Supramolecular phenolic network-engineered C-CeO_(2) nanofibers for simultaneous determination of isoniazid and hydrazine in biological fluids  

作　　者：Gang Lang Jing Feng Bo Feng Junlan Hu Zhiling Ran Zhiting Zhou Zhenju Jiang Yunxiang He Junling Guo 

机构地区：[1]School of Science,Xihua University,Chengdu 610039,China [2]BMI Center for Biomass Materials and Nanointerfaces,College of Biomass Science and Engineering,Sichuan University,Chengdu 610065,China [3]Southwest Computer Co.,Ltd.,Chongqing 400060,China [4]Bioproducts Institute,Department of Chemical and Biological Engineering,The University of British Columbia,Vancouver V6T 1Z4,Canada [5]State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China [6]National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan University,Chengdu 610065,China

出　　处：《Chinese Chemical Letters》2024年第6期496-501,共6页中国化学快报（英文版）

基　　金：supported by Cooperative Education Program of the Ministry of Education,China(Nos.202101256027 and 202102070134);National Excellent Young Scientists Found(No.00308054A1045);National Key R&D Program of China(No.2022YFA0912800);National Natural Science Foundation of China(No.22178233);Talents Program of Sichuan Province,Double First Class University Plan of Sichuan University,State Key Laboratory of Polymer Materials Engineering(No.sklpme 2020-03-01);Sichuan Tianfu Emei Project(No.2022-EC02-00073-CG)。

摘　　要：Electrochemical sensing provides a powerful technological means for the therapeutic drug monitoring of drug-resistant tuberculosis but requires a functionalized electrode to capture the analytes and catalyze their redox reactions.Herein,we construct a nickel-tannic acid supramolecular network(Ni-TA)on the surface of electrospun-derived C-CeO_(2) nanofiber for the sensitive and simultaneous detection of isoniazid(INZ)and hydrazine(HYD).Mechanistic investigations demonstrate that Ni-TA is electronegative and hydrophilic,thus facilitating an efficient mass and electron transfer.Ni-TA/C-CeO_(2) has higher adsorption rate constants(0.091 g mg^(-1)h^(-1)for INZ,and 0.062 g mg^(-1)h^(-1)for HYD)than native C-CeO_(2)(0.075 g mg^(-1)h^(-1)for INZ,and 0.047 g mg^(-1)h^(-1)for HYD).Moreover,Ni-TA/C-CeO_(2)(56Ω)has lower charge transfer resistances than C-CeO_(2)(417Ω).Ni-TA/C-CeO_(2) performs low detection limits and wide linearity ranges for INZ(0.012μmol/L and 0.1-400μmol/L,respectively)and HYD(0.008μmol/L and 0.015-1420μmol/L,respectively),coupled with high selectivity,cycle stability and reproducibility.This research demonstrated the promising applications of Ni-TA/C-CeO_(2) by analyzing human-collected plasma and urine samples.

关 键 词：Electrochemical detection Therapeutic drug monitoring ISONIAZID HYDRAZINE TUBERCULOSIS 

分 类 号：O657.1[理学—分析化学] R96[理学—化学]