集2017年1月至2021年12月郑州大学第二附属医院手术切...
关键词：胆囊癌 CD133 AMD3100 BUFALIN 
Bufalin suppresses ovarian cancer cell proliferation via EGFR pathway被引量：3
《Chinese Medical Journal》2022年第4期456-461,共6页Lei Dou Dan Zou Feiran Song Yuxin Jin Yin Li Yi Zhang 
This study was supported by a grant from the Special project for central guidance of local science and technology development of Liaoning province(No.2019JH6/10400006)。
Background:Previous studies have shown that bufalin exerts antitumor effects through various mechanisms.This study aimed to determine the antineoplastic mechanism of bufalin,an extract of traditional Chinese medicine ...
关键词：BUFALIN Ovarian cancer Epidermal growth factor receptor 
Near-infrared light-controllable bufalin delivery from a black phosphorus-hybrid supramolecular hydrogel for synergistic photothermal-chemo tumor therapy被引量：3
《Nano Research》2021年第11期3988-3998,共11页Jiaqi He Guoqin Chen Peng Zhao Caiwen Ou 
Financial support from the National Natural Science Foundation of China (Nos. 31771099, 81871504, and31671025);Natural Science Foundation of Guangdong Province (No. 2020A1515011066);Pearl River S&T Nova Program of Guangzhou (No. 201806010170) are greatly acknowledged. The animal procedures were performed in according to the protocol approved by the Institutional Animal Care and Use Committee at Southern Medical University.
Bufalin is efficacious in treating various tumors, however, the clinical application of which is restricted by the myocardial toxicity. Developing a smart synergetic delivery system is widely considered as a promising...
关键词：photothermal-chemo synergic therapy BUFALIN black phosphorus nanosheets supramolecular hydrogel 
Design of dual targeting immunomicelles loaded with bufalin and study of their anti-tumor effect on liver cancer被引量：2
《Journal of Integrative Medicine》2021年第5期408-417,共10页Hao Gou Ruo-chen Huang Fu-lei Zhang Yong-hua Su 
financially supported by the National Natural Science Foundation of China (81673739);the National Key Research and Development Program of China (No.2018YFC1705305);Shanghai Development Office of Traditional Chinese Medicine (No. ZY[2018-2020]-FWTX-4010);Shanghai “13th Five-year Plan” Clinical Key Department—Department of Dermatology of Traditional Chinese Medicine (No. shslczdzk05001);Clinical Research Plan of SHDC (No.SHDC2020CR3097B)。
Objective: Bufalin is an effective drug for the treatment of liver cancer. But its high toxicity, poor watersolubility, fast metabolism and short elimination half-life limit its use in tumor treatment. How to make the...
关键词：BUFALIN Liver cancer Epidermal growth factor receptor Immunomicelles 
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