Completion of 6-mo isoniazid preventive treatment among eligible under six children:A cross-sectional study,Lagos,Nigeria  

作　　者：Victor Abiola Adepoju Ademola Adelekan Aderonke Agbaje Femi Quaitey Tobi Ademola-Kay Ann Uduak Udoekpo Olusola Daniel Sokoya 

机构地区：[1]Department of HIV and Infectious Diseases,Jhpiego Nigeria,Federal Capital Territory,Abuja 900918,Nigeria [2]Department of Research,Bluegate Research Institute,Ibadan 211271,Oyo State,Nigeria [3]Clinical Services,Institute of Human Virology of Nigeria,Abuja 900918,Nigeria [4]Department of HIV and Infectious Diseases,Jhpiego Nigeria,Uyo 520108,AkwaIbom,Nigeria [5]Adolescent and Youth Care,Youth Development and Empowerment Initiative,Lagos 23401,Nigeria [6]Monitoring and Evaluation,Jhpiego Nigeria,Uyo 520108,AkwaIbom,Nigeria [7]Lagos State Tuberculosis,Buruli Ulcer and Leprosy Control Program,Ikeja 100001,Lagos,Nigeria

出　　处：《World Journal of Clinical Cases》2023年第1期104-115,共12页世界临床病例杂志

摘　　要：BACKGROUND Nigeria is one of the thirty high burden countries with significant contribution to the global childhood tuberculosis epidemic.Tuberculosis annual risk for children could be as high as 4%particularly in high tuberculosis(TB)prevalent communities.Isoniazid(INH)Preventive Therapy has been shown to prevent TB incidence but data on its implementation among children are scarce.AIM To determine the completion of INH among under six children that were exposed to adults with smear positive pulmonary TB in Lagos,Nigeria.METHODS This was a hospital-based retrospective cross-sectional review of 265 medical records of eligible children<6 years old enrolled for INH across 32 private hospitals in Lagos,Nigeria.The study took place between July and September 2020.Data was collected on independent variables(age,gender,type of facility,TB screening,dose and weight)and outcome variables(INH outcome and proportion lost to follow up across months 1-6 of INH treatment).RESULTS About 53.8%of the participants were female,95.4%were screened for TB and none was diagnosed of having TB.The participants’age ranged from 1 to 72 mo with a mean of 36.01±19.67 mo,and 40.2%were between the ages of 1-24 mo.Only 155(59.2%)of the 262 participants initiated on INH completed the six-month treatment.Cumulatively,107(41.0%)children were lost to follow-up at the end of the sixth month.Of the cumulative 107 loss to follow-up while on INH,largest drop-offs were reported at the end of month 2,52(49%)followed by 20(19%),17(16%),11(10.2%)and 7(6.5%)at months 3,4,5 and 6 respectively.The analysis showed that there was no significant association between age,gender,type of facility and completion of INH treatment(P>0.005).CONCLUSION This study demonstrated suboptimal INH completion rate among children with only 6 out of 10 children initiated on INH who completed a 6-mo treatment in Lagos,Nigeria.The huge drop-offs in the first 2 mo of INH calls for innovative strategies such as the use of 60-d INH calendar that would facilitate reminder and early

关 键 词：ISONIAZID CHILD TUBERCULOSIS Treatment Outcome COMPLETION Latent tuberculosis DOSAGE 

分 类 号：R72[医药卫生—儿科]