ISONIAZID

作品数：64被引量：173H指数：6
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相关领域：医药卫生更多>>
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相关机构：交通大学清华大学更多>>
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相关基金：国家自然科学基金International Foundation for Science更多>>
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Ferroptosis and Intrinsic Drug-induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective
《Journal of Clinical and Translational Hepatology》2024年第12期1057-1066,共10页Hartmut Jaeschke Anup Ramachandran 
supported in part by National Institute of Diabetes and Digestive and Kidney Diseases grants R01 DK102142(HJ)and R01 DK125465(AR),as well as by National Institute of General Medical Sciencesfunded Liver Disease COBRE grants P20 GM103549(HJ)and P30 GM118247(HJ).
Drug-induced hepatotoxicity is a significant clinical issue worldwide.Given the limited treatment options for these liver injuries,understanding the mechanisms and modes of cell death is crucial for identifying novel ...
关键词：Drug hepatotoxicity ACETAMINOPHEN Lipid peroxidation Oxidative stress Ferroptosis Glutathione peroxidase 4 Erastin Ferrostatin-1 METHOTREXATE RIFAMPICIN ISONIAZID Natural products 
Characterization of isoniazid resistance and genetic mutations in isoniazid-resistant and rifampicin-susceptible Mycobacterium tuberculosis in China
《Infectious Medicine》2024年第3期23-29,共7页Dongxin Liu Bing Zhao Yang Zheng Xichao Ou Shengfen Wang Yang Zhou Yuanyuan Song Hui Xia Qiang Wei YanLin Zhao 
National Key Research and Development Project(2022YFC2305200,2022YFC2602200);Natural Science Foundation of Shenzhen(JCYJ20210324130009024)。
Background Patients with tuberculosis resistant to isoniazid but susceptible to rifampicin(Hr-Rs TB)remain a neglected demographic,despite a high disease burden and poor outcomes of these patients.The aim of this stud...
关键词：Mycobacterium tuberculosis Mono-isoniazid resistance Whole-genome sequencing Resistance mutation 
Novel Thrice-Weekly Isoniazid plus Rifapentine Short-Course Regimen for the Treatment of Latent Tuberculosis Infection in a Murine Model
《Infectious Diseases & Immunity》2024年第3期138-141,共4页Qiaoling Ruan Jingyu Zhou Shufeng Weng Lingyun Shao Wenhong Zhang 
supported by National Natural Science Foundation of China(82271794,82302533);Shanghai Municipal Science and Technology Major Project(HS2021SHZX001).
1.Introduction Tuberculosis(TB),caused by Mycobacterium tuberculosis,remains a leading cause of death among infectious diseases worldwide.Latent tuberculosis infections(LTBI)contribute to the global burden of TB disea...
关键词：REGIMEN TUBERCULOSIS TREATMENT 
Supramolecular phenolic network-engineered C-CeO_(2) nanofibers for simultaneous determination of isoniazid and hydrazine in biological fluids
《Chinese Chemical Letters》2024年第6期496-501,共6页Gang Lang Jing Feng Bo Feng Junlan Hu Zhiling Ran Zhiting Zhou Zhenju Jiang Yunxiang He Junling Guo 
supported by Cooperative Education Program of the Ministry of Education,China(Nos.202101256027 and 202102070134);National Excellent Young Scientists Found(No.00308054A1045);National Key R&D Program of China(No.2022YFA0912800);National Natural Science Foundation of China(No.22178233);Talents Program of Sichuan Province,Double First Class University Plan of Sichuan University,State Key Laboratory of Polymer Materials Engineering(No.sklpme 2020-03-01);Sichuan Tianfu Emei Project(No.2022-EC02-00073-CG)。
Electrochemical sensing provides a powerful technological means for the therapeutic drug monitoring of drug-resistant tuberculosis but requires a functionalized electrode to capture the analytes and catalyze their red...
关键词：Electrochemical detection Therapeutic drug monitoring ISONIAZID HYDRAZINE TUBERCULOSIS 
Tuberculosis in kidney transplant candidates and recipients
《World Journal of Transplantation》2024年第3期59-69,共11页Pallavi Prasad Sourabh Sharma Subashri Mohanasundaram Anupam Agarwal Himanshu Verma 
Tuberculosis(TB)is the leading cause of infectious mortality and morbidity in the world,second only to coronavirus disease 2019.Patients with chronic kidney disease and kidney transplant recipients are at a higher ris...
关键词：TUBERCULOSIS Latent Antitubercular therapy Kidney transplantation Donor Interferon-gamma release assays TUBERCULIN RIFAMPICIN ISONIAZID 
Mutation Characteristics of inhA and katG Genes in Isoniazid-Resistant Mycobacterium Tuberculosis Patients in Xinjiang
《Journal of Clinical and Nursing Research》2024年第1期140-145,共6页Shu-Tao Li Wen-Long Guan He Yang 
Xinjiang Uygur Autonomous Region Health Youth Medical Science and Technology Talents Special Project(Project number:WJW-202116)。
Objective:To analyze the mutation characteristics of inhA and katG genes in isoniazid-resistant Mycobacterium tuberculosis in Xinjiang.Methods:The katG and inhA in 148 strains of isoniazid-resistant Mycobacterium tube...
关键词：Mycobacterium tuberculosis Drug resistance ISONIAZID Gene mutation 
Completion of 6-mo isoniazid preventive treatment among eligible under six children:A cross-sectional study,Lagos,Nigeria
《World Journal of Clinical Cases》2023年第1期104-115,共12页Victor Abiola Adepoju Ademola Adelekan Aderonke Agbaje Femi Quaitey Tobi Ademola-Kay Ann Uduak Udoekpo Olusola Daniel Sokoya 
BACKGROUND Nigeria is one of the thirty high burden countries with significant contribution to the global childhood tuberculosis epidemic.Tuberculosis annual risk for children could be as high as 4%particularly in hig...
关键词：ISONIAZID CHILD TUBERCULOSIS Treatment Outcome COMPLETION Latent tuberculosis DOSAGE 
SLCO1B1, NAT2 Polymorphisms and Pharmacokinetic Variability of Rifampicin and Isoniazid in Tuberculosis Patients from Sub-Saharan Africa
《Journal of Tuberculosis Research》2022年第3期111-123,共13页Sekossounon Sanni Ablo Prudence Wachinou Corinne Simone Colette Merle Lamine Baba-Moussa Dissou Affolabi 
SLCO1B1 and NAT2 polymorphisms have been associated with the variability of Rifampicin and Isoniazid pharmacokinetic (PK). The objective of this study was to identify in African patients with tuberculosis (TB) or TB/H...
关键词：POLYMORPHISM SLCO1B1 NAT2 RIFAMPICIN ISONIAZID 
Genetic Polymorphisms and Toxicities of First-Line Antituberculosis Drugs: Systematic Review of the Literature
《Journal of Tuberculosis Research》2022年第3期124-145,共22页Sekossounon Sanni Haziz Sina Lamine Baba-Moussa 
Introduction: Polymorphisms are the main genetic factors associated with toxicities of antituberculosis drugs. This literature review summarizes the polymorphisms of the genes that code for the enzymes of the metaboli...
关键词：Polymorphism GENETICS SNP Toxicity RIFAMPICIN ISONIAZID 
A novel core-shell rifampicin/isoniazid electrospun nanofiber membrane for long time drug dissolution
《Engineered Regeneration》2022年第1期73-79,共7页Chenxi Li Yueqi Liu Ming Wei Jun Liu Xiaomin Yu Ping Hu Yong Liu 
supported by the National Natural Science Foundation of China(Grant No.21374008).
Rifampicin(RIF)and isoniazid(INH)are commonly applied jointly in clinical to improve the treatment efficacy of tuberculosis.Due to the metabolism of the kidneys,most of RIF and INH would be excreted by human bodies af...
关键词：Dual drug delivery Core-shell structure Coaxial electrospinning Phased sustained-dissolve Staphylococcus aureus 
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