ASTILBIN

作品数：7被引量：6H指数：1
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相关领域：医药卫生更多>>
相关作者：蔡宇徐强燕茹费明健王俊更多>>
相关机构：南京大学中国药科大学山东第一医科大学(山东省医学科学院)更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Chemical Research in Chinese Universities》《Asian Pacific Journal of Tropical Biomedicine》更多>>
相关基金：国家自然科学基金国家杰出青年科学基金更多>>
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Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota
《Acta Pharmacologica Sinica》2025年第2期416-429,共14页Qin Yang Wen-hao He Li Xie Tao Chen Ruo-fan Liu Jia-jia Hu Jia-yin Guo Guo-zhu Tan Fu-ling Wu Peng Gu Peng Chen Yu Chen 
supported by the Guangdong Basic and Applied Basic Research Foundation(2022B1515130004);the Characteristic Innovation Project of the Guangdong Provincial Department of Education(2022KTSCX020)to YC;the Guangzhou Key Research and Development Program(2023B03J1245)to PC;the National Natural Science Foundation of China(82302092);the Guangdong Basic and Applied Basic Research Foundation(2022A1515110070)to PG;the China Postdoctoral Science Foundation(2023M741602)to QY.
Acetaminophen(APAP)overdose-induced acute liver injury(ALI)is characterized by extensive oxidative stress,and the clinical interventions for this adverse effect remain limited.Astilbin is an active compound found in t...
关键词：acute liver injury ACETAMINOPHEN ASTILBIN gut microbiota hydroxytyrosol Sirt6 
Ethyl acetate extract of Smilax glabra Roxb roots and its major active compound astilbin promote osteoblastogenesis in vitro by upregulating bone cell differentiation-associated genes
《Asian Pacific Journal of Tropical Biomedicine》2021年第12期553-560,共8页Huyen T.T.Nguyen Minh T.H.Nguyen Thu X.Nguyen Quan M.Pham Ha X.Nguyen Phuong T.M.Nguyen 
supported by the the Vietnam Academy of Science and Technology under grant NCCC 08.10/20-20;the Institute of Biotechnology under grant CS20-01。
Objective:To investigate the osteoblastogenic activity of the ethyl acetate(EtOAc)extract of Smilax glabra Roxb roots and its major active compound astilbin.Methods:Astilbin was isolated from EtOAc extract using silic...
关键词：Smilax glabra Roxb ASTILBIN CYTOTOXICITY OSTEOGENESIS OSTEOBLAST Ethyl acetate extract 
Rapid Quantification of Astilbin in Rat Plasma by Liquid Chromatography-tandem Mass Spectrometry and Its Application to Pharmacokinetic Study
《Chemical Research in Chinese Universities》2013年第6期1078-1082,共5页YIN Lei ZHANG Yun-hui ZHAO Sen CHENG Long-mei SHI Mei-yun YANG Yan SUN Yan-tong LIU Xi-dong FAWCETT J. Paul 
the National Natural Science Foundation of China，the Science and Technology Major Specialized Projects for ＂Significant New Drugs Creation＂ of the 12th Five-year Plan of China，the National Key Technology R＆D Program of the Ministry of Science and Technology,China
Astilbin is a potential immunosuppressive agent with minor cytotoxicity. Its oral bioavailability is supposed to be rather low and therefore a sensitive analytical method is required for its pharmacokinetic study afte...
关键词：ASTILBIN Liquid chromatography-tandem mass spectrometry（LC-MS/MS） PHARMACOKINETICS RAT Plasma 
Astilbin Inhibits Proliferation of Rat Aortic Smooth Muscle Cells Induced by Angiotensin Ⅱ and Down-regulates Expression of Protooncogene被引量：1
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2012年第2期181-185,共5页李平 高思海 揭伟 敖启林 黄亚非 
supported by agrant from the National Natural Science Foundation of China(No.30500656)
This study examined the effect of astilbin on the proliferation of rat aortic smooth muscle cells (RASMCs) induced by angiotensin Ⅱ (AngⅡ) and explored the possible mechanisms. Cell proliferation model of RASMCs was...
关键词：ASTILBIN vascular smooth muscle cells PROLIFERATION angiotensin Ⅱ PROTOONCOGENE NF-κB 
The Inhibitory Effect of Astilbin on the Arteriosclerosis of Murine Thoracic Aorta Transplant被引量：5
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2009年第2期212-214,共3页赵金平 李平 张韵凤 王现国 敖启林 高思海 
supported by a grant from the National Natural Sciences Foundation of China (No.30500656)
The inhibitory effect of astilbin on transplant arteriosclerosis in murine model of thoracic aorta transplantation was examined. Model of rat thoracic aorta transplantation was established. Ninety rats were divided in...
关键词：ASTILBIN aorta allografl transplant arteriosclerosis 
Effect of astilbin on inhibition of phosphatidy linositol 3-kinase-protein kinase B （PI-3K-PKB） in alloreactive T cells of mouse heart transplantation model with acute rejection
《China Medical Abstracts》2007年第2期137-137,共1页高思海 
Objective To investigate the effect of astibin on inhibition of phosphatidy linositol 3-kinase-protein kinase B（PI-3K-PKB） in alloreactive T cells of mouse heart transplantation model with acute rejection.Methods Ca...
关键词：细胞抑制 老鼠 心脏 血液循环 
中药的选择性作用与免疫性疾病的新型疗法被引量：1
《中国天然药物》2007年第5期333-337,共5页徐强 
国家自然科学基金重点项目(No30230390);国家杰出青年基金项目(No39925041);面上项目(No30472174;No20572043等)~~
免疫性疾病需要新的治疗药物,选择性免疫调控是一条新颖且可行的途径。本文通过发现并阐明一些中药及其成分的选择性免疫抑制特性,提出不同于现有免疫抑制剂的崭新作用方式和药物发现途径。
关键词：选择性免疫调控 中药 ASTILBIN T细胞 免疫性疾病 
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