Toosendanin:upgrade of an old agent in cancer treatment  

作　　者：LI Shuwei XIONG Qingyi SHEN Yiwen LIN Jiayi ZHANG Lijun WU Ye JIN Jinmei LUAN Xin 

机构地区：[1]Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《Chinese Journal of Natural Medicines》2024年第10期887-899,共13页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82322073,82304790,and 82173846);China Postdoctoral Innovative Talent Support Program(BX20220213);Shanghai Rising-Star Program(No.22QA1409100);Oriental Scholars of Shanghai(No.TP2022081);Jiangxi Province Thousand Talents Program(No.jxsq2023102168);Young Talent Lifting Project of China Association of Chinese Medicine[No.CACM-(2021-QNRC2-A08)];Shanghai Science and Technology Innovation Action Plan(No.21S11902800);Three-year Action Plan for Shanghai TCM Development and Inheritance Program[Nos.ZY(2021-2023)-0401 and ZY(2021-2023)-0208];Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004);CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009);Shanghai Sailing Program(Nos.22YF1445000 and 23YF1442600);the National Key R&D Program of China(No.2022YFC3502000);High-level Key Discipline of National Administration of Traditional Chinese Medicine,Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology,Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(No.2023YZZ02)。

摘　　要：Toosendanin(TSN),a tetracyclic triterpenoid derived from Melia toosendan and M.azedarach,demonstrates broad application prospects in cancer treatment.Although previously employed as a pesticide,recent studies have revealed its potential therapeutic value in treating various types of cancer.TSN exerts an anticancer effect via mechanisms including proliferation inhibition,apoptosis induction,migration suppression,and angiogenesis inhibition.However,TSN's toxicity,particularly its hepatotoxicity,significantly limits its therapeutic application.This review explored the dual nature of TSN,evaluating both its anticancer potential and toxicological risks,emphasizing the importance of balancing these aspects in therapeutic applications.Furthermore,we investigated the incorporation of TSN into novel therapeutic strategies,such as Proteolysis-targeting chimeras(PROTAC)technology and nanotechnology-based drug delivery systems(DDS),which enhance treatment efficacy while mitigating toxicity in normal tissues.

关 键 词：TOOSENDANIN Cancer therapy HEPATOTOXICITY PROTAC Nano-delivery systems 

分 类 号：R965[医药卫生—药理学]