ACETAMINOPHEN

作品数：166被引量：450H指数：11
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相关领域：医药卫生更多>>
相关作者：谢国红谢欣梅庞晓斌汪倩王学文更多>>
相关机构：湖首大学河南科技学院中国医药学院吉林农业大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金国家重点基础研究发展计划更多>>
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Effectiveness of oral vs intravenous acetaminophen on pain management following total joint arthroplasty: A systematic review and meta-analysis
《World Journal of Orthopedics》2025年第4期69-77,共9页Bin Lu Ai-Xian Tian Zheng-Rui Fan Xing-Wen Zhao Hong-Zhen Jin Jian-Xiong Ma Xin-Long Ma 
Supported by National Natural Science Foundation of China,No.11772226 and No.81572154.
BACKGROUND In the management of postoperative pain following total joint arthroplasty(TJA),the use of nonsteroidal anti-inflammatory drugs,including acetaminophen,plays a key role in alleviating pain.However,the compa...
关键词：Joint arthroplasty Pain management META-ANALYSIS ACETAMINOPHEN Nonsteroidal anti-inflammatory drugs 
Mogroside V protects against acetaminophen-induced liver injury by reducing reactive oxygen species and c-jun-N-terminal kinase activation in mice
《World Journal of Hepatology》2025年第3期170-179,共10页Jia-Lin Shi Tian Sun Qing Li Chun-Mei Li Jun-Fei Jin Chong Zhang 
Supported by Guangxi Natural Science Foundation of China,No.2024GXNSFAA010040;Special Fund of the Central Government Guiding Local Scientific and Technological Development by Guangxi Science and Technology Department,No.GuikeZY21195024;National Natural Science Foundation of China,No.82260499 and No.82460463.
BACKGROUND High levels of acetaminophen(APAP)consumption can result in significant liver toxicity.Mogroside V(MV)is a bioactive,plant-derived triterpenoid known for its various pharmacological activities.However,the i...
关键词：ACETAMINOPHEN Mogroside V Reactive oxygen species Liver injury C-jun-N-terminal kinase 
Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota
《Acta Pharmacologica Sinica》2025年第2期416-429,共14页Qin Yang Wen-hao He Li Xie Tao Chen Ruo-fan Liu Jia-jia Hu Jia-yin Guo Guo-zhu Tan Fu-ling Wu Peng Gu Peng Chen Yu Chen 
supported by the Guangdong Basic and Applied Basic Research Foundation(2022B1515130004);the Characteristic Innovation Project of the Guangdong Provincial Department of Education(2022KTSCX020)to YC;the Guangzhou Key Research and Development Program(2023B03J1245)to PC;the National Natural Science Foundation of China(82302092);the Guangdong Basic and Applied Basic Research Foundation(2022A1515110070)to PG;the China Postdoctoral Science Foundation(2023M741602)to QY.
Acetaminophen(APAP)overdose-induced acute liver injury(ALI)is characterized by extensive oxidative stress,and the clinical interventions for this adverse effect remain limited.Astilbin is an active compound found in t...
关键词：acute liver injury ACETAMINOPHEN ASTILBIN gut microbiota hydroxytyrosol Sirt6 
A review on reactive oxygen species-induced mechanism pathways of pharmaceutical waste degradation:Acetaminophen as a drug waste model
《Journal of Environmental Sciences》2025年第1期688-713,共26页Saba Humayun Maan Hayyan Yatimah Alias 
the Ministry of Higher Education,Research and Innovation-Oman for their support of this research through TRC block funding grant No.BFP/RGP/EBR/22/378.
Innately designed to induce physiological changes,pharmaceuticals are foreknowingly hazardous to the ecosystem.Advanced oxidation processes(AOPs)are recognized as a set of contemporary and highly efficient methods bei...
关键词：Wastewater treatment Ionic liquid Hydroxyl radical Superoxide Pharmaceutical contaminant Advanced oxidation process Deep eutectic solvent Hydrogen peroxide 
Comparison of ketorolac intravenous versus acetaminophen intravenous in treating headache following head trauma: a semi-experimental study
《Chinese Neurosurgical Journal》2024年第4期249-255,共7页Behzad Zohrevandi Marjan Hosseinnia Niloufar Balikshahi Masoud Jobaneh Ehsan Kazemnezhad Leili Naema Khodadadi-Hassankiadeh 
Background Post-traumatic headache is a disabling secondary headache disorder often attributed to traumatic brain injury and affects millions of individuals worldwide. Few studies have been done on the treatment needs...
关键词：ACETAMINOPHEN TRAUMA HEADACHE KETOROLAC 
International outbreak of acute pediatric hepatitis:Was acetaminophen the missing link?
《Pediatric Investigation》2024年第4期241-243,共3页Stephen A.Hoption Cann 
During the outbreak of acute pediatric hepatitis,two centers reported a threefold increase in cases.1 In their report,the hepatitis was preceded by an acute viral infection with a period of fasting.Patients ranged in ...
关键词：ACETAMINOPHEN acute viral infection viral infection OUTBREAK FASTING acute pediatric hepatitis 
Ferroptosis and Intrinsic Drug-induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective
《Journal of Clinical and Translational Hepatology》2024年第12期1057-1066,共10页Hartmut Jaeschke Anup Ramachandran 
supported in part by National Institute of Diabetes and Digestive and Kidney Diseases grants R01 DK102142(HJ)and R01 DK125465(AR),as well as by National Institute of General Medical Sciencesfunded Liver Disease COBRE grants P20 GM103549(HJ)and P30 GM118247(HJ).
Drug-induced hepatotoxicity is a significant clinical issue worldwide.Given the limited treatment options for these liver injuries,understanding the mechanisms and modes of cell death is crucial for identifying novel ...
关键词：Drug hepatotoxicity ACETAMINOPHEN Lipid peroxidation Oxidative stress Ferroptosis Glutathione peroxidase 4 Erastin Ferrostatin-1 METHOTREXATE RIFAMPICIN ISONIAZID Natural products 
Liver failure after Bacillus cereus food poisoning,an underrecognized entity:A case report
《World Journal of Hepatology》2024年第11期1339-1347,共9页Olivier Chatelanat Mikaël de Lorenzi-Tognon Laurent Spahr Abdessalam Cherkaoui Roger Stephan Marie Ongaro Laurent Kaiser Nicolas Goossens 
BACKGROUND Bacillus cereus(B.cereus)is known to cause 2 types of foodborne diseases;the diarrheal and emetic syndromes.They are largely underreported due to their usually self-limiting course.Rare and sometimes fatal ...
关键词：Liver failure Foodborne intoxication Bacillus cereus Toxin cereulide Emetic syndrome ACETAMINOPHEN Case report 
Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice被引量：1
《World Journal of Hepatology》2024年第10期1188-1198,共11页Chun-Mei Li Tian Sun Mou-Jie Yang Zhi Yang Qing Li Jia-Lin Shi Chong Zhang Jun-Fei Jin 
Supported by Natural Science Foundation of Guangxi,No.2020GXNSFDA238006;Special Fund of the Central Government Guiding Local Scientific and Technological Development by Guangxi Science and Technology Department,No.GuikeZY21195024;Research Enhancement Project for Junior Faculty in Higher Education Institutes of Guangxi,No.2018KY0419.
BACKGROUND Complement activation is recognized as an important factor in the progression of liver damage caused by acetaminophen(APAP).However,the role of the complement inhibitor C2-FH in APAP-induced liver injury re...
关键词：C2-FH COMPLEMENT Complement activation Acetaminophen-induced liver injury Inflammation 
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2被引量：1
《Acta Pharmacologica Sinica》2024年第8期1660-1672,共13页Fan-le Zeng Yuan Zhang Zhong-hao Wang Hui Zhang Xue-teng Meng Yi-qin Wu Zhen-zhen Qian Yu-hao Ding Jun Li Tao-tao Ma Cheng Huang 
supported by funding from National Natural Science Foundation of China(U19A2001);Anhui Fund for Distinguished Young Scholars(2022AH020050);the Scientific Research Promoti on Fund of Anhui Medical University(2022xkjT010);Scientific Reasearch Platform Improvement Project of Anhui Medical University(2023xkjT049);Research Fund of Anhui Institute of translational medicine(2021zhyx-B06,2022zhyx-B07).
Excessive acetaminophen(APAP)can induce neutrophil activation and hepatocyte death.Along with hepatocyte dysfunction and death,NETosis(a form of neutrophil-associated inflammation)plays a vital role in the progression...
关键词：acute liver injury APAP PANoptosis NETS AIM2 TLR9 
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